Stammzellbasierte Ansätze zur Therapie von Innenohrerkrankungen

Zusammenfassung: Das große Potenzial von Stammzellen zur Regeneration verlorener Gewebezellen wird zunehmend in allen Fachbereichen der modernen Medizin erkannt. Abgesehen von Blutstammzellen haben Stammzellen aber noch nicht Einzug in klinische Therapieformen gehalten. Die heutigen Experimente mit Stammzellen für die Therapie von Innenohrerkrankungen sind im Bereich der Grundlagenforschung anzusiedeln. Mehrere vielversprechende Arbeiten haben bewiesen, dass morphologisch und immunologisch differenzierbare Innenohrzellen wie Haarzellen, Stützzellen und auditorische Nervenzellen, in vitro und in vivo aus verschiedenen Stammzelltypen generiert werden können. Bisher haben aber noch keine Studien funktionelle Resultate in Bezug auf das Hörvermögen oder die vestibuläre Funktion geliefer

An Innovative Approach to Achieve Compositionality Efficiently using Multi-Version Object Based Transactional Systems

In the modern era of multicore processors, utilizing cores is a tedious job. Synchronization and communication among processors involve high cost. Software transaction memory systems (STMs) addresses this issues and provide better concurrency in which programmer need not have to worry about consistency issues. Another advantage of STMs is that they facilitate compositionality of concurrent programs with great ease. Different concurrent operations that need to be composed to form a single atomic unit is achieved by encapsulating them in a single transaction. In this paper, we introduce a new STM system as multi-version object based STM (MVOSTM) which is the combination of both of these ideas for harnessing greater concurrency in STMs. As the name suggests MVOSTM, works on a higher level and maintains multiple versions corresponding to each key. We have developed MVOSTM with the unlimited number of versions corresponding to each key. In addition to that, we have developed garbage collection for MVOSTM (MVOSTM-GC) to delete unwanted versions corresponding to the keys to reduce traversal overhead. MVOSTM provides greater concurrency while reducing the number of aborts and it ensures compositionality by making the transactions atomic. Here, we have used MVOSTM for the list and hash-table data structure as list-MVOSTM and HT- MVOSTM. Experimental results of list-MVOSTM outperform almost two to twenty fold speedup than existing state-of-the-art list based STMs (Trans-list, Boosting-list, NOrec-list, list-MVTO, and list-OSTM). HT-MVOSTM shows a significant performance gain of almost two to nineteen times better than existing state-of-the-art hash-table based STMs (ESTM, RWSTMs, HT-MVTO, and HT-OSTM). MVOSTM with list and hash-table shows the least number of aborts among all the existing STM algorithms. MVOSTM satisfies correctness-criteria as opacity.Comment: 35 pages, 23 figure

Black brane entropy and hydrodynamics: the boost-invariant case

The framework of slowly evolving horizons is generalized to the case of black branes in asymptotically anti-de Sitter spaces in arbitrary dimensions. The results are used to analyze the behavior of both event and apparent horizons in the gravity dual to boost-invariant flow. These considerations are motivated by the fact that at second order in the gradient expansion the hydrodynamic entropy current in the dual Yang-Mills theory appears to contain an ambiguity. This ambiguity, in the case of boost-invariant flow, is linked with a similar freedom on the gravity side. This leads to a phenomenological definition of the entropy of black branes. Some insights on fluid/gravity duality and the definition of entropy in a time-dependent setting are elucidated.Comment: RevTeX, 42 pages, 4 figure

Inventory of forest and rangeland resources, including forest stress

There are no author-identified significant results in this report

Inventory of forest and rangeland resources, including forest stress

There are no author-identified significant results in this report

Inventory of forest and rangeland resources, including forest stress

There are no author-identified significant results in this report

Inventory of forest and rangeland resources, including forest stress

There are no author-identified significant results in this report

Localization of Eigenfunctions in the Stadium Billiard

We present a systematic survey of scarring and symmetry effects in the stadium billiard. The localization of individual eigenfunctions in Husimi phase space is studied first, and it is demonstrated that on average there is more localization than can be accounted for on the basis of random-matrix theory, even after removal of bouncing-ball states and visible scars. A major point of the paper is that symmetry considerations, including parity and time-reversal symmetries, enter to influence the total amount of localization. The properties of the local density of states spectrum are also investigated, as a function of phase space location. Aside from the bouncing-ball region of phase space, excess localization of the spectrum is found on short periodic orbits and along certain symmetry-related lines; the origin of all these sources of localization is discussed quantitatively and comparison is made with analytical predictions. Scarring is observed to be present in all the energy ranges considered. In light of these results the excess localization in individual eigenstates is interpreted as being primarily due to symmetry effects; another source of excess localization, scarring by multiple unstable periodic orbits, is smaller by a factor of $\sqrt{\hbar}$.Comment: 31 pages, including 10 figure

Inventory of forest and rangeland and detection of forest stress

The author has identified the following significant results. Eucalyptus tree stands killed by low temperatures in December 1972 were outlined by image enhancement of two separate dates of ERTS-1 images (January 22, 1973-I.D. 1183-18175 and April 22, 1973-I.D. 1273-18183). Three stands larger than 500 meters in size were detected very accurately. In Colorado, range and grassland communities were analyzed by visual interpretation of color composite scene I.D. 1028-17135. It was found that mixtures of plant litter, amount and kind of bare soil, and plant foliage cover made classification of grasslands very difficult. Changes in forest land use were detected on areas as small as 5 acres when ERTS-1 color composite scene 1264-15445 (April 13, 1973) was compared with 1966 ASCS index mosaics (scale 1:60,000). Verification of the changes were made from RB-57 underflight CIR transparencies (scale 1:120,000)