1,379 research outputs found
A simple dependence between protein evolution rate and the number of protein-protein interactions
BACKGROUND: It has been shown for an evolutionarily distant genomic comparison that the number of protein-protein interactions a protein has correlates negatively with their rates of evolution. However, the generality of this observation has recently been challenged. Here we examine the problem using protein-protein interaction data from the yeast Saccharomyces cerevisiae and genome sequences from two other yeast species. RESULTS: In contrast to a previous study that used an incomplete set of protein-protein interactions, we observed a highly significant correlation between number of interactions and evolutionary distance to either Candida albicans or Schizosaccharomyces pombe. This study differs from the previous one in that it includes all known protein interactions from S. cerevisiae, and a larger set of protein evolutionary rates. In both evolutionary comparisons, a simple monotonic relationship was found across the entire range of the number of protein-protein interactions. In agreement with our earlier findings, this relationship cannot be explained by the fact that proteins with many interactions tend to be important to yeast. The generality of these correlations in other kingdoms of life unfortunately cannot be addressed at this time, due to the incompleteness of protein-protein interaction data from organisms other than S. cerevisiae. CONCLUSIONS: Protein-protein interactions tend to slow the rate at which proteins evolve. This may be due to structural constraints that must be met to maintain interactions, but more work is needed to definitively establish the mechanism(s) behind the correlations we have observed
C-axis Optical Sum Rule in Josephson Coupled Vortex State
Observed violations of the -axis optical sum rule can give important
information on deviations from in-plane Fermi liquid behavior and on the nature
of interlayer coupling between adjacent copper oxide planes. Application of a
magnetic field perpendicular to these planes is another way to probe in-plane
dynamics. We find that the optical sum rule is considerably modified in the
presence of the -axis magnetic field. Interlayer correlation of pancake
vortices is involved in the sum rule modification; however, details of the
vortex distribution in the plane are less important.Comment: one figure. To be published in PRB (Sep. 20001
Spin-Wave Theory of the Spiral Phase of the t-J Model
A graded H.P,realization of the SU(2|1) algebra is proposed.A spin-wave
theory with a condition that the sublattice magnetization is zero is
discussed.The long-range spiral phase is investigated.The spin-spin correlator
is calculated.Comment: 17 page
Continuous symmetry of C60 fullerene and its derivatives
Conventionally, the Ih symmetry of fullerene C60 is accepted which is
supported by numerous calculations. However, this conclusion results from the
consideration of the molecule electron system, of its odd electrons in
particular, in a close-shell approximation without taking the electron spin
into account. Passing to the open-shell approximation has lead to both the
energy and the symmetry lowering up to Ci. Seemingly contradicting to a
high-symmetry pattern of experimental recording, particularly concerning the
molecule electronic spectra, the finding is considered in the current paper
from the continuous symmetry viewpoint. Exploiting both continuous symmetry
measure and continuous symmetry content, was shown that formal Ci symmetry of
the molecule is by 99.99% Ih. A similar continuous symmetry analysis of the
fullerene monoderivatives gives a reasonable explanation of a large variety of
their optical spectra patterns within the framework of the same C1 formal
symmetry exhibiting a strong stability of the C60 skeleton.Comment: 11 pages. 5 figures. 6 table
Charge pairing, superconducting transition and supersymmetry in high-temperature cuprate superconductors
We propose a model for high-T superconductors, valid for
, that includes both the spin fluctuations of the
Cu magnetic ions and of the O doped holes. Spin-charge separation
is taken into account with the charge of the doped holes being associated to
quantum skyrmion excitations (holons) of the Cu spin background. The
holon effective interaction potential is evaluated as a function of doping,
indicating that Cooper pair formation is determined by the competition between
the spin fluctuations of the Cu background and of spins of the O
doped holes (spinons). The superconducting transition occurs when the spinon
fluctuations dominate, thereby reversing the sign of the interaction. At this
point (), the theory is supersymmetric at short distances
and, as a consequence, the leading order results are not modified by radiative
corrections. The critical doping parameter for the onset of superconductivity
at T=0 is obtained and found to be a universal constant determined by the shape
of the Fermi surface. Our theoretical values for are in good
agreement with the experiment for both LSCO and YBCO.Comment: RevTex, 4 pages, no figure
High Temperature Superconductivity: the explanation
Soon after the discovery of the first high temperature superconductor by
Georg Bednorz and Alex Mueller in 1986 the late Sir Nevill Mott answering his
own question "Is there an explanation?" [Nature v 327 (1987) 185] expressed a
view that the Bose-Einstein condensation (BEC) of small bipolarons, predicted
by us in 1981, could be the one. Several authors then contemplated BEC of real
space tightly bound pairs, but with a purely electronic mechanism of pairing
rather than with the electron-phonon interaction (EPI). However, a number of
other researchers criticized the bipolaron (or any real-space pairing) scenario
as incompatible with some angle-resolved photoemission spectra (ARPES), with
experimentally determined effective masses of carriers and unconventional
symmetry of the superconducting order parameter in cuprates. Since then the
controversial issue of whether the electron-phonon interaction (EPI) is crucial
