Electrocardiographic early repolarization characteristics and clinical presentations in the young: a benign finding or worrisome marker for arrhythmias

BackgroundThe early ECG repolarization QRS pattern (ERp), with J‐point elevation of 0.1 mV in two contiguous inferior and/or lateral leads, can be associated with ventricular arrhythmias among adults. The significance of an ERp in the young is unknown.ObjectiveThe purpose of this study was to assess the prevalence of ERp among young patients (pts), describe and correlate the characteristics with clinical presentations and any arrhythmias.MethodsThis was a 1 y retrospective review of ECGs obtained from patients referred specifically for documented arrhythmias, possible arrhythmia‐related symptoms or sports clearance. ECGs were analyzed for ERp (J‐point, ascending/horizontal patterns, location) and correlated with presenting complaints.ResultsOf 301 patient ECGs, an ERp was found in 177 (59%), (pts age 11.7 ± 4.3 y); 54% male; 23% Caucasian. Of these, 6 pts had a family history of sudden cardiac death. Arrhythmias (72% atrial) occurred in 22 pts. Only 3 pts had ventricular arrhythmias (1 successfully ablated). The ascending ST segment and elevated J‐point occurred in 77% and 51% of pts with and without arrhythmias respectively. In 73% of all pts, the ERp location was in inferior/lateral leads. Neither gender, ethnicity, large J‐point, lead location, nor the combination of a horizontal ST segment with large J‐point correlated with any arrhythmias.ConclusionsERp, especially the diffuse ascending pattern, is common among the young, in those of European ethnicity, found equally in both genders, and with no apparent correlation with atrial nor ventricular arrhythmias.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136329/1/chd12410.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136329/2/chd12410_am.pd

The THREAT-ARREST Cyber-Security Training Platform

Cyber security is always a main concern for critical infrastructures and nation-wide safety and sustainability. Thus, advanced cyber ranges and security training is becoming imperative for the involved organizations. This paper presets a cyber security training platform, called THREAT-ARREST. The various platform modules can analyze an organization’s system, identify the most critical threats, and tailor a training program to its personnel needs. Then, different training programmes are created based on the trainee types (i.e. administrator, simple operator, etc.), providing several teaching procedures and accomplishing diverse learning goals. One of the main novelties of THREAT-ARREST is the modelling of these programmes along with the runtime monitoring, management, and evaluation operations. The platform is generic. Nevertheless, its applicability in a smart energy case study is detailed

Flexible and Robust Privacy-Preserving Implicit Authentication

Implicit authentication consists of a server authenticating a user based on the user's usage profile, instead of/in addition to relying on something the user explicitly knows (passwords, private keys, etc.). While implicit authentication makes identity theft by third parties more difficult, it requires the server to learn and store the user's usage profile. Recently, the first privacy-preserving implicit authentication system was presented, in which the server does not learn the user's profile. It uses an ad hoc two-party computation protocol to compare the user's fresh sampled features against an encrypted stored user's profile. The protocol requires storing the usage profile and comparing against it using two different cryptosystems, one of them order-preserving; furthermore, features must be numerical. We present here a simpler protocol based on set intersection that has the advantages of: i) requiring only one cryptosystem; ii) not leaking the relative order of fresh feature samples; iii) being able to deal with any type of features (numerical or non-numerical). Keywords: Privacy-preserving implicit authentication, privacy-preserving set intersection, implicit authentication, active authentication, transparent authentication, risk mitigation, data brokers.Comment: IFIP SEC 2015-Intl. Information Security and Privacy Conference, May 26-28, 2015, IFIP AICT, Springer, to appea

Developing a Tool for Evaluating Ageism in Nursing Care of Older People in Kashan/Iran

Ageism implies negative views and attitudes towards older people. These unconscious behaviors could make the elderly feel as if they were no longer useful for the family and community. Ageism is common in healthcare services. The objective of this study was to develop a tool to assess ageism in nursing care in Kashan/Iran 2015. This psychometric study was carried out in four stages: literature review for item generation; content validity testing; exploratory factor analysis (EFA) for evaluation of construct validity; and reliability assessment. The data analyzed with SPSS version 16. The final questionnaire had 24 items. The total CVI and CVR were 0.88 and 0.57. Explanatory factor analysis identified 3 factors of respecting older adult in nursing care (14 items); age discrimination and negative views towards older adults (5 items); attention to older adult and their basic caring needs (5 items). The three factors could explain 49.54 of variance. The test-re-test correlation stood at 0.9. The internal consistency of the questionnaire was Cronbach�s alpha =0.85. A valid and reliable instrument for the evaluation of ageism in nursing care was developed in this study. © 2019, Springer Science+Business Media, LLC, part of Springer Nature

