718 research outputs found
Influence Of Wind Turbines On Mammalian Occupancy Patterns
Wind energy is among the most rapidly growing energy industries in the United States, with support for development coming from both state and federal governments. While the industry depicts an environmentally friendly image, the addition of infrastructure associated with wind farms alters landscapes in novel ways. Numerous studies have documented impacts wind turbines have on bird and bat mortality; however, far less attention has been directed towards responses of non-volant, terrestrial organisms. Mammalian mesocarnivores are model organisms to assess the alteration of communities surrounding wind turbines as they respond to addition of turbines and human activity, addition and improvement of roadways, and increases in turbine-induced carrion. In September 2011, I established a yearlong study surrounding the Central Plains Wind Facility in western Kansas to document patterns associated with the occupancy of terrestrial mammals within turbine and turbine-free habitats. I placed 34 scent-baited trail cameras among turbine and control habitats, with a randomly placed subset along roadways. Detection histories during 28-day survey periods and habitat covariates were analyzed with PRESENCE 5.5. Canis latrans and Vulpes velox were the most abundant mesocarnivores detected. Canis latrans had a higher probability of occupancy at the control area, while V. velox had higher probabilities of occupancy at the turbine area. Detection probabilities were impacted strongly by mean precipitation as well as between field and roadway locations for V. velox. Vulpes velox detection probabilities were conditional on C. latrans presence and detection, although the two species occupied sites independently
Sex-based differences in anti-predator response of crickets to chemical cues of a mammalian predator
Anti-predator behaviors like vigilance or hiding come at the expense of other fitness increasing behaviors such as foraging. To compensate for this trade-off, prey assess predation risk and modify the frequency of anti-predator behaviors according to the likelihood of the threat. In this study, we tested the ability of house crickets (Acheta domesticus) to indirectly assess predation risk via odors from a mammalian predator, Elliot\u27s short-tailed shrew (Blarina hylophaga). As natural differences in encounter rates and predation risk differs between sexes, we tested if male and female crickets perceive similar rates of predation risk from the presence of shrew odor measured via anti-predator behavioral response. Crickets were placed in enclosed, cardboard-lined chambers either treated with shrew odor or control, along with a food source. Time until foraging was measured for each individual and compared across treatment and sex. We found that in the presence of shrew odor, female crickets delayed foraging while males showed no response. These results suggest adult crickets can use chemical cues to detect mammalian predators. Furthermore, we demonstrate that female crickets associate greater predation risk from shrew predators than do male crickets, which are more stationary yet acoustically conspicuous. As predation risk potentially differs drastically for each sex, changes to the operational sex ratios of wild cricket populations could be influenced by the identity of the predator community
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Dogs, Death, and Dietary Breadth: Insights into the Macroecology and Macroevolution of Canidae
The size, shape, and stability of a species’ dietary niche can both influence and reflect a variety of biological patterns, including species interactions, extinction risk, and ecosystem function. This is particularly apparent when dietary changes manifest at ecosystem and clade scales to profoundly affect macroecological and macroevolutionary trajectories. However, many studies exploring interactions, extinction, and ecosystem function rarely take into account dietary breadth across broad temporal and spatial scales, despite the fact that many ecological processes unfold over temporal and spatial scales that are beyond the scope of traditional ecology. This dissertation addresses this gap by testing the hypothesized drivers of two macroecological and macroevolutionary patterns using dietary niche breadth reconstructed from historical and paleontological canid specimens. Canid predators represent a model system for exploring broad patterns of ecology and evolution given their strong interspecific interactions coupled with a historical legacy of human-driven exterminations resulting in novel community dynamics. Additionally, North American canids offer a rich and diverse fossil history complete with iterative patterns of extinction and radiation used to describe macroevolutionary theory. I quantified dietary niche breadth for western North American canids via stable isotope analysis (SIA) and dental microwear texture analysis (DMTA) and applied these techniques across the spatial and temporal extent of canid distributions. Across space, I explored how mesopredator release has altered the dietary niche breadth of coyotes following the historical extirpation of gray wolves from the Pacific Northwest. Through time, I utilized the 33 million years of evolutionary history preserved in the North American canid fossil record to test the hypothesized link between dietary breadth and the ultimate extinction of canid lineages. In order to make more complete use of fossil, historical, and modern museum collections, which can contain fragmentary specimens, I also developed a novel approach to DMTA, devised to increase sample sizes while not biasing reconstructed dietary