New trajectory-driven aerosol and chemical process model Chemical and Aerosol Lagrangian Model (CALM)

A new Chemical and Aerosol Lagrangian Model (CALM) has been developed and tested. The model incorporates all central aerosol dynamical processes, from nucleation, condensation, coagulation and deposition to cloud formation and in-cloud processing. The model is tested and evaluated against observations performed at the SMEAR II station located at Hyytiälä (61° 51' N, 24° 17' E) over a time period of two years, 2000–2001. The model shows good agreement with measurements throughout most of the year, but fails in reproducing the aerosol properties during the winter season, resulting in poor agreement between model and measurements especially during December–January. Nevertheless, through the rest of the year both trends and magnitude of modal concentrations show good agreement with observation, as do the monthly average size distribution properties. The model is also shown to capture individual nucleation events to a certain degree. This indicates that nucleation largely is controlled by the availability of nucleating material (as prescribed by the [H<sub>2</sub>SO<sub>4</sub>]), availability of condensing material (in this model 15% of primary reactions of monoterpenes (MT) are assumed to produce low volatile species) and the properties of the size distribution (more specifically, the condensation sink). This is further demonstrated by the fact that the model captures the annual trend in nuclei mode concentration. The model is also used, alongside sensitivity tests, to examine which processes dominate the aerosol size distribution physical properties. It is shown, in agreement with previous studies, that nucleation governs the number concentration during transport from clean areas. It is also shown that primary number emissions almost exclusively govern the CN concentration when air from Central Europe is advected north over Scandinavia. We also show that biogenic emissions have a large influence on the amount of potential CCN observed over the boreal region, as shown by the agreement between observations and modeled results for the receptor SMEAR II, Hyytiälä, during the studied period

The Planck Surveyor mission: astrophysical prospects

Although the Planck Surveyor mission is optimized to map the cosmic microwave background anisotropies, it will also provide extremely valuable information on astrophysical phenomena. We review our present understanding of Galactic and extragalactic foregrounds relevant to the mission and discuss on one side, Planck's impact on the study of their properties and, on the other side, to what extent foreground contamination may affect Planck's ability to accurately determine cosmological parameters. Planck's multifrequency surveys will be unique in their coverage of large areas of the sky (actually, of the full sky); this will extend by two or more orders of magnitude the flux density interval over which mm/sub-mm counts of extragalactic sources can be determined by instruments already available (like SCUBA) or planned for the next decade (like the LSA-MMA or the space mission FIRST), which go much deeper but over very limited areas. Planck will thus provide essential complementary information on the epoch-dependent luminosity functions. Bright radio sources will be studied over a poorly explored frequency range where spectral signatures, essential to understand the physical processes that are going on, show up. The Sunyaev-Zeldovich effect, with its extremely rich information content, will be observed in the direction of a large number of rich clusters of Galaxies. Thanks again to its all sky coverage, Planck will provide unique information on the structure and on the emission properties of the interstellar medium in the Galaxy. At the same time, the foregrounds are unlikely to substantially limit Planck's ability to measure the cosmological signals. Even measurements of polarization of the primordial Cosmic Microwave background fluctuations appear to be feasible.Comment: 20 pages, Latex (use aipproc2.sty, aipproc2.cls, epsfig.sty), 10 PostScript figures; invited review talk, Proc. of the Conference: "3 K Cosmology", Roma, Italy, 5-10 October 1998, AIP Conference Proc, in press Note: Figures 6 and 7 have been replaced by new and correct version

Simultaneous Planck, Swift, and Fermi observations of X-ray and gamma-ray selected blazars