for high-temperature superconductivity or weak and inessential has been one of
the most challenging problems of contemporary condensed matter physics. Here I
outline some developments in the bipolaron theory suggesting that the true
origin of high-temperature superconductivity is found in a proper combination
of strong electron-electron correlations with a significant finite-range
(Froehlich) EPI, and that the theory is fully compatible with the key
experiments.Comment: 8 pages, 2 figures, invited comment to Physica Script
Curved Koszul duality theory
38 pagesInternational audienceWe extend the bar-cobar adjunction to operads and properads, not necessarily augmented. Due to the default of augmentation, the objects of the dual category are endowed with a curvature. We handle the lack of augmentation by extending the category of coproperads to include objects endowed with a curvature. As usual, the bar-cobar construction gives a (large) cofibrant resolution for any properad, such as the properad encoding unital and counital Frobenius algebras, a notion which appears in 2d-TQFT. We also define a curved Koszul duality theory for operads or properads presented with quadratic, linear and constant relations, which provides the possibility for smaller relations. We apply this new theory to study the homotopy theory and the cohomology theory of unital associative algebras
Resistin-Like Molecule-β Inhibits SGLT-1 Activity and Enhances GLUT2-Dependent Jejunal Glucose Transport
International audienceOBJECTIVE: An increased expression of RELM-beta (resistin-like molecule-beta), a gut-derived hormone, is observed in animal models of insulin resistance/obesity and intestinal inflammation. Intestinal sugar absorption is modulated by dietary environment and hormones/cytokines. The aim of this study was to investigate the effect of RELM-beta on intestinal glucose absorption. RESEARCH DESIGN AND METHODS: Oral glucose tolerance test was performed in mice and rats in the presence and the absence of RELM-beta. The RELM-beta action on glucose transport in rat jejunal sacs, everted rings, and mucosal strips was explored as well as downstream kinases modulating SGLT-1 and GLUT2 glucose transporters. RESULTS: Oral glucose tolerance test carried out in rodents showed that oral administration of RELM-beta increased glycemia. Studies in rat jejunal tissue indicated that mucosal RELM-beta promoted absorption of glucose from the gut lumen. RELM-beta had no effect on paracellular mannitol transport, suggesting a transporter-mediated transcellular mechanism. In studies with jejunal mucosa mounted in Ussing chamber, luminal RELM-beta inhibited SGLT-1 activity in line with a diminished SGLT-1 abundance in brush border membranes (BBMs). Further, the potentiating effect of RELM-beta on jejunal glucose uptake was associated with an increased abundance of GLUT2 at BBMs. The effects of RELM-beta were associated with an increased amount of protein kinase C betaII in BBMs and an increased phosphorylation of AMP-activated protein kinase (AMPK). CONCLUSIONS: The regulation of SGLT-1 and GLUT2 by RELM-beta expands the role of gut hormones in short-term AMPK/protein kinase C mediated control of energy balance
Dental management considerations for the patient with an acquired coagulopathy. Part 1: Coagulopathies from systemic disease
Current teaching suggests that many patients are at risk for prolonged bleeding during and following invasive dental procedures, due to an acquired coagulopathy from systemic disease and/or from medications. However, treatment standards for these patients often are the result of long-standing dogma with little or no scientific basis. The medical history is critical for the identification of patients potentially at risk for prolonged bleeding from dental treatment. Some time-honoured laboratory tests have little or no use in community dental practice. Loss of functioning hepatic, renal, or bone marrow tissue predisposes to acquired coagulopathies through different mechanisms, but the relationship to oral haemostasis is poorly understood. Given the lack of established, science-based standards, proper dental management requires an understanding of certain principles of pathophysiology for these medical conditions and a few standard laboratory tests. Making changes in anticoagulant drug regimens are often unwarranted and/or expensive, and can put patients at far greater risk for morbidity and mortality than the unlikely outcome of postoperative bleeding. It should be recognised that prolonged bleeding is a rare event following invasive dental procedures, and therefore the vast majority of patients with suspected acquired coagulopathies are best managed in the community practice setting
Reconfiguration, contestation, and decline: conceptualizing mature large technical systems
Large technical systems (LTS) are integral to modern lifestyles but arduous to analyze. In this paper, we advance a conceptualization of LTS using the notion of mature “phases,” drawing from insights into innovation studies, science and technology studies, political science, the sociology of infra- structure, history of technology, and governance. We begin by defining LTS as a unit of analysis and explaining its conceptual utility and novelty, situating it among other prominent sociotechnical theories. Next, we argue that after LTS have moved through the (overlapping) phases proposed by Thomas Hughes of invention, expansion, growth, momentum, and style,mature LTS undergo the additional (overlapping) phases of reconfiguration, contestation (subject to pressures such as drift and crisis), and eventually stagnation and decline. We illustrate these analytical phases with historical case studies and the conceptual literature, and close by suggesting future research to refine and develop the LTS framework, particularly related to more refined typologies, temporal dimensions, and a broadening of system users. We aim to contribute to theoretical debates about the coevolution of LTS as well as empirical discussions about system-related use, socio- technical change, and policy-making
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