Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping

Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course.info:eu-repo/semantics/publishedVersio

Monitorização do desempenho de operadores de parques eólicos portugueses

Neste estudo utilizam-se modelos de DEA para avaliar o desempenho dos parques eólicos pertencentes a dois operadores presentes no setor energético Português de forma a apoiar o benchmarking e a melhoria das práticas durante a operação dos parques. Pretende-se comparar o desempenho dos dois operadores em termos da capacidade dos parques maximizarem a produção de energia a partir dos recursos disponíveis e do potencial eólico. Esta metodologia permite quantificar as diferenças entre os operadores relativas ao posicionamento das fronteiras e à dispersão da eficiência verificada para os parques pertencentes a cada um deles

Dynamics of Snoring Sounds and Its Connection with Obstructive Sleep Apnea

Snoring is extremely common in the general population and when irregular may indicate the presence of obstructive sleep apnea. We analyze the overnight sequence of wave packets --- the snore sound --- recorded during full polysomnography in patients referred to the sleep laboratory due to suspected obstructive sleep apnea. We hypothesize that irregular snore, with duration in the range between 10 and 100 seconds, correlates with respiratory obstructive events. We find that the number of irregular snores --- easily accessible, and quantified by what we call the snore time interval index (STII) --- is in good agreement with the well-known apnea-hypopnea index, which expresses the severity of obstructive sleep apnea and is extracted only from polysomnography. In addition, the Hurst analysis of the snore sound itself, which calculates the fluctuations in the signal as a function of time interval, is used to build a classifier that is able to distinguish between patients with no or mild apnea and patients with moderate or severe apnea

Analisador granulométrico de solos.

bitstream/CNPDIA/9835/1/CT05_96.pdfEntrada padronizada: MACEDO, A