Massive Dualities in Six Dimensions

We study compactifications of string theory and M-theory to six dimensions with background fluxes. The nonzero fluxes lead to additional mass parameters. We derive the S- and T-duality rules for the corresponding (massive) supergravity theories. Specifically, we investigate the massive T-duality between Type IIA superstring theory compactified on K3 with background fluxes and Type IIB superstring theory compactified on K3. Furthermore, we generalise to the massive case the 6D 'string-string' S-duality between M-theory on K3 x S^1 and the Heterotic String on T^4. Whereas in the case of massive T--duality the mass parameters are in the fundamental representation of the U-duality group O(4,20) we find that in the case of massive S-duality they are in the 3-index antisymmetric representation. In the latter case the mass parameters involved extend those of Kaloper and Myers. We apply our duality rules to massive brane solutions, like the domain wall solutions corresponding to the mass parameters and find new massive brane solutions. Finally, we discuss the higher-dimensional interpretation of the dualities and brane solutions.Comment: 28 page

Geometry of all supersymmetric type I backgrounds

We find the geometry of all supersymmetric type I backgrounds by solving the gravitino and dilatino Killing spinor equations, using the spinorial geometry technique, in all cases. The solutions of the gravitino Killing spinor equation are characterized by their isotropy group in Spin(9,1), while the solutions of the dilatino Killing spinor equation are characterized by their isotropy group in the subgroup Sigma(P) of Spin(9,1) which preserves the space of parallel spinors P. Given a solution of the gravitino Killing spinor equation with L parallel spinors, L = 1,2,3,4,5,6,8, the dilatino Killing spinor equation allows for solutions with N supersymmetries for any 0 < N =< L. Moreover for L = 16, we confirm that N = 8,10,12,14,16. We find that in most cases the Bianchi identities and the field equations of type I backgrounds imply a further reduction of the holonomy of the supercovariant connection. In addition, we show that in some cases if the holonomy group of the supercovariant connection is precisely the isotropy group of the parallel spinors, then all parallel spinors are Killing and so there are no backgrounds with N < L supersymmetries.Comment: 73 pages. v2: minor changes, references adde

Revealing causal heterogeneity using time series analysis of ambulatory assessments: application to the association between depression and physical activity after myocardial infarction

Objective: Studies in psychosomatic medicine are characterized by analyses that typically compare groups. This nomothetic approach leads to conclusions that apply to the average group member but not necessarily to individual patients. Idiographic studies start at the individual patient and are suitable to study associations that differ between time points or between individuals. We illustrate the advantages of the idiographic approach in analyzing ambulatory assessments, taking the association between depression and physical activity after myocardial infarction as an example. Methods: Five middle-aged men who had myocardial infarction with mild to moderate symptoms of depression were included in this study. Four of these. participants monitored their physical activity and depressive symptoms during a period of 2 to 3 months using a daily self-registration form. The time series of each individual participant were investigated using vector autoregressive modeling, which enables the analysis of temporal dynamics between physical activity and depression. Results: We found causal heterogeneity in the association between depression and physical activity. Participants differed in the predominant direction of effect, which was either from physical activity to depression (n = 1,85 observations, unstandardized effect size = -0.183, p=.03) or from depression to physical activity (n = 2, 65 and 59 observations, unstandardized effect sizes = -0.038 and -0.381, p<.001 and p=.04). Also, the persistency of effects differed among individuals. Conclusions: Vector autoregressive models are suitable in revealing causal heterogeneity and can be easily used to analyze ambulatory assessments. We suggest that these models might bridge the gap between science and clinical practice by translating epidemiological results to individual patients

