Myocardial Recovery and the Failing Heart: Medical, Device and Mechanical Methods

Background: Cardiac remodeling describes the molecular, cellular, and interstitial changes that cause the ventricle to develop pathologic geometry as heart failure progresses. Reverse remodeling, or the healing of a failing heart, leads to improved mortality and quality of life. Findings: Therapies that lead to reverse remodeling include medications such as β-blockers and angiotensin-converting enzyme inhibitors; cardiac resynchronization therapy with biventricular pacing; and mechanical support with left ventricular assist devices. Conclusions: Further study is needed to better predict which patients will benefit most from these therapies and will then go on to experience reverse remodeling and myocardial recovery

The fundamental parameters of the roAp star 10 Aql

Due to the strong magnetic field and related abnormal surface layers existing in rapidly oscillating Ap stars, systematic errors are likely to be present when determining their effective temperatures, which potentially compromises asteroseismic studies of these pulsators. Using long-baseline interferometry, our goal is to determine accurate angular diameters of a number of roAp targets to provide a temperature calibration for these stars. We obtained interferometric observations of 10 Aql with the visible spectrograph VEGA at the CHARA array. We determined a limb-darkened angular diameter of 0.275+/-0.009 mas and deduced a linear radius of 2.32+/-0.09 R_sun. We estimated the star's bolometric flux and used it, in combination with its parallax and angular diameter, to determine the star's luminosity and effective temperature. For two data sets of bolometric flux we derived an effective temperature of 7800+/-170 K and a luminosity of 18+/-1 L_sun or of 8000+/-210 K and 19+/-2 L_sun. We used these fundamental parameters together with the large frequency separation to constrain the mass and the age of 10 Aql, using the CESAM stellar evolution code. Assuming a solar chemical composition and ignoring all kinds of diffusion and settling of elements, we obtained a mass of 1.92 M_sun and an age of 780 Gy or a mass of 1.95 M_sun and an age of 740 Gy, depending on the considered bolometric flux. For the first time, we managed to determine an accurate angular diameter for a star smaller than 0.3 mas and to derive its fundamental parameters. In particular, by only combining our interferometric data and the bolometric flux, we derived an effective temperature that can be compared to those derived from atmosphere models. Such fundamental parameters can help for testing the mechanism responsible for the excitation of the oscillations observed in the magnetic pulsating stars

Fundamental Properties of Cool Stars with Interferometry

We present measurements of fundamental astrophysical properties of nearby, low-mass, K- and M-dwarfs from our DISCOS survey (DIameterS of COol Stars). The principal goal of our study is the determination of linear radii and effective temperatures for these stars. We calculate their radii from angular diameter measurements using the CHARA Array and Hipparcos distances. Combined with bolometric flux measurements based on literature photometry, we use our angular diameter results to calculate their effective surface temperatures. We present preliminary results established on an assortment of empirical relations to the stellar effective temperature and radius that are based upon these measurements. We elaborate on the discrepancy seen between theoretical and observed stellar radii, previously claimed to be related to stellar activity and/or metallicity. Our preliminary conclusion, however, is that convection plays a larger role in the determination of radii of these late-type stars. Understanding the source of the radius disagreement is likely to impact other areas of study for low-mass stars, such as the detection and characterization of extrasolar planets in the habitable zones.Comment: Contribution to Proceedings of Cool Stars 16 Workshop; 8 pages in ASP format; 9 figure

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets.