Elevation of cyclic AMP causes an imbalance between NF-κB and p53 in NALM-6 cells treated by doxorubicin

We previously showed that cAMP can inhibit DNA damage-induced wild type p53 accumulation in human pre-B NALM-6 cells, leading to a profound reduction of their apoptotic response. Here, we provide evidence for the potentiation of DNA damage-induced NF-κB activation by cAMP. We found that inhibition of NF-κB activation prevents the inhibitory effect of cAMP on doxorubicin-induced apoptosis. Moreover, cAMP exerts its inhibitory effect on doxorubicin-induced apoptosis in a PKA-independent manner. The present study also shows that elevation of cAMP prolongs the phosphorylation of IκB and subsequent activation of NF-κB in doxorubicin treated NALM-6 cells in a proteasome-dependent manner. Taken together, our results demonstrate that cAMP abrogates the balance between apoptotic and antiapoptotic transcription factors that are hallmarks of DNA damage signaling. © 2010 Federation of European Biochemical Societies

Socio-Economic Factors Affecting the Income of Small-scale Agroforestry Farms in Hill Country Areas in Yemen: A comparison of OLS and WLS Determinants

Yemen is a less-developed country in the Arabian Peninsula, with only 3% arable land. An agroforestry land-use system has been practiced traditionally by small-scale farmers, but is associated with low productivity and income. A study has been undertaken to determine the socio-economic attributes of farmers that influence the financial performance of agroforestry and nonagroforestry farms in the Bura’a Mountain region. A survey was conducted of 150 farmers involved in both agroforestry and non-agroforestry. Both OLS and WLS regression were applied, and coefficients compared in terms of consistency and goodness of fit. Incomes of farmers were found to be influenced by education, area of land, livestock holding, family size, and whether coffee is grown, but not farmer’s age. The WLS method produced efficient and consistent results, whereas OLS regression was affected by the heteroscedasticity. The findings of the study indicate that the farmers of the study area are in need of financial and technical support from government to increase their income. Infrastructural development and public intervention in developing farmers’ technical know-how could enhance production and ensure the optimum use of land as well as soil and water conservation

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells

Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP). Searching for the most clinically relevant approaches for treating colorectal metastatic disease by isolated hepatic perfusion (IHP), we developed the application of oxaliplatin concomitantly with hyperthermia and humanized death receptor 4 (DR4) antibody mapatumumab (Mapa), and investigated the molecular mechanisms of this multimodality treatment in human colon cancer cell lines CX-1 and HCT116 as well as human colon cancer stem cells Tu-12, Tu-21 and Tu-22. We showed here, in this study, that the synergistic effect of the multimodality treatment-induced apoptosis was caspase dependent and activated death signaling via both the extrinsic apoptotic pathway and the intrinsic pathway. Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. The downregulation of cellular FLICE inhibitory protein long isoform (c-FLIPL) in the extrinsic pathway was accomplished through ubiquitination at lysine residue (K) 195 and protein synthesis inhibition. Overexpression of c-FLIPL mutant (K195R) and Bcl-xL mutant (S62A) completely abrogated the synergistic effect. The successful outcome of this study supports the application of multimodality strategy to patients with colorectal hepatic metastases who fail to respond to standard chemoradiotherapy that predominantly targets the mitochondrial apoptotic pathway. © 2013 Song et al

Boundary Conditions for Elastohydrodynamics of Circular Point Contacts

The paper presents the solution of an elastohydrodynamic point contact condition using inlet and outlet lubricant entrainment with partial counter-flow. The inlet and outlet boundaries are determined using potential flow analysis for the pure rolling of contiguous surfaces. This shows that Swift–Stieber boundary conditions best conform to the observed partial counter-flow at the inlet conjunction, satisfying the compatibility condition. For the outlet region, the same is true when Prandtl–Hopkins boundary conditions are employed. Using these boundary conditions, the predictions conform closely to the measured pressure distribution using a deposited pressure-sensitive micro-transducer in a ball-to-flat race contact. Furthermore, the predicted conjunctional shape closely conforms to the often observed characteristic keyhole conjunction through optical interferometry. The combined numerical–experimental analysis with realistic boundary conditions described here has not hitherto been reported in the literature