456 research outputs found
Apprenticeship migration to three pre-industrial English towns
Tudor and Stuart England was a mobile society. The generally
high levels of geographical mobility went hand in hand with various
degrees of social and occupational mobility. Some of the most
important movements were of people from the countryside to the town,
as they were significant as a transfer of resources and an agency
of social mobilitYJ their chronological and geographical flows
provide an index of both changing urban fortunes and of the levels
of spatial integration and economic development upon which these
changing fortunes were based. Amongst the types of rural-urban
migration, the movement of teenagers to a town to serve an
apprenticeship is a particularly valuable topic for study. The
training of labour is important in any society and in preindustrial
England output could only be raised in many industries
through a greater input of labour. The areas from which the
apprentices were drawn represent the scale of organisation, economic
social and spatial, current in sixteenth and seventeenth century England.
This gives an indication of the level of development of the country
as it underwent the transition from a society largely based on the
discrete daily and weekly contacts around the provincial central
places, through an increase in scale to a regional integration
based upon county towns, to a~hesive national system.
Three county towns were selected, Chester, Gloucester and
Shrewsbury, as they each had a good series of apprenticeship records;
they represented the foci characteristic of the regional scale of
integration and they were associated one with another along the
England-Wales border, thus forming a convenient spatial system. The
results of the study confirm the findings on mobility in sixteenth
and seventeenth century England. Most migrants moved over short
distances and a few made long journeys. The propensity to move
varied with the status of the apprentices' backgroundsJ generally
the higher the status the longer the distance moved. Many
apprentices trained in an occupation different to that of their
fathers and some of these represented a significant degree of social
mobility. Nevertheless, association within the s~me sub-group
was common, either based upon the same raw material or upon the
type of work undertaken. The three towns organised a regional
scale of integration around themselves, reinforcing their roles
as important suppliers of goods and services to their hinterlands,
the extent of which remained constant throughout the period studied
Substructure in the Andromeda Galaxy Globular Cluster System
In the most prominent current scenario of galaxy formation, galaxies form
hierarchically through the merger of smaller systems. Such mergers could leave
behind dynamical signatures which may linger long after the event. In
particular, the globular cluster system (GCS) of a merging satellite galaxy may
remain as a distinct sub-population within the GCS of a massive galaxy. Using
the latest available globular cluster velocities and metallicities, we present
the results of a search for grouping in the GCS of our nearest large spiral
galaxy neighbor, M31. A modified friends-of-friends algorithm is used to
identify a number of possible merger remnants in projected position, radial
velocity and [Fe/H] parameter space. Numerical simulations are used to check
that such merger remnants are indeed plausible over the timescales of interest.
The identification of stellar streams associated with these groups is required
in order to confirm that they represent merger remnants.Comment: 19 pages, 3 figures, accepted for publication in the Ap
Plerixafor plus granulocyte colony-stimulating factor for patients with non-Hodgkin lymphoma and multiple myeloma: Long-term follow-up report
Solar Wakes of Dark Matter Flows
We analyze the effect of the Sun's gravitational field on a flow of cold dark
matter (CDM) through the solar system in the limit where the velocity
dispersion of the flow vanishes. The exact density and velocity distributions
are derived in the case where the Sun is a point mass. The results are extended
to the more realistic case where the Sun has a finite size spherically
symmetric mass distribution. We find that regions of infinite density, called
caustics, appear. One such region is a line caustic on the axis of symmetry,
downstream from the Sun, where the flow trajectories cross. Another is a
cone-shaped caustic surface near the trajectories of maximum scattering angle.
The trajectories forming the conical caustic pass through the Sun's interior
and probe the solar mass distribution, raising the possibility that the solar
mass distribution may some day be measured by a dark matter detector on Earth.
We generalize our results to the case of flows with continuous velocity
distributions, such as that predicted by the isothermal model of the Milky Way
halo.Comment: 30 pages, 8 figure
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling. Only a single hypomorphic mutation of ATR has been identified in this genetically heterogeneous condition. We now report that mutations in the gene encoding pericentrin (PCNT)--resulting in the loss of pericentrin from the centrosome, where it has key functions anchoring both structural and regulatory proteins--also cause Seckel syndrome. Furthermore, we find that cells of individuals with Seckel syndrome due to mutations in PCNT (PCNT-Seckel) have defects in ATR-dependent checkpoint signaling, providing the first evidence linking a structural centrosomal protein with DNA damage signaling. These findings also suggest that other known microcephaly genes implicated in either DNA repair responses or centrosomal function may act in common developmental pathways determining human brain and body size
The cosmic ray positron excess and neutralino dark matter
Using a new instrument, the HEAT collaboration has confirmed the excess of
cosmic ray positrons that they first detected in 1994. We explore the
possibility that this excess is due to the annihilation of neutralino dark
matter in the galactic halo. We confirm that neutralino annihilation can
produce enough positrons to make up the measured excess only if there is an
additional enhancement to the signal. We quantify the `boost factor' that is
required in the signal for various models in the Minimal Supersymmetric
Standard Model parameter space, and study the dependence on various parameters.
