Data management study, volume 5. Appendix J - Contractor data package procurement and contracting /PC/ Final report

Contractor data package for administration of procurement and contracting of Voyager spacecraft system

Disruption of Bradycardia During Vigilance: Autonomic Cardiac Dysregulation is Prelude to Disinhibition, Hyperarousal, and Attention Bias in Combat Veterans with PTSD

We propose a model to account for the post‐traumatic stress disorder (PTSD) symptoms of disinhibition, hyperarousal, and attention bias. We review the background literature which is the foundation on which our model rests, present key results of our ongoing research, and suggest testable hypotheses for further research. Our laboratory is in a Veterans Affairs (VA) Medical Center, where we began our work with a search for the significant causes and predictors of hyperarousal in combat veterans with PTSD using eyeblink and autonomic conditioning protocols. We believe our studies will lead to integration of a treatment intervention for war veterans (and equally as well for treatment of the traumatically stressed in the general population). Our research has begun to show strong associations between lowered heart rate variability (HRV) and PTSD. Loss of bradycardia during normal vigilance is the cause of lowered HRV, which impairs appraisal of threat value of environmental stimulation, thereby leading to disinhibition, hyperarousal, and attention bias toward and away from threat. The next steps of research we plan are outlined and designed to elucidate how HRV biofeedback is a promising intervention to increase HRV during vigilance of stimuli and restore cognitive appraisal and response selection, thereby reducing PTSD symptoms and normalizing behavior

Layered XY-Models, Anyon Superconductors, and Spin-Liquids

The partition function of the double-layer $XY$ model in the (dual) Villain form is computed exactly in the limit of weak coupling between layers. Both layers are found to be locked together through the Berezinskii-Kosterlitz-Thouless transition, while they become decoupled well inside the normal phase. These results are recovered in the general case of a finite number of such layers. When re-interpreted in terms of the dual problems of lattice anyon superconductivity and of spin-liquids, they also indicate that the essential nature of the transition into the normal state found in two dimensions persists in the case of a finite number of weakly coupled layers.Comment: 10 pgs, TeX, LA-UR-94-394

Blocking neutrophil integrin activation prevents ischemia-reperfusion injury.

Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders. Talin induces allosteric rearrangements in integrins that increase affinity for ligands (activation). Talin also links integrins to actin and other proteins that enable formation of adhesions. Structural studies have identified a talin1 mutant (L325R) that perturbs activation without impairing talin's capacity to link integrins to actin and other proteins. Here, we found that mice engineered to express only talin1(L325R) in myeloid cells were protected from renal ischemia-reperfusion injury. Dissection of neutrophil function in vitro and in vivo revealed that talin1(L325R) neutrophils had markedly impaired chemokine-induced, β2 integrin-mediated arrest, spreading, and migration. Surprisingly, talin1(L325R) neutrophils exhibited normal selectin-induced, β2 integrin-mediated slow rolling, in sharp contrast to the defective slow rolling of neutrophils lacking talin1 or expressing a talin1 mutant (W359A) that blocks talin interaction with integrins. These studies reveal the importance of talin-mediated activation of integrins for renal ischemia-reperfusion injury. They further show that neutrophil arrest requires talin recruitment to and activation of integrins. However, although neutrophil slow rolling requires talin recruitment to integrins, talin-mediated integrin activation is dispensable

Collaboration and teamwork: immersion and presence in an online learning environment

In the world of OTIS, an online Internet School for occupational therapists, students from four European countries were encouraged to work collaboratively through problem-based learning by interacting with each other in a virtual semi-immersive environment. This paper describes, often in their own words, the experience of European occupational therapy students working together across national and cultural boundaries. Collaboration and teamwork were facilitated exclusively through an online environment, since the students never met each other physically during the OTIS pilot course. The aim of the paper is to explore the observations that here was little interaction between students from different tutorial groups and virtual teamwork developed in each of the cross-cultural tutorial groups. Synchronous data from the students was captured during tutorial sessions and peer-booked meetings and analysed using the qualitative constructs of ‘immersion’, ‘presence’ and ‘reflection in learning’. The findings indicate that ‘immersion’ was experienced only to a certain extent. However, both ‘presence’ and shared presence were found by the students, within their tutorial groups, to help collaboration and teamwork. Other evidence suggests that communities of interest were established. Further study is proposed to support group work in an online learning environment. It is possible to conclude that collaborative systems can be designed, which encourage students to build trust and teamwork in a cross cultural online learning environment.</p

Tick‐, mosquito‐, and rodent‐borne parasite sampling designs for the National Ecological Observatory Network