Inflation by Alignment

Pseudo-Goldstone bosons (pGBs) can provide technically natural inflatons, as has been comparatively well-explored in the simplest axion examples. Although inflationary success requires trans-Planckian decay constants, f > Mp, several mechanisms have been proposed to obtain this, relying on (mis-)alignments between potential and kinetic energies in multiple-field models. We extend these mechanisms to a broader class of inflationary models, including in particular the exponential potentials that arise for pGB potentials based on noncompact groups (and so which might apply to moduli in an extra-dimensional setting). The resulting potentials provide natural large-field inflationary models and can predict a larger primordial tensor signal than is true for simpler single-field versions of these models. In so doing we provide a unified treatment of several alignment mechanisms, showing how each emerges as a limit of the more general setup.Comment: Several references added in update. 7 pages, 4 figure

Reduction of Coxiella burnetii prevalence by vaccination of goats and sheep, the Netherlands

Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled. We identified the effect of vaccination on bacterial shedding by small ruminants. On the day of culling, samples of uterine fluid, vaginal mucus, and milk were obtained from 957 pregnant animals in 13 herds. Prevalence and bacterial load were reduced in vaccinated animals compared with unvaccinated animals. These effects were most pronounced in animals during their first pregnancy. Results indicate that vaccination may reduce bacterial load in the environment and human exposure to C. burnetii

Classical resolution of singularities in dilaton cosmologies

For models of dilaton-gravity with a possible exponential potential, such as the tensor-scalar sector of IIA supergravity, we show how cosmological solutions correspond to trajectories in a 2D Milne space (parametrized by the dilaton and the scale factor). Cosmological singularities correspond to points at which a trajectory meets the Milne horizon, but the trajectories can be smoothly continued through the horizon to an instanton solution of the Euclidean theory. We find some exact cosmology/instanton solutions that lift to black holes in one higher dimension. For one such solution, the singularities of a big crunch to big bang transition mediated by an instanton phase lift to the black hole and cosmological horizons of de Sitter Schwarzschild spacetimes.Comment: 24 pages, 2 figure

Cosmological D-instantons and Cyclic Universes

For models of gravity coupled to hyperbolic sigma models, such as the metric-scalar sector of IIB supergravity, we show how smooth trajectories in the `augmented target space' connect FLRW cosmologies to non-extremal D-instantons through a cosmological singularity. In particular, we find closed cyclic universes that undergo an endless sequence of big-bang to big-crunch cycles separated by instanton `phases'. We also find `big-bounce' universes in which a collapsing closed universe bounces off its cosmological singularity to become an open expanding universe.Comment: 21 pages, 4 figures. v2: minor change

Cross-Comparison of Climate Change adaptation Strategies Across Large River Basins in Europe, Africa and Asia

A cross-comparison of climate change adaptation strategies across regions was performed, considering six large river basins as case study areas. Three of the basins, namely the Elbe, Guadiana, and Rhine, are located in Europe, the Nile Equatorial Lakes region and the Orange basin are in Africa, and the Amudarya basin is in Central Asia. The evaluation was based mainly on the opinions of policy makers and water management experts in the river basins. The adaptation strategies were evaluated considering the following issues: expected climate change, expected climate change impacts, drivers for development of adaptation strategy, barriers for adaptation, state of the implementation of a range of water management measures, and status of adaptation strategy implementation. The analysis of responses and cross-comparison were performed with rating the responses where possible. According to the expert opinions, there is an understanding in all six regions that climate change is happening. Different climate change impacts are expected in the basins, whereas decreasing annual water availability, and increasing frequency and intensity of droughts (and to a lesser extent floods) are expected in all of them. According to the responses, the two most important drivers for development of adaptation strategy are: climate-related disasters, and national and international policies. The following most important barriers for adaptation to climate change were identified by responders: spatial and temporal uncertainties in climate projections, lack of adequate financial resources, and lack of horizontal cooperation. The evaluated water resources management measures are on a relatively high level in the Elbe and Rhine basins, followed by the Orange and Guadiana. It is lower in the Amudarya basin, and the lowest in the NEL region, where many measures are only at the planning stage. Regarding the level of adaptation strategy implementation, it can be concluded that the adaptation to climate change has started in all basins, but progresses rather slowl