675 research outputs found
Bangladesh's Approach towards International Criminal Law: A Case Study of International Crimes Tribunal Bangladesh
The International Crimes Tribunal Bangladesh that has been found by the Bangladeshi Government to try war crimes during India Pakistan war of 1971. The tribunal is violating the fair trial rights as guaranteed by Constitution, the International Covenant on Civil and Political Rights and International Humanitarian Law and the standard of the International Crimes Tribunal Bangladesh is far below than that setup by The International Criminal Tribunal for the former Yugoslavia, the International Criminal Tribunal for Rwanda and the International Criminal Court. These irregularities imply serious concern over the proceedings of the said tribunal. Study seeks to describe the International Law about war crimes particularly with respect to fair trial provisions and it compare the proceedings of the Bangladeshi tribunal with the other internationally recognized tribunals
Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells
In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line. The chimeric protein combines the versatility in 24-meric assembly and cargo incorporation capability of Archaeglobus fulgidus ferritin with specific binding of human H ferritin to CD71, the “heavy duty” carrier responsible for transferrin-iron uptake. Delivery of ferritin-encapsulated cytochrome C to the Acute Promyelocytic Leukemia (APL) NB4 cell line, highly resistant to transfection by conventional methods, was successfully achieved in vitro. The effective liberation of cytochrome C within the cytosolic environment, demonstrated by double fluorescent labelling, induced apoptosis in the cancer cells
A coherent triggered search for single spin compact binary coalescences in gravitational wave data
In this paper we present a method for conducting a coherent search for single
spin compact binary coalescences in gravitational wave data and compare this
search to the existing coincidence method for single spin searches. We propose
a method to characterize the regions of the parameter space where the single
spin search, both coincident and coherent, will increase detection efficiency
over the existing non-precessing search. We also show example results of the
coherent search on a stretch of data from LIGO's fourth science run but note
that a set of signal based vetoes will be needed before this search can be run
to try to make detections.Comment: 14 pages, 4 figure
Classical dynamics and stability of collapsing thick shells of matter
We study the collapse towards the gravitational radius of a macroscopic
spherical thick shell surrounding an inner massive core. This overall
electrically neutral macroshell is composed by many nested delta-like massive
microshells which can bear non-zero electric charge, and a possibly non-zero
cosmological constant is also included. The dynamics of the shells is described
by means of Israel's (Lanczos) junction conditions for singular hypersurfaces
and, adopting a Hartree (mean field) approach, an effective Hamiltonian for the
motion of each microshell is derived which allows to check the stability of the
matter composing the macroshell. We end by briefly commenting on the quantum
effects which may arise from the extension of our classical treatment to the
semiclassical level.Comment: 16 pages in IOP style, 8 figures, accepted for publication in Class.
Quantum Gra
Fabrication and characterization of thin piezoelectric β-poly(vinylidene fluoride) films
The polymer polyvinylidene fluoride (PVDF) has four phases, each characterized by different molecular configurations of the polymer chains. In its beta phase it arranges in an all-trans configuration with dipolar symmetry, exhibiting piezoelectric effects. During the production of thin PVDF films by spin-coating, the polymer chains are not aligned and the dipoles are not oriented. To achieve the desired piezoelectric behavior, it is necessary to optimize both the chain alignment and the dipole orientation processes. We here present an easy procedure to maximize the percentage of the beta phase in the polymer production. The efficiency and reliability of such method has been assessed through Fourier-Transform Infra-Red and Raman spectroscopies, while the morphological differences of the two phases have been analyzed through Scanning Electron Microscopy. The results confirm the efficiency of this method
Reticulon1-C modulates protein disulphide isomerase function
Endoplasmic reticulum (ER) is the primary site for the synthesis and folding of secreted and membrane-bound proteins. Accumulation of unfolded and misfolded proteins in ER underlies a wide range of human neurodegenerative disorders. Hence, molecules regulating the ER stress response represent potential candidates as drug targets for tackling these diseases. Protein disulphide isomerase (PDI) is a chaperone involved in ER stress pathway, its activity being an important cellular defense against protein misfolding. Here, we demonstrate that human neuroblastoma SH-SY5Y cells overexpressing the reticulon protein 1-C (RTN1-C) reticulon family member show a PDI punctuate subcellular distribution identified as ER vesicles. This represents an event associated with a significant increase of PDI enzymatic activity. We provide evidence that the modulation of PDI localization and activity does not only rely upon ER stress induction or upregulation of its synthesis, but tightly correlates to an alteration in its nitrosylation status. By using different RTN1-C mutants, we demonstrate that the observed effects depend on RTN1-C N-terminal region and on the integrity of the microtubule network. Overall, our results indicate that RTN1-C induces PDI redistribution in ER vesicles, and concomitantly modulates its activity by decreasing the levels of its S-nitrosylated form. Thus RTN1-C represents a promising candidate to modulate PDI function
Evaluation of the imaging performance of the TECNOMUSE muon tomograph and its feasibility in a real scenario
Muon tomography is a very promising imaging technique for the control of cargo
containers. It takes advantage of cosmic muons and their interaction mechanisms to reconstruct
images of the volume traversed by these particles. In the present work, the imaging
performance of a novelmuon tomography scanner based on resistive plate chambers detectors
is investigated. By means of several Monte Carlo simulations, some imaging parameters are
evaluated. The results in terms of spatial resolution, field-of-view and volume and material
recognition make the presented scanner and its geometry suitable for muon tomograph
Exploring the Levinthal limit in protein folding
According to the thermodynamic hypothesis, the native state of proteins is uniquely defined by their amino acid sequence. On the other hand, according to Levinthal, the native state is just a local minimum of the free energy and a given amino acid sequence, in the same thermodynamic conditions, can assume many, very different structures that are as thermodynamically stable as the native state. This is the Levinthal limit explored in this work. Using computer simulations, we compare the interactions that stabilize the native state of four different proteins with those that stabilize three non-native states of each protein and find that the nature of the interactions is very similar for all such 16 conformers. Furthermore, an enhancement of the degree of fluctuation of the non-native conformers can be explained by an insufficient relaxation to their local free energy minimum. These results favor Levinthal's hypothesis that protein folding is a kinetic non-equilibrium process.FCT - Foundation for Science and Technology, Portugal [UID/Multi/04326/2013]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho Nacional de Desenvolvimento Cientia co e Tecnologico (CNPq
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