Well-posedness for a model of individual clustering

25 pagesInternational audienceWe study the well-posedness of a model of individual clustering. Given p > N ≥ 1 and an initial condition in W 1,p (Ω), the local existence and uniqueness of a strong solution is proved. We next consider two specific reproduction rates and show global existence if N = 1, as well as, the convergence to steady states for one of these rates

Improving translation memory matching and retrieval using paraphrases

This is an accepted manuscript of an article published by Springer Nature in Machine Translation on 02/11/2016, available online: https://doi.org/10.1007/s10590-016-9180-0 The accepted version of the publication may differ from the final published version.Most of the current Translation Memory (TM) systems work on string level (character or word level) and lack semantic knowledge while matching. They use simple edit-distance calculated on surface-form or some variation on it (stem, lemma), which does not take into consideration any semantic aspects in matching. This paper presents a novel and efficient approach to incorporating semantic information in the form of paraphrasing in the edit-distance metric. The approach computes edit-distance while efficiently considering paraphrases using dynamic programming and greedy approximation. In addition to using automatic evaluation metrics like BLEU and METEOR, we have carried out an extensive human evaluation in which we measured post-editing time, keystrokes, HTER, HMETEOR, and carried out three rounds of subjective evaluations. Our results show that paraphrasing substantially improves TM matching and retrieval, resulting in translation performance increases when translators use paraphrase-enhanced TMs

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying obesity-induced IR in skeletal muscle remains controversial; reduced post-receptor signalling of the insulin receptor substrate 1 (IRS1) adaptor protein and downstream effectors such as protein kinase B (PKB) have previously been implicated. We examined expression and/or activation of a number of components of the insulin-signalling cascade in skeletal muscle of 22 healthy young men (with body mass index (BMI) range, 20–37 kg/m2). Whole body insulin sensitivity (M value) and body composition was determined by the hyperinsulinaemic (40 mU. min−1.m−2.), euglycaemic clamp and by dual energy X-ray absorptiometry (DEXA) respectively. Skeletal muscle (vastus lateralis) biopsies were taken before and after one hour of hyperinsulinaemia and the muscle insulin signalling proteins examined by western blot and immunoprecipitation assay. There was a strong inverse relationship between M-value and BMI. The most striking abnormality was significantly reduced insulin-induced activation of p42/44 MAP kinase, measured by specific assay, in the volunteers with poor insulin sensitivity. However, there was no relationship between individuals' BMI or M-value and protein expression/phosphorylation of IRS1, PKB, or p42/44 MAP kinase protein, under basal or hyperinsulinaemic conditions. In the few individuals with poor insulin sensitivity but preserved p42/44 MAP kinase activation, other signalling defects were evident. These findings implicate defective p42/44 MAP kinase signalling as a potential contributor to obesity-related IR in a non-diabetic population, although clearly multiple signalling defects underlie obesity associated IR

Theory of Current and Shot Noise Spectroscopy in Single-Molecular Quantum Dots with Phonon Mode

Using the Keldysh nonequilibrium Green function technique, we study the current and shot noise spectroscopy of a single molecular quantum dot coupled to a local phonon mode. It is found that in the presence of electron-phonon coupling, in addition to the resonant peak associated with the single level of the dot, satellite peaks with the separation set by the frequency of phonon mode appear in the differential conductance. In the ``single level'' resonant tunneling region, the differential shot noise power exhibit two split peaks. However, only single peaks show up in the ``phonon assisted'' resonant-tunneling region. An experimental setup to test these predictions is also proposed.Comment: 5 pages, 3 eps figures embedde

Measurement of the conductance of a hydrogen molecule

Recent years have shown steady progress in research towards molecular electronics [1,2], where molecules have been investigated as switches [3-5], diodes [6], and electronic mixers [7]. In much of the previous work a Scanning Tunnelling Microscope was employed to address an individual molecule. As this arrangement does not provide long-term stability, more recently metal-molecule-metal links have been made using break junction devices [8-10]. However, it has been difficult to establish unambiguously that a single molecule forms the contact [11]. Here, we show that a single H2 molecule can form a stable bridge between Pt electrodes. In contrast to results for other organic molecules, the bridge has a nearly perfect conductance of one quantum unit, carried by a single channel. The H2-bridge provides a simple test system and a fundamental step towards understanding transport properties of single-molecule devices.Comment: 6 pages, 4 figure