behaviors. I demonstrated that multiple facets along the cheek teeth in canids yield comparable microwear signals regardless of molar type or bite force (chapter 2). Thus scans from multiple molars can be combined to increase sample sizes among taxa with limited material. Looking across a latitudinal gradient along Western North America, I found that coyotes sympatric with wolves have reduced dietary niche breadth compared with coyotes sympatric with wolves. Furthermore, DMTA and SIA independently suggest released coyotes increased dietary plasticity following a reduction in scavenging behavior, previously facilitated by wolves (chapter 3). Extinction risk has been hypothesized to be positively correlated with dietary specialization, known as the macroevolutionary ratchet. The fossil record of canids has revealed iterative ratchets as multiple clades evolved towards hypercarnivory followed by rapid lineage extinctions. Morphological traits previously used to describe the macroevolutionary ratchet in canid evolution, however, are unable to capture the dietary breadth of a species. I found morphological traits were inferior to DMTA parameters at explaining extinction risk. Counter to expectations, I observed a positive correlation between specialization and lineage duration and that specialization was not correlated with traditionally-used dietary categories, suggesting that overspecialization in diet alone did not drive iterative extinctions in canids. Outcomes of this dissertation offer direct hypotheses for management officials dealing with proliferating mesopredators and trophic restructuring today. Additionally, my temporal analysis advances our fundamental understanding of macroevolutionary ratchets, and will enable future community-level studies of how species interactions influenced past evolutionary trajectories
Outcomes of patients with perforated colon cancer:A systematic review
Introduction: Perforated colon cancer (PCC) is a distinct clinical entity with implications for treatment and prognosis, however data on PCC seems scarce. The aim of this systematic review is to provide a comprehensive overview of the recent literature on clinical outcomes of PCC. Materials and methods: A systematic literature search of MEDLINE (PubMed), Embase, Cochrane library and Google scholar was performed. Studies describing intentionally curative treatment for patients with PCC since 2010 were included. The main outcome measures consisted of short-term surgical complications and long-term oncological outcomes. Results: Eleven retrospective cohort studies were included, comprising a total of 2696 PCC patients. In these studies, various entities of PCC were defined. Comparative studies showed that PCC patients as compared to non-PCC patients have an increased risk of 30-day mortality (8–33% vs 3–5%), increased post-operative complications (33–56% vs 22–28%), worse overall survival (36–40% vs 48–65%) and worse disease-free survival (34–43% vs 50–73%). Two studies distinguished free-perforations from contained perforations, revealing that free-perforation is associated with significantly higher 30-day mortality (19–26% vs 0–10%), lower overall survival (24–28% vs 42–64%) and lower disease-free survival (15% vs 53%) as compared to contained perforations. Conclusion: Data on PCC is scarce, with various PCC entities defined in the studies included. Heterogeneity of the study population, definition of PCC and outcome measures made pooling of the data impossible. In general, perforation, particularly free perforation, seems to be associated with a substantial negative effect on outcomes in colon cancer patients undergoing surgery. Better definition and description of the types of perforation in future studies is essential, as outcomes seem to differ between types of PCC and might require different treatment strategies.</p
Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample
© 2017 The Authors Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County, Minnesota, residents, aged 70 to 89 years with probable RBD. Here, we examine their progression to dementia and other neurodegenerative phenotypes. Methods Fifteen participants with RBD who were diagnosed with either MCI or PD were longitudinally followed, and their subsequent clinical courses were reviewed. Results Over 6.4 ± 2.9 years, six of the 14 participants with MCI developed additional neurodegenerative signs, five of whom had Lewy body disease features. Four of them progressed to dementia at a mean age 84.8 ± 4.9 years, three of whom met the criteria for probable dementia with Lewy bodies. One subject with PD developed MCI, but not dementia. Discussion Our findings from the population-based sample of Olmsted County, Minnesota, residents suggest that a substantial number of RBD patients tend to develop overt synucleinopathy features over time, and RBD patients who develop MCI and subsequent dementia have clinical features most consistent with dementia with Lewy bodies
Dielectronic Recombination of Ground-State and Metastable Li+ Ions
Dielectronic recombination has been investigated for Delta-n = 1 resonances
of ground-state Li+(1s^2) and for Delta-n = 0 resonances of metastable Li+(1s2s
^3S). The ground-state spectrum shows three prominent transitions between 53
and 64 eV, while the metastable spectrum exhibits many transitions with
energies < 3.2 eV. Reasonably good agreement of R-matrix, LS coupling
calculations with the measured recombination rate coefficient is obtained. The
time dependence of the recombination rate yields a radiative lifetime of 52.2
+- 5.0 s for the 2 ^3S level of Li+.Comment: Submitted to Phys. Rev. A; REVTeX, 4 pages, 3 figure
Phase I study of gemcitabine using a once every 2 weeks schedule.