We present simultaneous Planck, Swift, Fermi, and ground-based data for 105 blazars belonging to three samples with flux limits in the soft X-ray, hard X-ray, and gamma-ray bands, with additional 5GHz flux-density limits to ensure a good probability of a Planck detection. We compare our results to those of a companion paper presenting simultaneous Planck and multi-frequency observations of 104 radio-loud northern active galactic nuclei selected at radio frequencies. While we confirm several previous results, our unique data set allows us to demonstrate that the selection method strongly influences the results, producing biases that cannot be ignored. Almost all the BL Lac objects have been detected by the Fermi Large Area Telescope (LAT), whereas 30% to 40% of the flat-spectrum radio quasars (FSRQs) in the radio, soft X-ray, and hard X-ray selected samples are still below the gamma-ray detection limit even after integrating 27 months of Fermi-LAT data. The radio to sub-millimetre spectral slope of blazars is quite flat, with similar to 0 up to about 70GHz, above which it steepens to similar to -0.65. The BL Lacs have significantly flatter spectra than FSRQs at higher frequencies. The distribution of the rest-frame synchrotron peak frequency (nu(S)(peak)) in the spectral energy distribution (SED) of FSRQs is the same in all the blazar samples with = 10(13.1+.1) Hz, while the mean inverse Compton peak frequency, , ranges from 10(21) to 10(22) Hz. The distributions of nu(S)(peak) and nu(S)(peak) of BL Lacs are much broader and are shifted to higher energies than those of FSRQs; their shapes strongly depend on the selection method. The Compton dominance of blazars, defined as the ratio of the inverse Compton to synchrotron peak luminosities, ranges from less than 0.2 to nearly 100, with only FSRQs reaching values larger than about 3. Its distribution is broad and depends strongly on the selection method, with gamma-ray selected blazars peaking at similar to 7 or more, and radio-selected blazars at values close to 1, thus implying that the common assumption that the blazar power budget is largely dominated by high-energy emission is a selection effect. A comparison of our multi-frequency data with theoretical predictions shows that simple homogeneous SSC models cannot explain the simultaneous SEDs of most of the gamma-ray detected blazars in all samples. The SED of the blazars that were not detected by Fermi-LAT may instead be consistent with SSC emission. Our data challenge the correlation between bolometric luminosity and nu(S)(peak) predicted by the blazar sequence. --author-supplied descriptio

Radio Wavelength Constraints on the Sources of the Far Infrared Background

The cosmic far infrared background detected recently by the COBE-DIRBE team is presumably due, in large part, to the far infrared (FIR) emission from all galaxies. We take the well-established correlation between FIR and radio luminosity for individual galaxies and apply it to the FIR background. We find that these sources make up about half of the extragalactic radio background, the other half being due to AGN. This is in agreement with other radio observations, which leads us to conclude that the FIR-radio correlation holds well for the very faint sources making up the FIR background, and that the FIR background is indeed due to star-formation activity (not AGN or other possible sources). If these star-forming galaxies have a radio spectral index between 0.4 and 0.8, and make up 40 to 60% of the extragalactic radio background, we find that they have redshifts between roughly 1 and 2, in agreement with recent estimates by Madau et al. of the redshift of peak star-formation activity. We compare the observed extragalactic radio background to the integral over the logN-logS curve for star-forming radio sources, and find that the slope of the curve must change significantly below about 1 microjansky. At 1 microjansky, the faint radio source counts predict about 25 sources per square arcminute, and these will cause SIRTF to be confusion limited at 160micron.Comment: 10 pages including 1 figure, AASTeX, accepted by Ap

