Analytic studies of local-severe-storm observables by satellites

Attention is concentrated on the exceptionally violet whirlwind, often characterized by a fairly vertical axis of rotation. For a cylindrical polar coordinate system with axis coincident with the axis of rotation, the secondary flow involves the radial and axial velocity components. The thesis advanced is, first, that a violent whirlwind is characterized by swirl speeds relative to the axis of rotation on the order of 90 m/s, with 100 m/s being close to an upper bound. This estimate is based on interpretation of funnel-cloud shape (which also suggests properties of the radial profile of swirl, as well as the maximum magnitude); an error assessment of the funnel-cloud interpretation procedure is developed. Second, computation of ground-level pressure deficits achievable from typical tornado-spawning ambients by idealized thermohydrostatic processes suggests that a two-cell structure is required to sustain such large speeds

Study of Unmanned Systems to Evaluate the Martian Environment. Volume II - Experiments

Unmanned space mission to determine Martian environmental factors influencing design of systems for manned space mission to Mars - mission experiment requirement

Study of Unmanned Systems to Evaluate the Martian Environment. Volume IV - Summary

Unmanned space mission to determine Martian environmental factors influencing design of systems for manned space mission to Mars - summary repor

Analytic studies on satellite detection of severe, two-cell tornadoes

It is argued that a two-cell structure is likely to be the unique property, and potentially satellite-accessible observable, of the exceptionally severe tornado. Analysis elucidating the dynamic, thermodynamic, and geometric properties of this two-cell structure is described. The analysis ultimately will furnish instrumentation requirements

Study of Unmanned Systems to Evaluate the Martian Environment. Volume I - Sensitivity Analysis

Unmanned space mission to determine Martian environmental factors influencing design of systems for manned space mission to Mars - mission sensitivity analysi

Analytical Approximations for the Collapse of an Empty Spherical Bubble

The Rayleigh equation 3/2 R'+RR"+p/rho=0 with initial conditions R(0)=Rmax, R'(0)=0 models the collapse of an empty spherical bubble of radius R(T) in an ideal, infinite liquid with far-field pressure p and density rho. The solution for r=R/Rmax as a function of time t=T/Tcollapse, where R(Tcollapse)=0, is independent of Rmax, p, and rho. While no closed-form expression for r(t) is known we find that s(t)=(1-t^2)^(2/5) approximates r(t) with an error below 1%. A systematic development in orders of t^2 further yields the 0.001%-approximation r*(t)=s(t)[1-a Li(2.21,t^2)], where a=-0.01832099 is a constant and Li is the polylogarithm. The usefulness of these approximations is demonstrated by comparison to high-precision cavitation data obtained in microgravity.Comment: 5 pages, 2 figure

Wind Field and Trajectory Models for Tornado-Propelled Objects

A mathematical model to predict the trajectory of tornado born objects postulated to be in the vicinity of nuclear power plants is developed. An improved tornado wind field model satisfied the no slip ground boundary condition of fluid mechanics and includes the functional dependence of eddy viscosity with altitude. Subscale wind tunnel data are obtained for all of the missiles currently specified for nuclear plant design. Confirmatory full-scale data are obtained for a 12 inch pipe and automobile. The original six degree of freedom trajectory model is modified to include the improved wind field and increased capability as to body shapes and inertial characteristics that can be handled. The improved trajectory model is used to calculate maximum credible speeds, which for all of the heavy missiles are considerably less than those currently specified for design. Equivalent coefficients for use in three degree of freedom models are developed and the sensitivity of range and speed to various trajectory parameters for the 12 inch diameter pipe are examined

NF-κB perturbation reveals unique immunomodulatory functions in Prx1 + Fibroblasts that Promote Development of Atopic Dermatitis

Skin is composed of diverse cell populations that cooperatively maintain homeostasis. Up-regulation of the nuclear factor кB (NF-кB) pathway may lead to the development of chronic inflammatory disorders of the skin, but its role during the early events remains unclear. Through analysis of single-cell RNA sequencing data via iterative random forest leave one out prediction, an explainable artificial intelligence method, we identified an immunoregulatory role for a unique paired related homeobox-1 (Prx1)+ fibroblast subpopulation. Disruption of Ikkb-NF-кB under homeostatic conditions in these fibroblasts paradoxically induced skin inflammation due to the overexpression of C-C motif chemokine ligand 11 (CCL11; or eotaxin-1) characterized by eosinophil infiltration and a subsequent TH2 immune response. Because the inflammatory phenotype resembled that seen in human atopic dermatitis (AD), we examined human AD skin samples and found that human AD fibroblasts also overexpressed CCL11 and that perturbation of Ikkb-NF-кB in primary human dermal fibroblasts up-regulated CCL11. Monoclonal antibody treatment against CCL11 was effective in reducing the eosinophilia and TH2 inflammation in a mouse model. Together, the murine model and human AD specimens point to dysregulated Prx1+ fibroblasts as a previously unrecognized etiologic factor that may contribute to the pathogenesis of AD and suggest that targeting CCL11 may be a way to treat AD-like skin lesions. © 2022 The Authors, some rights reserve