Assessment of Vegetative Phenology with Respect to Leaf Elongation Pattern of Avicennia Marina and Rhizophora Mucronata in Hajambro Creek, Indus Delta, Pakistan

Leaves emergence and the rate of elongation have been studied in Hajambro creek in Indus deltaic region, Pakistan. Leaves emergence was found higher during the summer months (mostly pre-monsoon period), that was March April, May and June. Leaves of A. marina that were observed from March to July, till the leaves reached their maximum length (about 77 mm), showed a gradual increase in their length, reaching maximum in April. Leaves of Avicennia marina reached their maximum length (about 77 mm) in about 113 days. The leaves showed gradual increase in their length, reaching maximum in April (0.97mm d-1). The per-day increment in length was 0.54 mm d-1. As reaching their maximum length (77mm), the per-day increment in the length gradually slower down. The leaves of Rhizophora mucronata were observed from February to November. The leaves of Rhizophora mucronata showed elongation rate of 0.24 mm d-1 from the day of the first observation till the leaves reached their maximum length (120 mm). The maximum time required by the leaves to reach their maximum length (120 mm) was 236 days. The rates of elongation of leaves are also fast in summer. The rate of elongation of the leaves was found to be highly correlated with the temperature (

Note on flat foliations of spherically symmetric spacetimes

It is known that spherically symmetric spacetimes admit flat spacelike foliations. We point out a simple method of seeing this result via the Hamiltonian constraints of general relativity. The method yields explicit formulas for the extrinsic curvatures of the slicings.Comment: 4 pages, to appear in PRD, reference added, typos correcte

Characterization of quality indices on storage of puree of mutant (dg and og^c) and normal tomatoes

The investigations carried out so far on high pigment tomatoes are confined to their nutritional aspects only. We present the comparative results of the first study on the kinetics of changes in chemical and sensory quality attributes in puree prepared from two colour mutants [dark green (dg) and old gold crimson (ogc)] and seven normal tomato genotypes during storage. Puree of mutant tomatoes BCT-115 and BCT-119, carrying dg and ogc genes, showed the less significant changes in TSS (7.52 and 6.02 °Brix), acidity (3.16 and 3.05%), pH (4.04 and 4.03), total sugar (12.4 and 11.13%), ascorbic acid (20.74 and 19.69 mg/100 g), lycopene (7.78 and 542 mg/100 g), and β-carotene (3.08 and 2.26 mg/100 g) during two months storage at 25 °C. Nevertheless, puree prepared from Berika and BCT-115 (dg) had higher colour (7.63 and 7.13), taste (7.4 and 7.37) and flavour (7.3 and 7.37) sensory scores during two months of storage at 25°C. These results provide new data on the effect of genotypes on the stability of quality for storage of tomato puree and insist on the utilization of these genotypes for breeding new processing cultivars in the near future

High- and low energy nonthermal X-ray emission from the cluster of galaxies A 2199

We report the detection of both soft and hard excess X-ray emission in the cluster of galaxies A 2199, based upon spatially resolved spectroscopy with data from the BeppoSAX, EUVE and ROSAT missions. The excess emission is visible at radii larger than 300 kpc and increases in strength relative to the isothermal component. The total 0.1-100 keV luminosity of this component is 15 % of the cluster luminosity, but it dominates the cluster luminosity at high and low energies. We argue that the most plausible interpretation of the excess emission is an inverse Compton interaction between the cosmic microwave background and relativistic electrons in the cluster. The observed spatial distribution of the non-thermal component implies that there is a large halo of cosmic ray electrons between 0.5-1.5 Mpc surrounding the cluster core. The prominent existence of this component has cosmological implications, as it is significantly changing our picture of a clusters's particle acceleration history, dynamics between the thermal and relativistic media, and total mass budgets.Comment: Accepted for publication in Astrophysical Journal, Letter

Perturbation of Interaction Networks for Application to Cancer Therapy

We present a computational approach for studying the effect of potential drug combinations on the protein networks associated with tumor cells. The majority of therapeutics are designed to target single proteins, yet most diseased states are characterized by a combination of many interacting genes and proteins. Using the topology of protein-protein interaction networks, our methods can explicitly model the possible synergistic effect of targeting multiple proteins using drug combinations in different cancer types

PATIENT PROTECTION AND AFFORDABLE CARE ACT OF 2010: Advancing Health Equity for Racially and Ethnically Diverse Populations