Effects of augmented exercise therapy time after stroke: a meta-analysis

<p><b>Background and Purpose:</b> To present a systematic review of studies that addresses the effects of intensity of augmented exercise therapy time (AETT) on activities of daily living (ADL), walking, and dexterity in patients with stroke.</p> <p><b>Summary of Review:</b> A database of articles published from 1966 to November 2003 was compiled from MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, PEDro, DARE, and PiCarta using combinations of the following key words: stroke, cerebrovascular disorders, physical therapy, physiotherapy, occupational therapy, exercise therapy, rehabilitation, intensity, dose–response relationship, effectiveness, and randomized controlled trial. References presented in relevant publications were examined as well as abstracts in proceedings. Studies that satisfied the following selection criteria were included: (1) patients had a diagnosis of stroke; (2) effects of intensity of exercise training were investigated; and (3) design of the study was a randomized controlled trial (RCT). For each outcome measure, the estimated effect size (ES) and the summary effect size (SES) expressed in standard deviation units (SDU) were calculated for ADL, walking speed, and dexterity using fixed and random effect models. Correlation coefficients were calculated between observed individual effect sizes on ADL of each study, additional time spent on exercise training, and methodological quality. Cumulative meta-analyses (random effects model) adjusted for the difference in treatment intensity in each study was used for the trials evaluating the effects of AETT provided. Twenty of the 31 candidate studies, involving 2686 stroke patients, were included in the synthesis. The methodological quality ranged from 2 to 10 out of the maximum score of 14 points. The meta-analysis resulted in a small but statistically significant SES with regard to ADL measured at the end of the intervention phase. Further analysis showed a significant homogeneous SES for 17 studies that investigated effects of increased exercise intensity within the first 6 months after stroke. No significant SES was observed for the 3 studies conducted in the chronic phase. Cumulative meta-analysis strongly suggests that at least a 16-hour difference in treatment time between experimental and control groups provided in the first 6 months after stroke is needed to obtain significant differences in ADL. A significant SES supporting a higher intensity was also observed for instrumental ADL and walking speed, whereas no significant SES was found for dexterity.</p> <p><b>Conclusion:</b> The results of the present research synthesis support the hypothesis that augmented exercise therapy has a small but favorable effect on ADL, particularly if therapy input is augmented at least 16 hours within the first 6 months after stroke. This meta-analysis also suggests that clinically relevant treatment effects may be achieved on instrumental ADL and gait speed.</p&gt

Violation of the Cauchy-Schwarz inequality with matter waves

The Cauchy-Schwarz (CS) inequality -- one of the most widely used and important inequalities in mathematics -- can be formulated as an upper bound to the strength of correlations between classically fluctuating quantities. Quantum mechanical correlations can, however, exceed classical bounds.Here we realize four-wave mixing of atomic matter waves using colliding Bose-Einstein condensates, and demonstrate the violation of a multimode CS inequality for atom number correlations in opposite zones of the collision halo. The correlated atoms have large spatial separations and therefore open new opportunities for extending fundamental quantum-nonlocality tests to ensembles of massive particles.Comment: Final published version (with minor changes). 5 pages, 3 figures, plus Supplementary Materia

Characterization of Dicer-deficient murine embryonic stem cells

Dicer is an RNase III-family nuclease that initiates RNA interference (RNAi) and related phenomena by generation of the small RNAs that determine the specificity of these gene silencing pathways. We have previously shown that Dicer is essential for mammalian development, with Dicer-deficient mice dying at embryonic day 7.5 with a lack of detectable multipotent stem cells. To permit a more detailed investigation of the biological roles of Dicer, we have generated embryonic stem cell lines in which their single Dicer gene can be conditionally inactivated. As expected, Dicer loss compromises maturation of microRNAs and leads to a defect in gene silencing triggered by long dsRNAs. However, the absence of Dicer does not affect the ability of small interfering RNAs to repress gene expression. Of interest, Dicer loss does compromise the proliferation of ES cells, possibly rationalizing the phenotype previously observed in Dicer-null animals. Dicer loss also affects the abundance of transcripts from mammalian centromeres but does so without a pronounced affect on histone modification status at pericentric repeats or methylation of centromeric DNA. These studies provide a conditional model of RNAi deficiency in mammals that will permit the dissection of the biological roles of the RNAi machinery in cultured mammalian cells

Three-dimensional correlated-fermion phase separation from analysis of the geometric mean of the individual susceptibilities

A quasi-Gaussian approximation scheme is formulated to study the strongly correlated imbalanced fermions thermodynamics, where the mean-field theory is not applicable. The non-Gaussian correlation effects are understood to be captured by the statistical geometric mean of the individual susceptibilities. In the three-dimensional unitary fermions ground state, an {\em universal} non-linear scaling transformation relates the physical chemical potentials with the individual Fermi kinetic energies. For the partial polarization phase separation to full polarization, the calculated critical polarization ratio is $P_C={[1-(1-\xi)^{6/5}]}/{[1+(1-\xi)^{6/5}]}\doteq 0.34$. The $\xi=4/9$ defines the ratio of the symmetric ground state energy density to that of the ideal fermion gas.Comment: Minor changes with typos correcte