Some New Theorems Analogous to Green's

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State and Local Government

Covers cases on municipal corporations—labor unions—right of municipal employees to strike—governmental and proprietary functions (Lehne); on the incorporation of municipalities—delegation of legislative powers (Colgrove); on the legislative power of first-class cities—use of parking meters for private advertising purposes upheld (Nutting); and on eminent domain—market value—valuation of mineral deposits (Colgrove)

Pioneers in Education: A History of Framingham State College (1989 edition)

Created in honor of the 150th anniversary of the founding of Framingham State University.http://digitalcommons.framingham.edu/pioneers/1000/thumbnail.jp

Exile Vol. XLIII No. 1

41st Year Title Page 1 Epigraph by Ezra Pound 2 Table of Contents 3 Shame(d) by alex e. blazer 4 enter play by alex e. blazer 5 sunday\u27s sex ed fundamentals by alex e. blazer 6 Dancing, Dedicated to Shannon by Paul Genesius Durica 7-8 On the Rocks by Katie Keller 9-10 In Heritage Station, Huntington, WV by Trish Klei 11 Untitled by Tyler Smith 12-14 Untitled by Camille Gammon-Hittelman 15 Untitled by erika laine hansen 16 Androgynous Implications by Elizabeth Nutting 17 Patterns of the Clouds by Angela Rae Bliss 18 Sister, Sister, Aspirations by Elizabeth Nutting 19 Sick Girl by Helena Jasna Oroz 20-21 The Television Era by Trish Klei 22 I\u27m Mistaken; He\u27s Alive by Bekah Taylor 23 Crucifixion on the Corner of State and Bruening by Paul Genesius Durica 24-25 reLiAnce: CorKscrews by Bekah Taylor 26 Colors of the Beast by Helena Jasna Oroz 27 Development by Brian P. Voroselo 28-31 Untitled by Peter Rees 32 Public Bathhouse by Paul Genesius Durica 33 The Sound of Silence Upon the Onyx Wall of Memories by Angela Rae Bliss 34 Untitled by Peter Rees 35 Empress by Paul Genesius Durica 36-37 Life is what you make it by Cathy Graham 38-42 Untitled by Peter Rees 43 Competition by Bekah Taylor 44 changeling by Casey McArdle 45 A Kiss is Just a Kiss, A Lick is Just a Lick by Helena Jasna Oroz 46 the-r-apist by alex e. blazer 47 Gone by Latisha Newton 48 Sonnet by Touch by Trish Klei 49 Contributors\u27 Notes 49-51 Staff Page & Editorial Policy 52 Editorial decisions are shared equally among the editorial board. Submissions are judged on a name-blind basis. Members of boards whose own work is under consideration must abstain from discussion regarding that work. -5

Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.

Introduction The aim of this study was to investigate if defective repair of DNA double-strand break (DSB) in head and neck squamous cell carcinoma (HNSCC) could be used as an early predictor of treatment response.Methods Tumour biopsy 24-36 h following induction chemotherapy (IC) and pre-treatment biopsies were stained for RAD51 and geminin (S-phase marker) for immunofluorescence in patients with HNSCC. The difference between RAD51 score (percentage of geminin-positive cells that were also positive for RAD51) was calculated for the two specimens. Tumours with a percentage difference of⩽10% were deemed to have repaired IC-induced DSBs, and were classified as 'RAD51 negative'. Response at 3 months post treatment and human papilloma virus (HPV) status were assessed.Results Thirteen pairs of samples were available for analyses. Three samples were classified as RAD51 negative and 10 as RAD51 positive at 24 h post IC. All of the three patients with tumours classified as RAD51 negative had partial response or progressive disease and the 10 patients with tumours deemed RAD51 positive had a complete response. 100% of the HPV-positive tumours were RAD51 positive and had a complete response.Conclusions We have demonstrated that impaired DSB DNA repair may underlie enhanced treatment sensitivity of HPV-positive HNSCC and repair capacity following platinum-induced DNA damage predicts response in HNSCC. This has potential as a biomarker for patient selection in trials of DNA damage response pathway modulation

