REFERENCE RANGE OF HEART RATE VARIABILITY AND VALIDATION IN SUBJECTS WITH ASYMPTOMATIC ELEVATED LIVER FUNCTION ENZYMES

The prevalence and severity of autonomic dysfunction appears to be related to the severity of liver disease (e. g. alcoholic cirrhosis) and is associated with an increase in mortality. This study aims to evaluate time domain parameters of heart rate variability in asymptomatic liver functions elevated healthy subjects and comparison of it with normal population reference range. The rationale of the study is that increasing severity of liver failure is associated with a reduction in total heart rate variability and regularity; therefore measurement of HRV offers a simple, noninvasive means of assessing the cardiovascular and autonomic effects of liver disease. The finding of the current study shows that Heart rate variability of Liver functions elevated subjects are found to be higher than the normal population reference range. The reason for finding of higher variability was that subjects included in this study had bradycardia. Bradycardia is known to lead to higher heart rate variability

Lack of association of PTPN1 gene polymorphisms with type 2 diabetes in South Indians

This article does not have an abstract

A Study on Relevance of Student's Attitude, Implementing an Interdisciplinary Approach in a Post Graduate Program

AbstractIn today's scenario most of the programs are interdisciplinary in nature. A very few ‘curriculum models’ are in place in the bibliography record to study the impact and implementation style. One such curriculum model SRU-2011 was implemented in the center identified and the output was reviewed. The usual problems related to Inter - Disciplinary Programs are unrelated subjects, growth of new fields of study, selection of different subjects, different impacting methods, student's impact and attitude issues. Of the above mentioned issues we found that a correlation exists between attitude related issues and student placement results. The outcome of these results and other related issues have been discussed

The Inter-Relation of Objective Assessment of The Bell’s Palsy with House-Brackmann Score: A Prospective Study

Introduction: Bell’s palsy is the most common acute peripheral mononeuropathy, which leads to the partial or complete inability to voluntary movement of the facial muscles on the affected side of the face. The study aimed to evaluate the objective assessment of the Bell’s palsy with House-Brackmann score. Methods: This Observational, Prospective study was to be conducted at tertiary care hospital among from June 2022 to September 2022 on 11 patients diagnosed with Bell’s Palsy. A patient’s history includes age, sex, and clinical features. Assessments include facial nerve grading system such as House-Brackmann score, which was used to grade the facial nerve severity. Results: Out of 11 patients, 7 patients of Bell’s Palsy (63%) were reported with Grade IV of House- Brackmann score. The remaining patients were scored under Grade III and Grade V. Patients of age group from 9 to 75 were taken. Among them, age group of 9-40 years were 45% and 40- 80 years were 55%. The result shows that Grade IV is predominant over others, male and elder patients are leading over female and middle- aged patients. 63.7% patient’s clinical features were come under Grade IV of House- Brackmann score. 27.2% of patients had an increased risk of hypertension, 18.1% had Diabetes Mellitus, 18.1% had past history of CVA, 9% had past history of Seizure, and known history of Bell ’s palsy. Conclusion: Using the House-Brackmann grading system, the severity of the patient presenting with Bell’s palsy could be reliably predicted