Gemcitabine (2',2'-difluorodeoxycytidine) is a novel nucleoside analogue. As part of a series of studies to determine the maximum tolerated dose (MTD) of gemcitabine and the most appropriate schedule, a two-centre phase I study of gemcitabine was undertaken in patients with advanced refractory solid tumours using a once every 2 weeks schedule. Fifty-two patients were entered into the study at 14 different dose levels (40-5700 mg m-2). Weekly evaluations for toxicity were performed and the MTD for this once every 2 weeks schedule was 5700 mg m-2. The dose-limiting toxicity was myelosuppression, with neutropenia being most significant. Other toxicities were nausea, vomiting, fever and asthenia. One minor response was seen in a heavily pretreated breast cancer patient treated at 1200 mg m-2. Preclinical studies suggest that the efficacy of gemcitabine is more schedule than dose related, and it is concluded that this is not the most appropriate dosing schedule for gemcitabine. However, this study demonstrates the safety profile of gemcitabine, as doses over fourfold greater than that recommended for the weekly schedule of 1000 mg m-2 could be tolerated
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Dental microwear textures across cheek teeth in canids: Implications for dietary studies of extant and extinct canids
Dental microwear texture analysis (DMTA) has been instrumental in reconstructing dietary ecology of extinct and extant carnivorans. Current sampling methods for canids focus on lower second molars (m2), where the grinding of flesh and bone captures dental microwear indicative of diet. However, dental microwear on other biomechanically analogous grinding facets (i.e. the talonid basin on the lower carnassial, m1) might be comparable and could help dramatically increase sample sizes of fossil specimens, as carnassials are more frequently recovered and identifiable than lower m2s. Here, we quantify the degree to which dental microwear textures between grinding facets on lower first and second molars are similar in two species of extant canids, coyotes (Canis latrans) and gray wolves (Canis lupus). Casts of paired m1s and m2s for each individual were sampled from museum collections and analyzed for three microwear parameters that correlate with diet in carnivorans: anisotropy, complexity, and textural fill volume. Within wolves, the m1 talonid and m2 are indistinguishable in all DMTA parameters. In coyotes, grinding facets of the ml talonid and m2 are indistinguishable in complexity and textural fill volume, but anisotropy values of m1s are significantly lower than those of m2s. Differences in anisotropy between species were unlikely to be driven by biomechanical shifts in bite force between the ml talonid and m2, but could stem from a combination of subtle morphological variation and intra-tooth variation. Overall, these data suggest that regions across molars with similar functions yield similar dental microwear textures. Finally, to demonstrate the effect of increased sample size, we show how the combination of DMTA data from lower m1 talonids and lower m2s of the hypocarnivorous Phlaocyonini canids from the John Day Formation of eastern Oregon, USA, alters the size and shape, but not position, of their reconstructed dietary "niche" space and hence interpretations about dietary behavior
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