Intensity modulated radiotherapy (IMRT) in patients with carcinomas of the paranasal sinuses: clinical benefit for complex shaped target volumes

INTRODUCTION: The aim of the study was to evaluate the clinical outcome of intensity modulated radiotherapy (IMRT) in 46 patients with paranasal sinus tumors with special respect to treatment-related toxicity. PATIENTS AND METHODS: We treated 46 patients with histologically proven tumors of the paranasal sinuses with IMRT. Histological classification included squamous cell carcinoma in 6, adenocarcinoma in 8, adenoidcystic carcinoma in 20 and melanoma in 8 patients, respectively. Six patients had been treated with RT during initial therapy after primary diagnosis, and IMRT was performed for the treatment of tumor progression as re-irradiation. RESULTS: Overall survival rates were 96% at 1 year, 90% at 3 years. Calculated from the initiation of IMRT as primary radiotherapy, survival rates at 1 and 3 years were 95% and 80%. In six patients IMRT was performed as re-irradiation, and survival rate calculated from re-irradiation was 63% at 1 year. Local control rates were 85% at 1, 81% at 2 and 49% at 3 years after primary RT and 50% at 1 year after re-irradiation. Distant metastases-free survival in patients treated with IMRT as primary RT was 83% after 1 and 64% after 3 years. For patients treated as primary irradiation with IMRT, the distant control rate was 83% at 1 year and 0% at 2 years. No severe radiation-induced side-effects could be observed. CONCLUSION: IMRT for tumors of the paranasal sinuses is associated with very good tumor control rates. Treatment-related acute and long-term toxicity can be minimized as compared to historical results with conventional RT

How can medical schools contribute to bringing about health equity?

The role of medical schools is in a process of change. The World Health Organization has declared that they can no longer be ivory towers whose primary focus is the production of specialist physicians and cutting edge laboratory research. They must also be socially accountable and direct their activities towards meeting the priority health concerns of the areas they serve. The agenda must be set in partnership with stakeholders including governments, health care organisations and the public.<p></p> The concept of social accountability has particular resonance for the Bar Ilan Faculty of Medicine in the Galilee, Israel’s newest medical school, which was established with a purpose of reducing health inequities in the Region. As a way of exploring and understanding the issues, discussions were held with international experts in the field who visited the Galilee. A symposium involving representatives from other medical schools in Israel was also held to extend the discourse. Deliberations that took place are reported here.<p></p> The meaning of social accountability was discussed, and how it could be achieved. Three forms of action were the principal foci – augmentation of the medical curriculum, direct action through community engagement and political advocacy. A platform was set for taking the social accountability agenda forward, with the hope that it will impact on health inequalities in Israel and contribute to discussions elsewhere

The breadth of primary care: a systematic literature review of its core dimensions

Background: Even though there is general agreement that primary care is the linchpin of effective health care delivery, to date no efforts have been made to systematically review the scientific evidence supporting this supposition. The aim of this study was to examine the breadth of primary care by identifying its core dimensions and to assess the evidence for their interrelations and their relevance to outcomes at (primary) health system level. Methods: A systematic review of the primary care literature was carried out, restricted to English language journals reporting original research or systematic reviews. Studies published between 2003 and July 2008 were searched in MEDLINE, Embase, Cochrane Library, CINAHL, King's Fund Database, IDEAS Database, and EconLit. Results: Eighty-five studies were identified. This review was able to provide insight in the complexity of primary care as a multidimensional system, by identifying ten core dimensions that constitute a primary care system. The structure of a primary care system consists of three dimensions: 1. governance; 2. economic conditions; and 3. workforce development. The primary care process is determined by four dimensions: 4. access; 5. continuity of care; 6. coordination of care; and 7. comprehensiveness of care. The outcome of a primary care system includes three dimensions: 8. quality of care; 9. efficiency care; and 10. equity in health. There is a considerable evidence base showing that primary care contributes through its dimensions to overall health system performance and health. Conclusions: A primary care system can be defined and approached as a multidimensional system contributing to overall health system performance and health