O emprego de colheitadeiras automotrizes na colheita de sementes de plantas forrageiras tropicais.

O uso da colheitadeira automotriz em plantas forrageiras; Manejo de plantas forrageiras para produção de sementes e o uso de colheitadeira automotriz; Adaptações e regulagens em colheitadeiras automotrizes.bitstream/item/138241/1/CIRCULAR-TECNICA-06.pdfCNPG

O emprego de colheitadeiras automotrizes na colheita de sementes de plantas forrageiras tropicais.

O uso da colheitadeira automotriz em plantas forrageiras; Manejo de plantas forrageiras para produção de sementes e o uso de colheitadeira automotriz; Adaptações e regulagens em colheitadeiras automotrizes.bitstream/item/104608/1/Emprego-de-colheitadeiras-automotrizes.pd

A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin

Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect of selenium supplementation on the risk of type-2 diabetes in a population of relatively low selenium status as part of the UK PRECISE (PREvention of Cancer by Intervention with SElenium) pilot study. Plasma adiponectin concentration, a recognised independent predictor of type-2 diabetes risk and known to be correlated with circulating selenoprotein P, was the biomarker chosen. Methods: In a randomized, double-blind, placebo-controlled trial, five hundred and one elderly volunteers were randomly assigned to a six-month intervention with 100, 200 or 300 μg selenium/d as high-selenium or placebo yeast. Adiponectin concentration was measured by ELISA at baseline and after six months of treatment in 473 participants with one or both plasma samples available. Results: Mean (SD) plasma selenium concentration was 88.5 ng/g (19.1) at baseline and increased significantly in the selenium-treatment groups. In baseline cross-sectional analyses, the fully adjusted geometric mean of plasma adiponectin was 14% lower (95% CI, 0-27%) in the highest than in the lowest quartile of plasma selenium (P for linear trend = 0.04). In analyses across randomized groups, however, selenium supplementation had no effect on adiponectin levels after six months of treatment (P = 0.96). Conclusions: These findings are reassuring as they did not show a diabetogenic effect of a six-month supplementation with selenium in this sample of elderly individuals of relatively low selenium status

The Dynamical Environment of Dawn at Vesta

Dawn is the first NASA mission to operate in the vicinity of the two most massive asteroids in the main belt, Ceres and Vesta. This double-rendezvous mission is enabled by the use of low-thrust solar electric propulsion. Dawn will arrive at Vesta in 2011 and will operate in its vicinity for approximately one year. Vesta's mass and non-spherical shape, coupled with its rotational period, presents very interesting challenges to a spacecraft that depends principally upon low-thrust propulsion for trajectory-changing maneuvers. The details of Vesta's high-order gravitational terms will not be determined until after Dawn's arrival at Vesta, but it is clear that their effect on Dawn operations creates the most complex operational environment for a NASA mission to date. Gravitational perturbations give rise to oscillations in Dawn's orbital radius, and it is found that trapping of the spacecraft is possible near the 1:1 resonance between Dawn's orbital period and Vesta's rotational period, located approximately between 520 and 580 km orbital radius.This resonant trapping can be escaped by thrusting at the appropriate orbital phase. Having passed through the 1:1 resonance, gravitational perturbations ultimately limit the minimum radius for low-altitude operations to about 400 km,in order to safely prevent surface impact. The lowest practical orbit is desirable in order to maximize signal-to-noise and spatial resolution of the Gamma-Ray and Neutron Detector and to provide the highest spatial resolution observations by Dawn's Framing Camera and Visible InfraRed mapping spectrometer. Dawn dynamical behavior is modeled in the context of a wide range of Vesta gravity models. Many of these models are distinguishable during Dawn's High Altitude Mapping Orbit and the remainder are resolved during Dawn's Low Altitude Mapping Orbit, providing insight into Vesta's interior structure.Comment: Corrected normalization coefficients; updated table text and reference

High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism

The essential trace element selenium has long been considered to exhibit anti-diabetic and insulin-mimetic properties, but recent epidemiological studies indicated supranutritional selenium intake and high plasma selenium levels as possible risk factors for development of type 2 diabetes, pointing to adverse effects of selenium on carbohydrate metabolism in humans. However, increased plasma selenium levels might be both a consequence and a cause of diabetes. We summarize current evidence for an interference of selenium compounds with insulin-regulated molecular pathways, most notably the phosphoinositide-3-kinase/protein kinase B signaling cascade, which may underlie some of the pro- and anti-diabetic actions of selenium. Furthermore, we discuss reports of hyperinsulinemia, hyperglycemia and insulin resistance in mice overexpressing the selenoenzyme glutathione peroxidase 1. The peroxisomal proliferator-activated receptor gamma coactivator 1α represents a key regulator for biosynthesis of the physiological selenium transporter, selenoprotein P, as well as for hepatic gluconeogenesis. As proliferator-activated receptor gamma coactivator 1α has been shown to be up-regulated in livers of diabetic animals and to promote insulin resistance, we hypothesize that dysregulated pathways in carbohydrate metabolism and a disturbance of selenium homeostasis are linked via proliferator-activated receptor gamma coactivator 1α

Boosting and lassoing new prostate cancer SNP risk factors and their connection to selenium

We begin by arguing that the often used algorithm for the discovery and use of disease risk factors, stepwise logistic regression, is unstable. We then argue that there are other algorithms available that are much more stable and reliable (e.g. the lasso and gradient boosting). We then propose a protocol for the discovery and use of risk factors using lasso or boosting variable selection. We then illustrate the use of the protocol with a set of prostate cancer data and show that it recovers known risk factors. Finally, we use the protocol to identify new and important SNP based risk factors for prostate cancer and further seek evidence for or against the hypothesis of an anticancer function for Selenium in prostate cancer. We find that the anticancer effect may depend on the SNP-SNP interaction and, in particular, which alleles are present