305 research outputs found
RSFQ devices with selective dissipation for quantum information processing
We study the possibility to use frequency dependent damping in RSFQ circuits
as means to reduce dissipation and consequent decoherence in RSFQ/qubit
circuits. We show that stable RSFQ operation can be achieved by shunting the
Josephson junctions with an circuit instead of a plain resistor. We derive
criteria for the stability of such an arrangement, and discuss the effect on
decoherence and the optimisation issues. We also design a simple flux generator
aimed at manipulating flux qubits
Evidence of Cooper pair pumping with combined flux and voltage control
We have experimentally demonstrated pumping of Cooper pairs in a
single-island mesoscopic structure. The island was connected to leads through
SQUID (Superconducting Quantum Interference Device) loops. Synchronized flux
and voltage signals were applied whereby the Josephson energies of the SQUIDs
and the gate charge were tuned adiabatically. From the current-voltage
characteristics one can see that the pumped current increases in 1e steps which
is due to quasiparticle poisoning on the measurement time scale, but we argue
that the transport of charge is due to Cooper pairs.Comment: 4 page
Superconducting microstrip detectors
Superconducting NbN microstrip counters feature radiation hardness two orders of magnitude higher than conventional Si strip detectors, spatial resolution limited only by lithographic techniques (0.1 - 2 microns), intrinsic signal rise time of 2 ps, and signal transport over large distances without losses. The aim of this proposal is to improve understanding of the physics of such detectors and to establish their large- scale feasibility
Convergent development of low-relatedness supercolonies in Myrmica ants.
Many ant species have independently evolved colony structures with multiple queens and very low relatedness among nestmate workers, but it has remained unclear whether low-relatedness kin structures can repeatedly arise in populations of the same species. Here we report a study of Danish island populations of the red ant Myrmica sulcinodis and show that it is likely that such repeated developments occur. Two microsatellite loci were used to estimate genetic differentiation (F(ST)) among three populations and nestmate relatedness within these populations. The F(ST) values were highly significant due to very different allele frequencies among the three populations with relatively few common alleles and relatively many rare alleles, possibly caused by single queen foundation and rare subsequent immigration. Given the isolation of the islands and the low investment in reproduction, we infer that each of the populations was most likely established by a single queen, even though all three extant populations now have within-colony relatedness 95%), and the genetic differentiation of nests showed a significantly positive correlation with the distance between them. Both male-biased sex-ratio and genetic viscosity are expected characteristics of populations where queens have very local dispersal and where new colonies are initiated through nest-budding. Based on a comparison with other M. sulcinodis populations we hypothesise a distinct succession of population types and suggest that this may be a possible pathway to unicoloniality, ie, development towards a complete lack of colony kin structure and unrelated nestmate workers
Superconducting NbN microstrip detectors
Superconducting NbN strip transmission line counters and coupling circuits were processed on silicon wafers using thin film techniques, and they were characterized with several methods to verify the design principles. The stripline circuits, designed using microwave design rules, were simulated using a circuit design tool enhanced to include modelling of the superconducting lines. The strips, etched out of the 282 nm thick top NbN film with resistivity 284 ”?cm at 20 K, have critical temperatures in the range 12 to 13 K and a critical current density approximately Jc(0) = 3.3·105 A/cm2. The linearized heat transfer coefficient between the strip and the substrate is approximately 1.1·105 W/(m2K) and the healing length is about 1.6 ”m between 3 and 5 K temperatures. Traversing 5 MeV a-particles caused the strips to quench. No events due to electrons could be detected in agreement with the predicted signal amplitude which is below the noise threshold of our wideband circuitry. The strip bias current and hence the signal amplitude were limited due to a microbridge at the isolator step of the impedance transformer
The Late Medieval Church and Graveyard at Ii Hamina, Northern Ostrobothnia, Finland â Pollen and macro remains from graves
The historical Ostrobothnian (Finland) burial tradition is poorly known, particularly when discussed from the environmental archaeological viewpoint.
This article examines Late Medieval burial methods in Ii Hamina village using
both micro- and macrofossil analyses incorporated into archaeological work.
This research provides information on the continuity of burial methods that
were sustained through the medieval period and into modern times. Burial
tradition patterns in the Northern Ostrobothnia region exhibit widely recognised characteristics, but also contain some local features
Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000-14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries.
BACKGROUND
Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0-14 years) and adults (aged 15-99 years) diagnosed with a haematological malignancy during 2000-14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in young patients (aged 0-24 years).
METHODS
We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3 that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0-14 years), adolescents (15-19 years), and young adults (20-24 years). We categorised leukaemia subtypes according to the International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs, using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age survival estimates were standardised to the marginal distribution of young people with leukaemia included in the analysis.
FINDINGS
164â563 young people were included in this analysis: 121â328 (73·7%) children, 22â963 (14·0%) adolescents, and 20â272 (12·3%) young adults. In 2010-14, the most common subtypes were lymphoid leukaemia (28â205 [68·2%] patients) and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and young adults for all leukaemias combined during 2010-14 varied widely, ranging from 46% in Mexico to more than 85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better age-standardised survival (from 43% in Ecuador to â„80% in parts of Europe, North America, Oceania, and Asia) than those with acute myeloid leukaemia (from 32% in Peru to â„70% in most high-income countries in Europe, North America, and Oceania). Throughout 2000-14, survival from all leukaemias combined remained consistently higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young adults in most countries.
INTERPRETATION
This study offers the first worldwide picture of population-based survival from leukaemia in children, adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators of the quality of cancer management in this age group.
FUNDING
Children with Cancer UK, the Institut National du Cancer, La Ligue Contre le Cancer, Centers for Disease Control and Prevention, Swiss Re, Swiss Cancer Research foundation, Swiss Cancer League, Rossy Family Foundation, US National Cancer Institute, and the American Cancer Society
- âŠ