Cervical chondroid chordoma in a standard dachshund: a case report

A ten-year-old male standard dachshund was presented with a history of neck pain and progressive gait disturbances. Following a neurological examination and diagnostic imaging, including CT, a neoplastic lesion involving the third and fourth cervical vertebrae was suspected. The lesion included an extradural mass on the right side of the spinal canal causing a local compression of the cervical cord. Surgery, using a modified dorsal laminectomy procedure, was performed in order to decompress the cervical spinal cord. Histopathological examination of the extradural mass indicated that the tumour was a chondroid chordoma. Following discharge, the quality of life for the dog was very good for a sustained period, but clinical signs recurred at 22 months. The dog was euthanased 25 months post-surgery. On post-mortem examination, a regrowth of neoplastic tissue was found to have infiltrated the bone and spinal cord at C3-C4. This is the first report to show that palliative surgery can offer successful long-lasting treatment of chondroid chordoma of the cervical spine in the dog

Rapid data access: Key to integrated use of environmental characterization and monitoring information

Environmental investigations result in large quantities of data. The value of these data lies in their interpretation and use by project staff, management, and the regulatory community. Traditional modes of data access can be frustrating and time-consuming. Software tools that join networking technology of the World Wide Web with database access have decreased labor-intensive overhead in site characterization and monitoring, thus increasing the efficiency of the ground water restoration project at Lawrence Livermore National Laboratory

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi

Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for the stability of the triple helix. C-P4Hs are most often oligomeric complexes, with enzymatic activity contributed by the α subunits, and the β subunits formed by protein disulfide isomerase (PDI). Here we characterise this enzyme class in the important human parasitic nematode Brugia malayi. All potential C-P4H subunits were identified by detailed bioinformatic analysis of sequence databases, function was investigated both by RNAi in the parasite and heterologous expression in Caenorhabditis elegans, while biochemical activity and complex formation were examined via co-expression in insect cells. Simultaneous RNAi of two B. malayi C-P4H α subunit-like genes resulted in a striking, highly penetrant body morphology phenotype in parasite larvae. This was replicated by single RNAi of a B. malayi C-P4H β subunit-like PDI. Surprisingly however, the B. malayi proteins were not capable of rescuing a C. elegans α subunit mutant, whereas the human enzymes could. In contrast, the B. malayi PDI did functionally complement the lethal phenotype of a C. elegans β subunit mutant. Comparison of recombinant and parasite derived material indicates that enzymatic activity may be dependent on a non-reducible, inter-subunit cross-link, present only in the parasite. We therefore demonstrate that C-P4H activity is essential for development of B. malayi and uncover a novel parasite-specific feature of these collagen biosynthetic enzymes that may be exploited in future parasite control

Effect of virtual reality training on laparoscopic surgery: randomised controlled trial

Objective To assess the effect of virtual reality training on an actual laparoscopic operation

A persistent Norwegian Atlantic Current through the Pleistocene glacials

Changes in ocean‐circulation regimes in the northern North Atlantic and the Nordic Seas may affect not only the Arctic but potentially hemispheric or even global climate. Therefore, unraveling the long‐term evolution of the North Atlantic Current‐Norwegian Atlantic Current system through the Pleistocene glaciations could yield useful information and climatological context for understanding contemporary changes. In this work, ~50,000 km2 of 3‐D seismic reflection data are used to investigate the Pleistocene stratigraphy for evidence of paleo‐oceanographic regimes on the mid‐Norwegian margin since 2.58 Ma. Across 33 semicontinuous regional paleo‐seafloor surfaces ~17,500 iceberg scours have been mapped. This mapping greatly expands our spatiotemporal understanding of currents and iceberg presence in the eastern Nordic Seas. The scours display a dominant southwest‐northeast trend that complements previous sedimentological and numerical modeling studies that suggest northward‐flowing currents in the Norwegian Sea during the Pleistocene. This paleo‐oceanographic study suggests that through many of the Pleistocene glaciations, the location of surface ocean currents in the Norwegian Sea and, by extension, the eastern North Atlantic, were broadly similar to the present

Modeling Operating Speed and Deceleration on Two-Lane Rural Roads with Global Positioning System Data

