The Leukemia-Specific Fusion Gene ETV6/RUNX1 Perturbs Distinct Key Biological Functions Primarily by Gene Repression

-positive leukemic cell lines.-positive ALL samples underline the relevance of these pathways and molecular functions. We also validated six differentially expressed genes representing the categories “stem cell properties”, “B-cell differentiation”, “immune response”, “cell adhesion” and “DNA damage” with RT-qPCR. fusion gene interferes with key regulatory functions that shape the biology of this leukemia subtype. E/R may thus indeed constitute the essential driving force for the propagation and maintenance of the leukemic process irrespective of potential consequences of associated secondary changes. Finally, these findings may also provide a valuable source of potentially attractive therapeutic targets

Understanding the cancer stem cell

The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it was initially believed that only a rare population of stem cells are able to undergo self-renewing divisions and differentiate to form all populations within a malignancy, a recent work has shown that these cells may not be as rare as thought first, at least in some malignancies. Improved experimental models are beginning to uncover a less rigid structure to CSC biology, in which the concepts of functional plasticity and clonal evolution must be incorporated into the traditional models. Slowly the genetic programmes and biological processes underlying stem cell biology are being elucidated, opening the door to the development of drugs targeting the CSC. The aim of ongoing research to understand CSCs is to develop novel stem cell-directed treatments, which will reduce therapy resistance, relapse and the toxicity associated with current, non-selective agents

Doppler echocardiographic diagnosis and follow-up of acquired pulmonary stenosis due to external cardiac compression.

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Surface-Based 3D Modeling of Geological Structures

International audienceBuilding a 3D geological model from field and subsurface data is a typical task in geological studies involving natural resource evaluation and hazard assessment. However, there is quite often a gap between research papers presenting case studies or specific innovations in 3D modeling and the objectives of a typical class in 3D structural modeling, as more and more is implemented at universities. In this paper, we present general procedures and guidelines to effectively build a structural model made of faults and horizons from typical sparse data. Then we describe a typical 3D structural modeling workflow based on triangulated surfaces. Our goal is not to replace software user guides, but to provide key concepts, principles, and procedures to be applied during geomodeling tasks, with a specific focus on quality control

Holt Oram syndrome mistaken for thalidomide embryopathy--embryological considerations.

The reproductive history of a woman diagnosed as having a thalidomide syndrome clearly shows that she is affected by the Holt Oram syndrome (autosomal dominant inheritance). The problem of considering a phenocopy in genetic counselling is discussed. A study of the family illustrates the wide range of clinical manifestations of the Holt Oram syndrome. Embryological considerations are given. © 1982 Springer-Verlag.Case ReportsJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

A statistical approach to relationships between fluid emissions and faults: The Sea of Marmara case

International audienceThe Sea of Marmara is traversed by the North Anatolian Fault system and also presents abundant emission sites of methane gas into the water column. In order to assess the spatial relationship between gas emissions and active faults, the distribution of distances between gas emission sites and the nearest fault is calculated and compared with the distribution of distances between a uniform random distribution of points (Poisson process representing the null hypothesis of an absence of relationship between gas emissions and faults) and the nearest fault. Interestingly, the distance distribution for the Poisson process is nearly exponential, indicating that the fault map does not have a characteristic scale other than that representing the intensity of the fault network. The distance distribution for the observed gas emissions is significantly narrower than that arising from the Poisson process, with a Kolmogorov distance of 0.25 ± 0.02. The crossing point between the two distributions defines the characteristic half-width of the swath of gas emission sites around the mapped active faults. For the whole Sea of Marmara data set a characteristic half-width of 900–1000 m is found which matches the half-width of the seafloor deformation zone observed around the main active fault. When the same analysis is applied to zones covering the Western High and the Central High it is found that the swath of gas emissions is wider on the Central High (2 km half-width), and not clearly related to the seafloor deformation zone there. This difference is put in perspective with recent work showing that creep is occurring on the western segment of the Main Marmara Fault (this also causing microseismicity) while the central Istanbul-Silivri segment may have remained locked since the 1766 magnitude 7+ earthquake. This suggests that aseismic slip (and not only earthquake occurrence) effectively maintains high permeability conduits in fault zones in sediments

High or low dose steroid therapy for acute renal transplant rejection after prophylactic OKT3 treatment: a prospective randomized study

FLWNOinfo:eu-repo/semantics/publishe

A statistical approach to relationships between fluid emissions and faults: The Sea of Marmara case

The Sea of Marmara is traversed by the North Anatolian Fault system and also presents abundant emission sites of methane gas into the water column. In order to assess the spatial relationship between gas emissions and active faults, the distribution of distances between gas emission sites and the nearest fault is calculated and compared with the distribution of distances between a uniform random distribution of points (Poisson process representing the null hypothesis of an absence of relationship between gas emissions and faults) and the nearest fault. Interestingly, the distance distribution for the Poisson process is nearly exponential, indicating that the fault map does not have a characteristic scale other than that representing the intensity of the fault network. The distance distribution for the observed gas emissions is significantly narrower than that arising from the Poisson process, with a Kolmogorov distance of 0.25±0.02. The crossing point between the two distributions defines the characteristic half-width of the swath of gas emission sites around the mapped active faults. For the whole Sea of Marmara data set a characteristic half-width of 900–1000 m is found which matches the half-width of the seafloor deformation zone observed around the main active fault. When the same analysis is applied to zones covering the Western High and the Central High it is found that the swath of gas emissions is wider on the Central High (2 km half-width), and not clearly related to the seafloor deformation zone there. This difference is put in perspective with recent work showing that creep is occurring on the western segment of the Main Marmara Fault (this also causing microseismicity) while the central Istanbul-Silivri segment may have remained locked since the 1766 magnitude 7+ earthquake. This suggests that aseismic slip (and not only earthquake occurrence) effectively maintains high permeability conduits in fault zones in sediments