G protein-coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus formation. Here we provide the first evidence that GPCR kinase 6 (GRK6) serves this role in platelets, using GRK6-/- mice generated by CRISPR-Cas9 genome editing to examine the consequences of GRK6 knockout on GPCR-dependent signaling. Hemostatic thrombi formed in GRK6-/- mice are larger than in wild-type (WT) controls during the early stages of thrombus formation, with a rapid increase in platelet accumulation at the site of injury. GRK6-/- platelets have increased platelet activation, but in an agonist-selective manner. Responses to PAR4 agonist or adenosine 5\u27-diphosphate stimulation in GRK6-/- platelets are increased compared with WT littermates, whereas the response to thromboxane A2 (TxA2) is normal. Underlying these changes in GRK6-/- platelets is an increase in Ca2+ mobilization, Akt activation, and granule secretion. Furthermore, deletion of GRK6 in human MEG-01 cells causes an increase in Ca2+ response and PAR1 surface expression in response to thrombin. Finally, we show that human platelet activation in response to thrombin causes an increase in binding of GRK6 to PAR1, as well as an increase in the phosphorylation of PAR1. Deletion of GRK6 in MEG-01 cells causes a decrease in PAR1 phosphorylation. Taken together, these data show that GRK6 regulates the hemostatic response to injury through PAR- and P2Y12-mediated effects, helping to limit the rate of platelet activation during thrombus growth and prevent inappropriate platelet activation

The Ages of A-Stars I: Interferometric Observations and Age Estimates for Stars in the Ursa Major Moving Group

We have observed and spatially resolved a set of seven A-type stars in the nearby Ursa Major moving group with the Classic, CLIMB, and PAVO beam combiners on the CHARA Array. At least four of these stars have large rotational velocities ($v \sin i$ $\gtrsim$ 170 $\mathrm{km~s^{-1}}$) and are expected to be oblate. These interferometric measurements, the stars' observed photometric energy distributions, and $v \sin i$ values are used to computationally construct model oblate stars from which stellar properties (inclination, rotational velocity, and the radius and effective temperature as a function of latitude, etc.) are determined. The results are compared with MESA stellar evolution models (Paxton et al. 2011, 2013) to determine masses and ages. The value of this new technique is that it enables the estimation of the fundamental properties of rapidly rotating stars without the need to fully image the star. It can thus be applied to stars with sizes comparable to the interferometric resolution limit as opposed to those that are several times larger than the limit. Under the assumption of coevality, the spread in ages can be used as a test of both the prescription presented here and the MESA evolutionary code for rapidly rotating stars. With our validated technique, we combine these age estimates and determine the age of the moving group to be 414 $\pm$ 23 Myr, which is consistent with, but much more precise than previous estimates.Comment: Accepted by Ap

Interferometry of ϵ\epsilon Aurigae: Characterization of the asymmetric eclipsing disk

We report on a total of 106 nights of optical interferometric observations of the $\epsilon$ Aurigae system taken during the last 14 years by four beam combiners at three different interferometric facilities. This long sequence of data provides an ideal assessment of the system prior to, during, and after the recent 2009-2011 eclipse. We have reconstructed model-independent images from the 10 in-eclipse epochs which show that a disk-like object is indeed responsible for the eclipse. Using new 3D, time-dependent modeling software, we derive the properties of the F-star (diameter, limb darkening), determine previously unknown orbital elements ($\Omega$, $i$), and access the global structures of the optically thick portion of the eclipsing disk using both geometric models and approximations of astrophysically relevant density distributions. These models may be useful in future hydrodynamical modeling of the system. Lastly, we address several outstanding research questions including mid-eclipse brightening, possible shrinking of the F-type primary, and any warps or sub-features within the disk.Comment: 105 pages, 57 figures. This is an author-created, un-copyedited version of an article accepted for publication in Astrophysical Journal Supplement Series. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from i

The CHARA Array Angular Diameter of HR 8799 Favors Planetary Masses for Its Imaged Companions

