Associations between recalled use of legal UK youth gambling products and adult disordered gambling

Background and aims: The UK allows a number of gambling products to be legally used by people under the age of 18. The aim of this study was to explore associations between recalled legal usage of five youth gambling products and adult disordered gambling. Methods: A retrospective cross-sectional study of 1,057 adult UK gamblers, aged 18–40. Recalled legal use of five youth gambling products (category D fruit machines, coin push machines, crane grab machines, the National Lottery, and National Lottery scratchcards) was correlated with adult disordered gambling symptoms as measured by the Problem Gambling Severity Index (PGSI). Results: Recalled rates of legal engagement with each product ranged from 50.9% for Category D fruit machines to 96.6% for coin push machines. For category D fruit machines, the National Lottery, and National Lottery scratchcards, merely having legally engaged with these products as a child was associated with adult disordered gambling. Furthermore, higher levels of recalled legal youth usage with each of the five products was also associated with adult disordered gambling. Discussion and conclusions: These results relate to recent government proposals to increase the National Lottery scratchcard legal age to 18, and add to a wider literature on youth gambling and subsequent gambling-related harm

Treatment of patients with distant metastases from phyllodes tumor of the breast

BACKGROUND: Here, the treatment methods and results of patients with phyllodes tumor of the breast (PT) with distant metastases at a single institution are presented. METHODS: A retrospective analysis was performed on a group of 295 patients with PT treated from 1952 to 2010. RESULTS: Distant metastases developed in 37 (12.5 %) patients; 3/160 (1.9 %) patients had benign PT, 6/36 (16.7 %) were considered borderline, and 28/99 (28.3 %) had malignant PT. Most frequently, the metastases were located in the lungs; 28 (75.7 %), bone 7 (18.9 %), brain 4 (10.8 %), and liver 2 (5.4 %). Metastases occurred on overage 21 months (2–57) after surgery. Patients with lung metastases were generally treated with monochemotherapy or polychemotherapy. In one patient Testosterone and in two patients resection of metastases combined with Doxorubicin were used. Patients with bones or brain metastases were treated with palliative radiotherapy only or combined with Doxorubicin. The mean survival (MS) from diagnosis of distant metastases (DM) was 7 months (2–17). The longest mean survival in patients with bones metastases was 11.8 months, the worst survival was for patients with brain metastases—2.8 months. Hormone therapy appeared to have low efficacy (MS: 2 months) as well as monochemotherapy (MS: 3–5 months). Improved MS was obtained using Doxorubicin (7 months) and Doxorubicin with Cisplatin, Cyclophosphamide, or Ifosfamide (9 months). CONCLUSION: The prognosis of patients with DM from PT is poor. The role of surgery and irradiation of such patients is very limited. There appears to be no role for the use of hormone therapy. This study showed that polychemotherapy with Doxorubicin and Ifosfamide suggest that it might be more effective than once thought

History Dependent Phenomena in the Transverse Ising Ferroglass: the Free Energy Landscape

In this paper we investigate the relationship between glassy and ferromagnetic phases in disordered Ising ferromagnets in the presence of transverse magnetic fields, $\Gamma$. Iterative mean field simulations probe the free energy landscape and suggest the existence of a glass transition as a function of $\Gamma$ which is distinct from the Curie temperature. New experimental field-cooled and zero-field-cooled data on LiHo$_x$Y$_{1-x}$F$_4$ provide support for our theoretical picture.Comment: 4 pages RevTex; 5 figure

Replica analysis of the generalized p-spin interaction glass model

We investigate stability of replica symmetry breaking solutions in generalized $p$-spin models. It is shown that the kind of the transition to the one-step replica symmetry breaking state depends not only on the presence or absence of the reflection symmetry of the generalized "spin"-operators $\hat{U}$ but on the number of interacting operators and their individual characteristics.Comment: 14 pages, 1 figur

First-order transitions and triple point on a random p-spin interaction model

The effects of competing quadrupolar- and spin-glass orderings are investigated on a spin-1 Ising model with infinite-range random $p$-spin interactions. The model is studied through the replica approach and a phase diagram is obtained in the limit $p\to\infty$. The phase diagram, obtained within replica-symmetry breaking, exhibits a very unusual feature in magnetic models: three first-order transition lines meeting at a commom triple point, where all phases of the model coexist.Comment: 9 pages, 2 ps figures include