Critical raw materials and substitutes in the light of India's self-sufficiency

THE Secretaries Committee of the Ministries has been asked in October , 1965, by the Government of India to consider the situation that may arise as a result of any withdrawal of aid or any application of economic sanctions by the big powers, and to consider steps nec-essary to meet such extreme situation in view of the present emergency conditions in the country. A prelimi-nary assessment by the Committee is that the economy of the country can bear the strain easily for six months but special attention needs to be given in non-ferrous import

Hazards in the Manufacture of RDX and HMX

Manufacture of cyclotrimethylenetrinitramine (RDX) and cyclotetramethylenetetranitramine (HMX) by the modified Bachmann process involves the nitrolysis of hexamine in glacial acetic acid with a solution of ammonium nitratein nitric acid, in the presence of excess of acetic anhydride. Fire, explosion and toxic hazards during the manfacture of these explosives are reviewed and discussed

Genetic Characterization of the Influenza A Pandemic (H1N1) 2009 Virus Isolates from India

Background: The Influenza A pandemic H1N1 2009 (H1N1pdm) virus appeared in India in May 2009 and thereafter outbreaks with considerable morbidity and mortality have been reported from many parts of the country. Continuous monitoring of the genetic makeup of the virus is essential to understand its evolution within the country in relation to global diversification and to track the mutations that may affect the behavior of the virus. Methods: H1N1pdm viruses were isolated from both recovered and fatal cases representing major cities and sequenced. Phylogenetic analyses of six concatenated whole genomes and the hemagglutinin (HA) gene of seven more isolates from May-September 2009 was performed with reference to 685 whole genomes of global isolates available as of November 24, 2009. Molecular characterization of all the 8 segments was carried out for known pathogenic markers. Results: The first isolate of May 2009 belonged to clade 5. Although clade 7 was the dominant H1N1pdm lineage in India, both clades 6 and 7 were found to be co-circulating. The neuraminidase of all the Indian isolates possessed H275, the marker for sensitivity to the neuraminidase inhibitor Oseltamivir. Some of the mutations in HA are at or in the vicinity of antigenic sites and may therefore be of possible antigenic significance. Among these a D222G mutation in the HA receptor binding domain was found in two of the eight Indian isolates obtained from fatal cases. Conclusions: The majority of the 13 Indian isolates grouped in the globally most widely circulating H1N1pdm clade 7

The prevention and management of HIV and sexual and gender-based violence: Responding to the needs of survivors and those-at-risk

The Population Council seeks to understand the social, economic, political, and physical context of risks for sexual and gender-based violence and HIV. Among the top priorities of Council research are supporting and evaluating efforts to prevent violence and HIV, including creating safe spaces for adolescent girls, and working with men and boys to change gender norms within the community; and comprehensively responding to the needs of survivors (including those who are HIV-infected) by strengthening health systems and integrating services. The purpose of this guide is to provide practical guidance on the steps necessary to establish and strengthen sexual violence (SV) services within existing public health facilities, improve linkages to other sectors, and engage local communities around issues of sexual violence. It includes tips, resources, and tools that will help partners and stakeholders design, implement, and evaluate SV programs

Dissipative collisions in 16^{16}O + 27^{27}Al at Elab_{lab}=116 MeV

The inclusive energy distributions of fragments (3$\leq$Z$\leq$7) emitted in the reaction $^{16}$O + $^{27}$Al at $E_{lab} =$116 MeV have been measured in the angular range $\theta_{lab}$= 15$^\circ$ - 115$^\circ$. A non-linear optimisation procedure using multiple Gaussian distribution functions has been proposed to extract the fusion-fission and deep inelastic components of the fragment emission from the experimental data. The angular distributions of the fragments, thus obtained, from the deep inelastic component are found to fall off faster than those from the fusion-fission component, indicating shorter life times of the emitting di-nuclear systems. The life times of the intermediate di-nuclear configurations have been estimated using a diffractive Regge-pole model. The life times thus extracted ($\sim 1 - 5\times 10^{-22}$ Sec.) are found to decrease with the increase in the fragment charge. Optimum Q-values are also found to increase with increasing charge transfer i.e. with the decrease in fragment charge.Comment: 9 pages, 4 figures, 1 tabl

Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes

Type 1 diabetes is a proinflammatory state characterised by increased levels of circulating biomarkers of inflammation and monocyte activity. We have shown increased Toll-like receptor 2 (TLR2) and TLR4 expression and signalling in monocytes from type 1 diabetic patients. Several endogenous ligands of TLR2 and TLR4 have been identified; however, there is a paucity of data on levels of these endogenous ligands in diabetes. Thus, the aim of this study was to examine circulating levels of exogenous/endogenous ligands of TLR2 and TLR4 in type 1 diabetic patients and to compare these with the levels in matched healthy controls. Healthy controls (n = 37) and type 1 diabetic patients (n = 34) were recruited, and a fasting blood sample was obtained. Circulating levels of endotoxin, heat-shock protein 60 (Hsp60), high-mobility group box 1 (HMGB1) and growth arrest-specific 6 (GAS6) proteins were assessed by ELISA, and TLR2 and TLR4 expression was determined by flow cytometry. Levels of the classical TLR4 ligand, endotoxin, were significantly elevated in type 1 diabetic patients compared with those in matched controls. Hsp60 and HMGB1 concentrations were also significantly increased in the patients (p < 0.01 and p < 0.001, respectively). No significant differences were observed in GAS6. We report the novel observation that levels of ligands of TLR2 and TLR4 are significantly elevated in type 1 diabetes, and this, in concert with hyperglycaemia, accounts for the increase in TLR2 and TLR4 activity, underscoring the proinflammatory state of type 1 diabetes