[EN] In the road design process, speed variation along the road segment is an important issue to consider in adapting road geometry to drivers' expectations. To achieve this objective, speed criteria are used to evaluate road consistency. Being able to estimate the operating speed in the design phase can lead to safer road alignment. With this objective, several researchers have developed operating speed models. Most of these models are based on collected spot speed data. They assume constant speed on curves and, therefore, deceleration that occurs entirely on the approach tangent. According to these assumptions, spot speed data are collected at the center of the horizontal curve and at the midpoint of the preceding tangent to obtain operating speed models. This paper presents a new methodology based on the use of Global Positioning System devices that allow continuous collecting and processing of speed data. With this new methodology, not only can new and more accurate operating speed models he developed, but cited hypotheses can also be checked. Observed speed continuous profiles allow studies that previously could not be done, especially as related to deceleration and speed variations. This study calibrated new speed models, including three for horizontal curves with a radius curve and the curvature change rate of a single curve as explanatory variables, and one for tangents that incorporates the curve speed model. Tangent-curve speed variations are evaluated, with comparison of Delta(85)V and Delta V(85), analysis of the deceleration length occurring on a curve, and development of two deceleration models.The authors thank the Center for Studies and Experimentation of Public Works of the Spanish Ministry of Public Works, which partially subsidized the research. The authors also thank the Infrastructure and Transportation Department, General Directorate of Public Works, Valencian Government, Spain; the Valencian Provincial Council; and the Ministry of the Interior, General Directorate of Traffic, Spain, for their cooperation in field data gathering.Pérez Zuriaga, AM.; García García, A.; Camacho-Torregrosa, FJ.; D'attoma, P. (2010). Modeling Operating Speed and Deceleration on Two-Lane Rural Roads with Global Positioning System Data. Transportation Research Record. 2171:11-20. doi:10.3141/2171-02S1120217

Centralised and Distributed Optimization for Aggregated Flexibility Services Provision

The recent deployment of distributed battery units in prosumer premises offer new opportunities for providing aggregated flexibility services to both distribution system operators and balance responsible parties. The optimization problem presented in this paper is formulated with an objective of cost minimization which includes energy and battery degradation cost to provide flexibility services. A decomposed solution approach with the alternating direction method of multipliers (ADMM) is used instead of commonly adopted centralised optimization to reduce the computational burden and time, and then reduce scalability limitations. In this work we apply a modified version of ADMM that includes two new features with respect to the original algorithm: first, the primal variables are updated concurrently, which reduces significantly the computational cost when we have a large number of involved prosumers; second, it includes a regularization term named Proximal Jacobian (PJ) that ensures the stability of the solution. A case study is presented for optimal battery operation of 100 prosumer sites with real-life data. The proposed method finds a solution which is equivalent to the centralised optimization problem and is computed between 5 and 12 times faster. Thus, aggregators or large-scale energy communities can use this scalable algorithm to provide flexibility services.Comment: 10 pages, 7 figure

Reduction in acute filariasis morbidity during a mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea.

Background Acute painful swelling of the extremities and scrotum are debilitating clinical manifestations of Wuchereria bancrofti infection. The ongoing global program to eliminate filariasis using mass drug administration is expected to decrease this and other forms of filarial morbidity in the future by preventing establishment of new infections as a consequence of eliminating transmission by the mosquito vector. We examined whether mass treatment with anti-filarial drugs has a more immediate health benefit by monitoring acute filariasis morbidity in Papua New Guinean communities that participated in a 5-year mass drug administration trial. Methodology/Principal Findings Weekly active surveillance for acute filariasis morbidity defined by painful swelling of the extremities, scrotum and breast was performed 1 year before and each year after 4 annual mass administrations of anti-filarial drugs (16,480 person-years of observation). Acute morbidity events lasted <3 weeks in 92% of affected individuals and primarily involved the leg (74–79% of all annual events). The incidence for all communities considered together decreased from 0.39 per person-year in the pre-treatment year to 0.31, 0.15, 0.19 and 0.20 after each of 4 annual treatments (p<0.0001). Residents of communities with high pre-treatment transmission intensities (224–742 infective bites/person/year) experienced a greater reduction in acute morbidity (0.62 episodes per person-year pre-treatment vs. 0.30 in the 4th post-treatment year) than residents of communities with moderate pre-treatment transmission intensities (24–167 infective bites/person/year; 0.28 episodes per person-year pre-treatment vs. 0.16 in the 4th post-treatment year). Conclusions Mass administration of anti-filarial drugs results in immediate health benefit by decreasing the incidence of acute attacks of leg and arm swelling in people with pre-existing infection. Reduction in acute filariasis morbidity parallels decreased transmission intensity, suggesting that continuing exposure to infective mosquitoes is involved in the pathogenesis of acute filariasis morbidity