Parasites and pathogens are increasingly recognized as significant drivers of ecological and evolutionary change in natural ecosystems. Concurrently, transmission of infectious agents among human, livestock, and wildlife populations represents a growing threat to veterinary and human health. In light of these trends and the scarcity of long‐term time series data on infection rates among vectors and reservoirs, the National Ecological Observatory Network (NEON) will collect measurements and samples of a suite of tick‐, mosquito‐, and rodent‐borne parasites through a continental‐scale surveillance program. Here, we describe the sampling designs for these efforts, highlighting sampling priorities, field and analytical methods, and the data as well as archived samples to be made available to the research community. Insights generated by this sampling will advance current understanding of and ability to predict changes in infection and disease dynamics in novel, interdisciplinary, and collaborative ways

The Anomalous Hall Effect in YBa2_2Cu3_3O7_7

The temperature dependence of the normal state Hall effect and magnetoresistance in YBa$_2$Cu$_3$O$_7$ is investigated using the Nearly Antiferromagnetic Fermi Liquid description of planar quasiparticles. We find that highly anisotropic scattering at different regions of the Fermi surface gives rise to the measured anomalous temperature dependence of the resistivity and Hall coefficient while yielding the universal temperature dependence of the Hall angle observed for both clean and dirty samples. This universality is shown to arise from the limited momentum transfers available for the anomalous, spin fluctuation scattering and is preserved for any system with strong antiferromagnetic correlations.Comment: REVTeX, 10 pages + 4 figures in a single (compressed/uuencoded) PostScript fil

Updating DL-Lite ontologies through first-order queries

In this paper we study instance-level update in DL-LiteA, the description logic underlying the OWL 2 QL standard. In particular we focus on formula-based approaches to ABox insertion and deletion. We show that DL-LiteA, which is well-known for enjoying first-order rewritability of query answering, enjoys a first-order rewritability property also for updates. That is, every update can be reformulated into a set of insertion and deletion instructions computable through a nonrecursive datalog program. Such a program is readily translatable into a first-order query over the ABox considered as a database, and hence into SQL. By exploiting this result, we implement an update component for DLLiteA-based systems and perform some experiments showing that the approach works in practice.Peer ReviewedPostprint (author's final draft

A Self-Organized Method for Computing the Epidemic Threshold in Computer Networks

In many cases, tainted information in a computer network can spread in a way similar to an epidemics in the human world. On the other had, information processing paths are often redundant, so a single infection occurrence can be easily "reabsorbed". Randomly checking the information with a central server is equivalent to lowering the infection probability but with a certain cost (for instance processing time), so it is important to quickly evaluate the epidemic threshold for each node. We present a method for getting such information without resorting to repeated simulations. As for human epidemics, the local information about the infection level (risk perception) can be an important factor, and we show that our method can be applied to this case, too. Finally, when the process to be monitored is more complex and includes "disruptive interference", one has to use actual simulations, which however can be carried out "in parallel" for many possible infection probabilities

Highly Variable Acquisition Rates of \u3ci\u3eIxodes scapularis\u3c/i\u3e (Acari: Ixodidae) by Birds on an Atlantic Barrier Island

Acquisition of ticks by bird hosts is a central process in the transmission cycles of many tick-borne zoonoses, but tick recruitment by birds has received little direct study. We documented acquisition of Ixodes scapularis Say on birds at Fire Island, NY, by removing ticks from mist-netted birds, and recording the number of ticks on birds recaptured within 4 d of release. Eight bird species acquired at least 0.8 ticks bird−1 day−1 during the seasonal peak for at least one age class of I. scapularis. Gray Catbirds, Eastern Towhees, Common Yellowthroats, and Northern Waterthrushes collectively accounted for 83% of all tick acquisitions; and six individuals apportioned among Black-billed Cuckoo, Gray Catbird, Eastern Towhee, and Common Yellowthroat were simultaneously infested with both larvae and nymphs. Bird species with the highest acquisition rates were generally ground foragers, whereas birds that did not acquire ticks in our samples generally foraged above the ground. Tick acquisition by birds did not differ between deciduous and coniferous forests. Among the 15 bird species with the highest recruitment rates, acquisition of nymphs was not correlated with acquisition of larvae. Tick acquisition rates by individual bird species were not correlated with the reservoir competence of those species for Lyme borreliae. However, birds with high tick acquisition rates can contribute large numbers of infected ticks, and thus help maintain the enzootic cycle, even if their levels of reservoir competence are relatively low