Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation

We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells. By itself it induced a modest degree of B cell proliferation, but together with anti-immunoglobulin (anti-Ig) antibody it greatly stimulated B cell proliferation, as determined by both [3H]thymidine uptake and increase in cell numbers. These data are evidence that the CD40 ligand on T cells provides a signal that drives B cell proliferation. This signal is synergistic with that delivered by anti-Ig antibody

Using aircraft measurements to determine the refractive index of Saharan dust during the DODO Experiments

Much uncertainty in the value of the imaginary part of the refractive index of mineral dust contributes to uncertainty in the radiative effect of mineral dust in the atmosphere. A synthesis of optical, chemical and physical in-situ aircraft measurements from the DODO experiments during February and August 2006 are used to calculate the refractive index mineral dust encountered over West Africa. Radiative transfer modeling and measurements of broadband shortwave irradiance at a range of altitudes are used to test and validate these calculations for a specific dust event on 23 August 2006 over Mauritania. Two techniques are used to determine the refractive index: firstly a method combining measurements of scattering, absorption, size distributions and Mie code simulations, and secondly a method using composition measured on filter samples to apportion the content of internally mixed quartz, calcite and iron oxide-clay aggregates, where the iron oxide is represented by either hematite or goethite and clay by either illite or kaolinite. The imaginary part of the refractive index at 550 nm (ni550) is found to range between 0.0001 i to 0.0046 i, and where filter samples are available, agreement between methods is found depending on mineral combination assumed. The refractive indices are also found to agree well with AERONET data where comparisons are possible. ni550 is found to vary with dust source, which is investigated with the NAME model for each case. The relationship between both size distribution and ni550 on the accumulation mode single scattering albedo at 550 nm (ω0550) are examined and size distribution is found to have no correlation to ω0550, while ni550 shows a strong linear relationship with ω0550. Radiative transfer modeling was performed with different models (Mie-derived refractive indices, but also filter sampling composition assuming both internal and external mixing). Our calculations indicate that Mie-derived values of ni550 and the externally mixed dust where the iron oxide-clay aggregate corresponds to the goethite-kaolinite combination result in the best agreement with irradiance measurements. The radiative effect of the dust is found to be very sensitive to the mineral combination (and hence refractive index) assumed, and to whether the dust is assumed to be internally or externally mixed

Hard x-ray polarimetry with the Ramaty High Energy Solar Spectroscopic Imager (RHESSI)

Although designed primarily as a hard X-ray imager and spectrometer, the Ramaty High Energy Solar Spectroscopic Imager (RHESSI) is also capable of measuring the polarization of hard X-rays (20-100 keV) from solar flares. This capability arises from the inclusion of a small unobstructed Be scattering element that is strategically located within the cryostat that houses the array of nine germanium detectors. The Ge detectors are segmented, with both a front and rear active volume. Low energy photons (below about 100 keV) can reach a rear segment of a Ge detector only indirectly, by scattering. Low energy photons from the Sun have a direct path to the Be and have a high probability of Compton scattering into a rear segment of a Ge detector. The azimuthal distribution of these scattered photons carries with it a signature of the linear polarization of the incident flux. Sensitivity estimates, based on simulations and in-flight background measurements, indicate that a 20-100 keV polarization sensitivity of less than a few percent can be achieved for X-class flares

Stability analysis of polarized domains

Polarized ferrofluids, lipid monolayers and magnetic bubbles form domains with deformable boundaries. Stability analysis of these domains depends on a family of nontrivial integrals. We present a closed form evaluation of these integrals as a combination of Legendre functions. This result allows exact and explicit formulae for stability thresholds and growth rates of individual modes. We also evaluate asymptotic behavior in several interesting limits.Comment: 12 pages, 3 figures, Late

Minimal Conflicting Sets for the Consecutive Ones Property in ancestral genome reconstruction

A binary matrix has the Consecutive Ones Property (C1P) if its columns can be ordered in such a way that all 1's on each row are consecutive. A Minimal Conflicting Set is a set of rows that does not have the C1P, but every proper subset has the C1P. Such submatrices have been considered in comparative genomics applications, but very little is known about their combinatorial structure and efficient algorithms to compute them. We first describe an algorithm that detects rows that belong to Minimal Conflicting Sets. This algorithm has a polynomial time complexity when the number of 1's in each row of the considered matrix is bounded by a constant. Next, we show that the problem of computing all Minimal Conflicting Sets can be reduced to the joint generation of all minimal true clauses and maximal false clauses for some monotone boolean function. We use these methods on simulated data related to ancestral genome reconstruction to show that computing Minimal Conflicting Set is useful in discriminating between true positive and false positive ancestral syntenies. We also study a dataset of yeast genomes and address the reliability of an ancestral genome proposal of the Saccahromycetaceae yeasts.Comment: 20 pages, 3 figure

The MASSIVE Survey - III. Molecular gas and a broken Tully-Fisher relation in the most massive early-type galaxies