We find models with a boost factor greater than 30. Such an enhancement in the
signal could arise if we live in a clumpy halo. We discuss what part of
supersymmetric parameter space is favored (in that it gives the largest
positron signal), and the consequences for other direct and indirect searches
of supersymmetric dark matter.Comment: 11 pages, 6 figures, matches published version (PRD
Effect of halo modelling on WIMP exclusion limits
WIMP direct detection experiments are just reaching the sensitivity required
to detect galactic dark matter in the form of neutralinos. Data from these
experiments are usually analysed under the simplifying assumption that the
Milky Way halo is an isothermal sphere with maxwellian velocity distribution.
Observations and numerical simulations indicate that galaxy halos are in fact
triaxial and anisotropic. Furthermore, in the cold dark matter paradigm
galactic halos form via the merger of smaller subhalos, and at least some
residual substructure survives. We examine the effect of halo modelling on WIMP
exclusion limits, taking into account the detector response. Triaxial and
anisotropic halo models, with parameters motivated by observations and
numerical simulations, lead to significant changes which are different for
different experiments, while if the local WIMP distribution is dominated by
small scale clumps then the exclusion limits are changed dramatically.Comment: 9 pages, 9 figures, version to appear in Phys. Rev. D, minor change
A critical review of the formation of mono- and dicarboxylated metabolic intermediates of alkylphenol polyethoxylates during wastewater treatment and their environmental significance
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Taylor & Francis.Alkylphenoxyacetic acids, the metabolic biodegradation products of alkylphenol ethoxylates, are commonly found in wastewaters and sewage effluents. These persistent hydrophilic derivatives possess intrinsic estrogenic activity, which can mimic natural hormones. Their concentrations increase through the sewage treatment works as a result of biodegradation and biotransformation, and when discharged can disrupt endocrine function in fish. These acidic metabolites represent the dominant alkylphenolic compounds found in wastewater effluent and their presence is cause for concern as, potentially, through further biotransformation and biodegradation, they can act as sources of nonylphenol, which is toxic and estrogenic. The authors aim to assess the mechanisms of formation as well as elimination of alkylphenoxyacetic acids within conventional sewage treatment works with the emphasis on the activated sludge process. In addition, they evaluate the various factors influencing their degradation and formation in laboratory scale and full-scale systems. The environmental implications of these compounds are considered, as is the need for tertiary treatment processes for their removal
Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704
Double hit lymphoma (DHL) and double protein-expressing (MYC and BCL2) lymphomas (DPL) fare poorly with R-CHOP; consolidative autologous stem cell transplant (ASCT) may improve outcomes. S9704, a phase III randomized study of CHOP +/−R with or without ASCT allows evaluation of intensive consolidation. Immunohistochemical analysis identified 27 of 198 patients (13.6%) with MYC IHC overexpression and 20 (74%) harboring concurrent BCL2 overexpression. Four had DHL and 16 had DPL only. With median follow-up 127 months, there is a trend favoring outcomes after consolidative ASCT in DPL and MYC protein overexpressing patients, whereas all DHL patients have died irrespective of ASCT
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome
A homozygous mutational change in the Ataxia-Telangiectasia and RAD3 related (ATR) gene was previously reported in two related families displaying Seckel Syndrome (SS). Here, we provide the first identification of a Seckel Syndrome patient with mutations in ATRIP, the gene encoding ATR-Interacting Protein (ATRIP), the partner protein of ATR required for ATR stability and recruitment to the site of DNA damage. The patient has compound heterozygous mutations in ATRIP resulting in reduced ATRIP and ATR expression. A nonsense mutational change in one ATRIP allele results in a C-terminal truncated protein, which impairs ATR-ATRIP interaction; the other allele is abnormally spliced. We additionally describe two further unrelated patients native to the UK with the same novel, heterozygous mutations in ATR, which cause dramatically reduced ATR expression. All patient-derived cells showed defective DNA damage responses that can be attributed to impaired ATR-ATRIP function. Seckel Syndrome is characterised by microcephaly and growth delay, features also displayed by several related disorders including Majewski (microcephalic) osteodysplastic primordial dwarfism (MOPD) type II and Meier-Gorlin Syndrome (MGS). The identification of an ATRIP-deficient patient provides a novel genetic defect for Seckel Syndrome. Coupled with the identification of further ATR-deficient patients, our findings allow a spectrum of clinical features that can be ascribed to the ATR-ATRIP deficient sub-class of Seckel Syndrome. ATR-ATRIP patients are characterised by extremely severe microcephaly and growth delay, microtia (small ears), micrognathia (small and receding chin), and dental crowding. While aberrant bone development was mild in the original ATR-SS patient, some of the patients described here display skeletal abnormalities including, in one patient, small patellae, a feature characteristically observed in Meier-Gorlin Syndrome. Collectively, our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be define
- …