HR 8799 is an hF0 mA5 gamma Doradus, lambda Bootis, Vega-type star best known for hosting four directly imaged candidate planetary companions. Using the CHARA Array interferometer, we measure HR 8799's limb-darkened angular diameter to be 0.342 +/- 0.008 mas; this is the smallest interferometrically measured stellar diameter to date, with an error of only 2%. By combining our measurement with the star's parallax and photometry from the literature, we greatly improve upon previous estimates of its fundamental parameters, including stellar radius (1.44 +/- 0.06 R_Sun), effective temperature (7193 +/- 87 K, consistent with F0), luminosity (5.05 +/- 0.29 L_Sun), and the extent of the habitable zone (1.62 AU to 3.32 AU). These improved stellar properties permit much more precise comparisons with stellar evolutionary models, from which a mass and age can be determined, once the metallicity of the star is known. Considering the observational properties of other lambda Bootis stars and the indirect evidence for youth of HR 8799, we argue that the internal abundance, and what we refer to as the effective abundance, is most likely near-solar. Finally, using the Yonsei-Yale evolutionary models with uniformly scaled solar-like abundances, we estimate HR 8799's mass and age considering two possibilities: 1.516 +0.038/-0.024 M_Sun and 33 +7/-13 Myr if the star is contracting toward the zero age main-sequence or 1.513 +0.023/-0.024 M_Sun and 90 +381/-50 Myr if it is expanding from it. This improved estimate of HR 8799's age with realistic uncertainties provides the best constraints to date on the masses of its orbiting companions, and strongly suggests they are indeed planets. They nevertheless all appear to orbit well outside the habitable zone of this young star.Comment: Accepted for publication in ApJ; 37 pages, 6 tables, 13 figure

The fundamental parameters of the roAp star γ\gamma Equulei

Physical processes working in the stellar interiors as well as the evolution of stars depend on some fundamental stellar properties, such as mass, radius, luminosity, and chemical abundances. A classical way to test stellar interior models is to compare the predicted and observed location of a star on theoretical evolutionary tracks in a H-R diagram. This requires the best possible determinations of stellar mass, radius, luminosity and abundances. To derive its fundamental parameters, we observed the well-known rapidly oscillating Ap star, $\gamma$ Equ, using the visible spectro-interferometer VEGA installed on the optical CHARA array. We computed the calibrated squared visibility and derived the limb-darkened diameter. We used the whole energy flux distribution, the parallax and this angular diameter to determine the luminosity and the effective temperature of the star. We obtained a limb-darkened angular diameter of 0.564~$\pm$~0.017~mas and deduced a radius of $R$~=~2.20~$\pm$~0.12~${\rm R_{\odot}}$. Without considering the multiple nature of the system, we derived a bolometric flux of $(3.12\pm 0.21)\times 10^{-7}$ erg~cm$^{-2}$~s$^{-1}$ and an effective temperature of 7364~$\pm$~235~K, which is below the effective temperature that has been previously determined. Under the same conditions we found a luminosity of $L$~=~12.8~$\pm$~1.4~${\rm L_{\odot}}$. When the contribution of the closest companion to the bolometric flux is considered, we found that the effective temperature and luminosity of the primary star can be, respectively, up to $\sim$~100~K and up to $\sim$~0.8~L$_\odot$ smaller than the values mentioned above.These new values of the radius and effective temperature should bring further constraints on the asteroseismic modelling of the star.Comment: Accepted by A&

Stellar Diameters and Temperatures. I. Main-Sequence A, F, and G Stars

We have executed a survey of nearby, main-sequence A-, F-, and G-type stars with the CHARA Array, successfully measuring the angular diameters of forty-four stars with an average precision of ~1.5%. We present new measures of the bolometric flux, which in turn leads to an empirical determination of the effective temperature for the stars observed. In addition, these CHARA-determined temperatures, radii, and luminosities are fit to Yonsei-Yale model isochrones to constrain the masses and ages of the stars. These results are compared to indirect estimates of these quantities obtained by collecting photometry of the stars and applying them to model atmospheres and evolutionary isochrones. We find that for most cases, the models overestimate the effective temperature by ~1.5%-4% when compared to our directly measured values. The overestimated temperatures and underestimated radii in these works appear to cause an additional offset in the star's surface gravity measurements, which consequently yield higher masses and younger ages, in particular for stars with masses greater than ~1.3 M_☉. Additionally, we compare our measurements to a large sample of eclipsing binary stars, and excellent agreement is seen within both data sets. Finally, we present temperature relations with respect to (B – V) and (V – K) colors as well as spectral type, showing that calibration of effective temperatures with errors ~1% is now possible from interferometric angular diameters of stars