Natural Convection Heat Transfer in Enclosures With Multiple Vertical Partitions

of air or vacuum, N 2 = n + IK is the complex refractive index of the lamina material, and 9 2 is the (complex) angle of refraction, which is related to 9 t by Snell's law: N, sin #, = N 2 sin 9 2 . Since r 2l = -r i2 , the reflectance at both interfaces is equal to p = r n rf 2 , where * denotes the complex conjugate. The internal transmittance T is related to the (complex) phase change 6 by r = exp . After carefully examining the transmittance formulae of a lamina, this work shows that the geometric-optics formula may result in a significant error for a highly absorbing medium even in the incoherent limit (when interference effects are negligible). Introduction Consider the transmission of electromagnetic radiation through a lamina with smooth and parallel surfaces. In the incoherent limit when radiation coherence length is much smaller than the thickness of the lamina, the transmittance (or reflectance) may be obtained either by tracing the multiply reflected radiant power fluxes (ray-tracing method) or by separating the power flux at each interface into an outgoing component and an incoming component (net-radiation method), viz. ( where p is the reflectance at the interface and r is the internal transmittance. This formula is also called the geometric-optics formula since it is obtained without considering interference effects. For a plane wave, p equals the square of the absolute value of the complex Fresnel reflection coefficient (i.e., the ratio of the reflected electric field to the incident electric field at the interface). The Fresnel reflection coefficient is (Heavens, 1965) r\ 2 = { cos 9 2 -N 2 cos f?i JVi cos (2) N, cos 0, -N 2 cos 6*2 , . , for s -polarization ,7V, cos 9 t + N 2 cos 9 2 where 9 l is the angle of incidence, /V, = 1 is the refractive index where d is the lamina thickness and X is the wavelength in vacuum. In the coherent limit, the transmittance of a lamina may be obtained from thin-film optics (i.e., wave optics) either by tracing the reflected and transmitted waves (Airy's method) or by separating the electric fields into a forward-propagating component (forward wave) and a backward-propagating component (backward wave), viz. (Heavens, 1965; Analysis and Discussion The power transmittance at the interface between the air (or vacuum) and the medium (lamina) is where (1 + r !2 ) is the Fresnel transmission coefficient. The power transmittance at the second interface between the medium and the air can be obtained by exchanging the subscripts 1 and 2 in Eq. (6). At normal incidence, r 12 = (1 -n -('K)/(1 If both K and Im(r 21 ) are nonzero, T 2 \ =t= 1 -p. As discussed by Journal of Heat Transfer AUGUST 1997, Vol. 119/645 Copyright © 1997 by ASME Zhang The above equation is identical to Eq. (5). However, it is not a simple replacement of (1 -p) 2 in Eq. As an example, suppose the lamina is a LaA10 3 wafer of thickness d = 100 p,m. The optical constants are calculated from the Lorentian dielectric function determined by (1) and the transmittance for a LaA10 3 lamina at wavelengths from 9 to 14 p,m at normal incidence are shown in The difference between the wave-optics formula and the incoherent formula is shown in For a highly absorbing lamina (i.e., r < § 1), multiple reflections may be neglected. The transmittance obtained from Eq. (1), when multiple reflections are negligible, is (1 -pfr. The transmittance calculated from Eq. (8) for T < 1 is where the last expression is for normal incidence only. Eq. Concluding Remarks By inspecting the energy balance at the second interface, this work reveals an implicit assumption associated with Eq. Certain important applications require the determination of transmittance below 10~4. Examples are in the characterization of attenuation filters, bandpass filters, and materials with strong absorption bands Acknowledgments This work has been supported by the University of Florida through a start-up fund and an Interdisciplinary Research Initiative award. / Vol. 119, AUGUST 1997 Transactions of the ASME A. A., 1994, "Modelling of the Reflectance of Silicon," Infrared Physics and Technology, Vol. 35, pp. 701 -708. Frenkel, A" and Zhang, Z. M" 1994, "Broadband High Optical Density Filters in the Infrared," Optics Letters, Vol. 19, pp. 1495-1497 Gentile, T. R., Frenkel, A" Migdall, A. L., and Zhang, Z. M" 1995, "Neutral Density Filter Measurements at the National Institute of Standards and Technology," Spectrophotometry, Luminescence and Colour; Science and Compliance, C. Burgess and D. G. Jones, eds., Elsevier, Amsterdam, The Netherlands, pp. 129-139. Grossman, E. N" and McDonald, D. G" 1995, "Partially Coherent Transmittance of Dielectric Lamellae," Optical Engineering, Vol. 34, pp. 1289-1295. Heavens, O. S., 1965, Optical Properties of Thin Solid Films, Dover Publications, Inc., New York, chap. 4, pp. 46-95. Knittl, Z" 1976, Optical of Thin Films, John Wiley & Sons, Inc., NY, pp. 203-204. Salzberg, B., 1948, "A Note on the Significance of Power Reflection," American Journal of Physics, Vol. 16, pp. 444-446. Siegel, R" and Howell, J. R., 1992, Thermal Radiation Heat Transfer, 3rd ed" Hemisphere Publishing Corp., Washington D.C., chap. 4, p. 120, and chap. 18, pp. 928-930. Yeh, P., 1988, Optical Waves in Layered Media, John Wiley & Sons, Inc., New York, chap. 4, pp. 83-101. Zhang, Z. M., 199

Human performance and strategies while solving an aircraft routing and sequencing problem: an experimental approach

As airport resources are stretched to meet increasing demand for services, effective use of ground infrastructure is increasingly critical for ensuring operational efficiency. Work in operations research has produced algorithms providing airport tower controllers with guidance on optimal timings and sequences for flight arrivals, departures, and ground movement. While such decision support systems have the potential to improve operational efficiency, they may also affect users’ mental workload, situation awareness, and task performance. This work sought to identify performance outcomes and strategies employed by human decision makers during an experimental airport ground movement control task with the goal of identifying opportunities for enhancing user-centered tower control decision support systems. To address this challenge, thirty novice participants solved a set of vehicle routing problems presented in the format of a game representing the airport ground movement task practiced by runway controllers. The games varied across two independent variables, network map layout (representing task complexity) and gameplay objective (representing task flexibility), and verbal protocol, visual protocol, task performance, workload, and task duration were collected as dependent variables. A logistic regression analysis revealed that gameplay objective and task duration significantly affected the likelihood of a participant identifying the optimal solution to a game, with the likelihood of an optimal solution increasing with longer task duration and in the less flexible objective condition. In addition, workload appeared unaffected by either independent variable, but verbal protocols and visual observations indicated that high-performing participants demonstrated a greater degree of planning and situation awareness. Through identifying human behavior during optimization problem solving, the work of tower control can be better understood, which, in turn, provides insights for developing decision support systems for ground movement management

Inferring causal molecular networks: empirical assessment through a community-based effort

Inferring molecular networks is a central challenge in computational biology. However, it has remained unclear whether causal, rather than merely correlational, relationships can be effectively inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge that focused on learning causal influences in signaling networks. We used phosphoprotein data from cancer cell lines as well as in silico data from a nonlinear dynamical model. Using the phosphoprotein data, we scored more than 2,000 networks submitted by challenge participants. The networks spanned 32 biological contexts and were scored in terms of causal validity with respect to unseen interventional data. A number of approaches were effective and incorporating known biology was generally advantageous. Additional sub-challenges considered time-course prediction and visualization. Our results constitute the most comprehensive assessment of causal network inference in a mammalian setting carried out to date and suggest that learning causal relationships may be feasible in complex settings such as disease states. Furthermore, our scoring approach provides a practical way to empirically assess the causal validity of inferred molecular networks

Inferring causal molecular networks: empirical assessment through a community-based effort

It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge, which focused on learning causal influences in signaling networks. We used phosphoprotein data from cancer cell lines as well as in silico data from a nonlinear dynamical model. Using the phosphoprotein data, we scored more than 2,000 networks submitted by challenge participants. The networks spanned 32 biological contexts and were scored in terms of causal validity with respect to unseen interventional data. A number of approaches were effective, and incorporating known biology was generally advantageous. Additional sub-challenges considered time-course prediction and visualization. Our results suggest that learning causal relationships may be feasible in complex settings such as disease states. Furthermore, our scoring approach provides a practical way to empirically assess inferred molecular networks in a causal sense