A search in the COS-B data base for correlated time variability in regions containing objects of interest

As is well known, association of the gamma-ray sources with celestial objects is, in general, difficult on a pure positional basis, while correlated time variability could obviously provide such proof. This technique can be employed on regions of the gamma-ray sky containing interesting objects of known variability at some wavelength even in the absence of a recognized gamma-ray excess with the aim to extract a weak but predictable signal from the surrounding noise. This technique is applied here on a longer variability time scale, generally of the order of days. Photons coming from the sky regions centered on the various celestial objects considered were selected with energies 100 MeV and with arrival directions within an energy-dependent area of radius of approx 6 deg at 100 MeV. In order to construct a time profile of such photons, their arrival times were grouped in bins of dimensions defined by the available photons number and by the value of the period searched for

Floquet interface states in illuminated three-dimensional topological insulators

Recent experiments showed that the surface of a three dimensional topological insulator develops gaps in the Floquet-Bloch band spectrum when illuminated with a circularly polarized laser. These Floquet-Bloch bands are characterized by non-trivial Chern numbers which only depend on the helicity of the polarization of the radiation field. Here we propose a setup consisting of a pair of counter-rotating lasers, and show that one-dimensional chiral states emerge at the interface between the two lasers. These interface states turn out to be spin-polarized and may trigger interesting applications in the field of optoelectronics and spintronics.Comment: 5 pages with 3 figures + supplemental materia

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia

Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent this clinical problem. Here we analyzed the activity of the BH3 mimetic ABT-737 in ALL, exploring the synergistic effects with the mTOR inhibitor CCI-779 on ABT-737 resistant cells. We showed that a low Mcl-1/Bcl-2 plus Bcl-xL protein ratio determined ABT-737 responsiveness. ABT-737 exposure further decreased Mcl-1, inducing apoptosis on sensitive models and primary samples, while not affecting resistant cells. Co-inhibition of Bcl-2 and the mTOR pathway resulted cytotoxic on ABT-737 resistant models, by downregulating mTORC1 activity and Mcl-1 in a proteasome-independent manner. Although Mcl-1 seemed to be critical, ectopic modulation did not correlate with apoptosis changes. Importantly, dual targeting proved effective on ABT-737 resistant samples, showing additive/synergistic effects. Together, our results show the efficacy of BH3 mimetics as single agent in the majority of the ALL samples and demonstrate that resistance to ABT-737 mostly correlated with Mcl-1 overexpression. Co-targeting of the Bcl-2 protein family and mTOR pathway enhanced drug-induced cytotoxicity by suppressing Mcl-1, providing a novel therapeutic approach to overcome BH3 mimetics resistance in ALL

Multiterminal conductance of a floquet topological insulator

We report on simulations of the dc conductance and quantum Hall response of a Floquet topological insulator using Floquet scattering theory. Our results reveal that laser-induced edge states lead to quantum Hall plateaus once imperfect matching with the nonilluminated leads is lessened. The magnitude of the Hall plateaus, however, is not directly related to the number and chirality of all the edge states at a given energy, as usual. Instead, the plateaus are dominated by those edge states adding to the time-averaged density of states. Therefore, the dc quantum Hall conductance of a Floquet topological insulator is not directly linked to topological invariants of the full Floquet bands.publishedVersionFil: Foa Torres, Luis Eduardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina.Fil: Foa Torres, Luis Eduardo Francisco. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Pérez Piskunow, Pablo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina.Fil: Pérez Piskunow, Pablo Matías. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Balseiro, Carlos A. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina.Fil: Balseiro, Carlos A. Comisión Nacional de Energía Atómica. Instituto Balseiro; Argentina.Fil: Balseiro, Carlos A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Usaj, Gonzalo. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina.Fil: Usaj, Gonzalo. Comisión Nacional de Energía Atómica. Instituto Balseiro; Argentina.Fil: Usaj, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Física de los Materiales Condensado

Towards a time-reversal mirror for quantum systems

The reversion of the time evolution of a quantum state can be achieved by changing the sign of the Hamiltonian as in the polarization echo experiment in NMR. In this work we describe an alternative mechanism inspired by the acoustic time reversal mirror. By solving the inverse time problem in a discrete space we develop a new procedure, the perfect inverse filter. It achieves the exact time reversion in a given region by reinjecting a prescribed wave function at its periphery.Comment: 6 pages, 4 figures. Introduction modified, references added, one figure added to improve the discussio

A randomised controlled trial of cognitive behavioural treatment for obsessive compulsive disorder in children and adolescents

Cognitive behaviour therapy (CBT) for young people with obsessive compulsive disorder (OCD) has become the treatment of first choice. However, the literature is largely based on studies emphasising exposure and response prevention. In this study, we report on a randomised controlled trial of CBT for young people carried out in typical outpatient clinic conditions which focused on cognitions. A randomised controlled trial compares 10 sessions of manualised cognitive behavioural treatment with a 12-week waiting list for adolescents and children with OCD. Assessors were blind to treatment allocation. 21 consecutive patients with OCD aged between 9 and 18 years were recruited. The group who received treatment improved more than a comparison group who waited for 3 months. The second group was treated subsequently using the same protocol and made similar gains. In conclusion, CBT can be delivered effectively to young people with OCD in typical outpatient settings

Single-parameter spin-pumping in driven metallic rings with spin-orbit coupling

We consider the generation of a pure spin-current at zero bias voltage with a single time-dependent potential. To such end we study a device made of a mesoscopic ring connected to electrodes and clarify the interplay between a magnetic flux, spin-orbit coupling, and non-adiabatic driving in the production of a spin and electrical current. By using Floquet theory, we show that the generated spin to charge current ratio can be controlled by tuning the spin-orbit coupling.publishedVersionFil: Ramos Andrade, Juan Pablo. Universidad Católica del Norte. Departamento de Física; Chile.Fil: Foa Torres, Luis Eduardo Francisco. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Foa Torres, Luis Eduardo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina.Fil: Orellana, P. A. Universidad Técnica Federico Santa María. Departamento de Física; Chile.Fil: Apel, Víctor Marcelo. Universidad Católica del Norte. Departamento de Física; Chile.Física de los Materiales Condensado

The Bosnian version of the international self-report measure of posttraumatic stress disorder, the Posttraumatic Stress Diagnostic Scale, is reliable and valid in a variety of different adult samples affected by war

BACKGROUND: The aim of the present study was to assess the internal consistency and discriminant and convergent validity of the Bosnian version of a self-report measure of posttraumatic stress disorder (PTSD), the Posttraumatic Stress Diagnostic Scale (PTDS). The PTDS yields both a PTSD diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders 4(th )edition (DSM-IV) and a measure of symptom severity. METHODS: 812 people living in Sarajevo or in Banja Luka in Bosnia-Herzegovina, of whom the majority had experienced a high number of traumatic war events, were administered the PTDS and other measures of trauma-related psychopathology. The psychometric properties of the instrument were assessed using Cronbach's alpha and principal components analysis, and its construct validity was assessed via Spearman correlation coefficients with the other instruments. RESULTS: The PTDS and its subscales demonstrated high internal consistency. The principal components revealed by an exploratory analysis are broadly consistent with the DSM-IV subscales except that they reproduce some previously reported difficulties with the "numbing" items from the avoidance subscale. The construct validity of the PTDS was supported by appropriate correlations with other relevant measures of trauma related psychopathology. CONCLUSION: The Bosnian version of the PTDS thus appears to be a time-economic and psychometrically sound measure for screening and assessing current PTSD. This self-report measure awaits further validation by interview methods