In this work we present CO(1-0) and CO(2-1) observations of a pilot sample of 15 early-type galaxies (ETGs) drawn from the MASSIVE galaxy survey, a volume-limited integral-field spectroscopic study of the most massive ETGs ($M_* >10^{11.5}M_\odot$) within 108 Mpc. These objects were selected because they showed signs of an interstellar medium and/or star formation. A large amount of gas ($>$2$\times$10$^8$ M$_{\odot}$) is present in 10 out of 15 objects, and these galaxies have gas fractions higher than expected based on extrapolation from lower mass samples. We tentatively interpret this as evidence that stellar mass loss and hot halo cooling may be starting to play a role in fuelling the most massive galaxies. These MASSIVE ETGs seem to have lower star-formation efficiencies (SFE=SFR/M$_{\rm H2}$) than spiral galaxies, but the SFEs derived are consistent with being drawn from the same distribution found in other lower mass ETG samples. This suggests that the SFE is not simply a function of stellar mass, but that local, internal processes are more important for regulating star formation. Finally we used the CO line profiles to investigate the high-mass end of the Tully-Fisher relation (TFR). We find that there is a break in the slope of the TFR for ETGs at high masses (consistent with previous studies). The strength of this break correlates with the stellar velocity dispersion of the host galaxies, suggesting it is caused by additional baryonic mass being present in the centre of massive ETGs. We speculate on the root cause of this change and its implications for galaxy formation theories.Comment: 13 pages, 7 figures, accepted by MNRA

‘‘There’s so much more to it than what I initially thought’’: Stepping into researchers’ shoes with a class activity in a first year psychology survey course

In psychology, it is widely agreed that research methods, although central to the discipline, are particularly challenging to learn and teach, particularly at introductory level. This pilot study explored the potential of embedding a student-conducted research activity in a one-semester undergraduate Introduction to Psychology survey course, with the aims of (a) engaging students with the topic of research methods; (b) developing students’ comprehension and application of research methods concepts; and (c) building students’ ability to link research with theory. The research activity explored shoe ownership, examining gender differences and relationships with age, and linking to theories of gender difference and of consumer identity. The process of carrying out the research and reflecting on it created a contextualized, active learning environment in which students themselves raised many issues that research methods lectures seek to cover. Students also wrote richer assignments than standard first year mid-term essay

THE INCIDENCE OF THE INFRAPATELLAR PLICAE IN THE ELDERLY WELSH POPULATION

There are several studies reporting the incidence of suprapatellar, medial and lateral plicae, but there is very limited information regarding the incidence of the infrapatellar plica. The purpose of our study was to record the incidence of the infrapatelar plicae in the elderly Welsh population suffering of knee osteoarthritis. A prospective study was performed and 90 knees with severe osteoarthritis of the knee joint (Kellgren-Lawrence type III and IV) were investigated during total knee arthroplasty surgery.  Documentation was performed at every total knee replacement surgery for the length of the study. Knee replacement was performed by one senior surgeon. Infrapatellar plica was investigated by a medial parapatellar approach and was classified into five types according to Kim’s classification. The overall incidence of the infrapatellar plicae was 37.7%. The most common type of plicae was the separate type (23.3 %). There was no significant difference found between male and female patients. The fenestra type was the least common (2.22%). The incidence of infrapatellar plicae in the elderly Welsh population suffering of knee osteoarthritis was significantly lower when compared to a study that recorded the incidence of infrapatellar plica in young patients. Possibly, the degenerative changes of the knee joint can cause the reabsorption of the infrapatellar plica decreasing by this way its incidence in the elderly population.Key words: infrapatellar plicae, incidence, knee osteoarthritis, elderl

Simulations of isoprene: Ozone reactions for a general circulation/chemical transport model

A parameterized reaction mechanism has been created to examine the interactions between isoprene and other tropospheric gas-phase chemicals. Tests of the parameterization have shown that its results match those of a more complex reaction set to a high degree of accuracy. Comparisons between test runs have shown that the presence of isoprene at the start of a six day interval can enhance later ozone concentrations by as much as twenty-nine percent. The test cases used no input fluxes beyond the initial time, implying that a single input of a biogenic hydrocarbon to an airmass can alter its ozone chemistry over a time scale on the order of a week

Challenger STS-17 (41-G) post-flight best estimate trajectory products: Development and summary results

Results from the STS-17 (41-G) post-flight products are presented. Operational Instrumentation recorder gaps, coupled with the limited tracking coverage available for this high inclination entry profile, necessitated selection of an anchor epoch for reconstruction corresponding to an unusually low altitude of h approx. 297 kft. The final inertial trajectory obtained, BT17N26/UN=169750N, is discussed in Section I, i.e., relative to the problems encountered with the OI and ACIP recorded data on this Challenger flight. Atmospheric selection, again in view of the ground track displacement from the remote meteorological sites, constituted a major problem area as discussed in Section II. The LAIRS file provided by Langley was adopted, with NOAA data utilized over the lowermost approx. 7 kft. As discussed in Section II, the Extended BET, ST17BET/UN=274885C, suggests a limited upper altitude (H approx. 230 kft) for which meaningful flight extraction can be expected. This is further demonstrated, though not considered a limitation, in Section III wherein summary results from the AEROBET (NJ0333 with NJ0346 as duplicate) are presented. GTFILEs were generated only for the selected IMU (IMU2) and the Rate Gyro Assembly/Accelerometer Assembly data due to the loss of ACIP data. Appendices attached present inputs for the generation of the post-flight products (Appendix A), final residual plots (Appendix B), a two second spaced listing of the relevant parameters from the Extended BET (Appendix C), and an archival section (Appendix D) devoting input (source) and output files and/or physical reels