Racial/ethnic disparities in health and health care in the United States are persistent and well documented. Communities of color fare far worse than their white counterparts across a range of health indicators: life expectancy, infant mortality, prevalence of chronic diseases, self-rated health status, insurance coverage, and many others.1 As the nation’s population continues to become increasingly diverse—people of color are projected to comprise 54% of the U.S. population by 2050 and more than half of U.S. children by 20232— these disparities are likely to grow if left unaddressed. Recent health care reform legislation, while not a panacea for eliminating health disparities, off ers an important fi rst step and an unprecedented opportunity to improve health equity in the United States. Reforming the nation’s health care system was President Obama’s top domestic priority when he was sworn into offi ce in January 2009. Th e road to reform was complex and unoffi cially started in summer of 2009 when House and Senate committees began to draft legislation. On November 7, 2009, the House of Representatives passed its health care reform proposal, Th e Aff ordable Health Choices Act of 2009 (H.R. 3962). On December 24, 2009, the Senate passed its own proposal for health care reform, Th e Patient Protection and Aff ordable Care Act (H.R. 3590)*, which was a merged version of the Senate Finance Committee’s America’s Health Future Act (S.1796) and the Senate Committee on Health, Education, Labor, and Pensions’ Aff ordable Health Choices Act (S. 1697).† Eff orts to reconcile diff erences between the Senate and House bills were stymied by the death of Senator Edward Kennedy (D-MA), a lifelong proponent of health care reform and critical force in securing a proposal’s passage in the Senate. Faced with limited options and expecting that a compromise bill could not get Senate support, the House passed the Senate’s proposal and Th e Patient Protection and Aff ordable Care Act (ACA) was signed into law by President Obama on March 23, 2010 (Pub. L. No. 111-148).‡ On March 30, 2010, the ACA was amended by Th e Health Care and Education Reconciliation Act of 2010 (H.R. 4872). According to Congressional Budget Offi ce (CBO) estimates, the ACA, as reconciled by H.R. 4872, will reduce the defi cit by $143 billion over the next decade and decrease the number of non-elderly uninsured by 32 million, leaving 23 million uninsured— approximately one-third of whom would be undocumented immigrants.3 Th is report provides a comprehensive review of general and specifi c ACA provisions with the potential to signifi cantly improve health and health care for millions of diverse populations and their communities. Th e narrative that follows identifi es these provisions, discusses why they are important, and considers challenges that may lie ahead in implementing them. We have organized this presentation in three major sections. Th e next section discusses provisions that explicitly address health disparities, such as those concerning data collection by race/ethnicity, workforce diversity, cultural competence, health disparities research, health disparities initiatives in prevention, and health equity in health insurance reform, and discusses their implications for racially and ethnically diverse communities. Section III describes general provisions, including health insurance reforms, access to care, quality improvement, cost containment, public health and social determinants of health, all of which are likely to have major implications for diverse communities. An accompanying appendix identifi es these provisions, provides a timetable and, where identifi ed in the legislation, the federal agencies responsible for implementation, as well as allocations as of June 30, 2010. Section IV discusses issues that will be critical in realizing the full potential of health care reform and highlights questions and directions for the future, particularly in context of important priorities for reducing racial/ethnic health disparities that were left unaddressed

Mass Profiles of the Typical Relaxed Galaxy Clusters A2199 and A496

We present maps and radial profiles of the gas temperature in the nearby galaxy clusters A2199 and A496, which have the most accurate ASCA spectral data for all hot clusters. These clusters are relaxed and can provide reliable X-ray mass measurements under the assumption of hydrostatic equilibrium. The cluster average temperatures corrected for the presence of cooling flows are 4.8+-0.2 keV and 4.7+-0.2 keV (90% errors), respectively. Outside the central cooling flow regions, the radial temperature profiles are similar to those of the majority of nearby relaxed clusters. They are accurately described by polytropic models with gamma=1.17+-0.07 for A2199 and gamma=1.24+-0.09 for A496. We use these polytropic models to derive accurate total mass profiles. Within r=0.5/h Mpc, which corresponds to a radius of overdensity 1000, the total mass values are 1.45+-0.15 10^14 /h Msun and 1.55+-0.15 10^14 /h Msun. These values are 10% lower than those obtained assuming constant temperature. The values inside a gas core radius (0.07-0.13/h Mpc) are a factor of >1.5 higher than the isothermal values. The gas mass fraction increases with radius (by a factor of 3 between the X-ray core radius and r_1000) and at r_1000 reaches values of 0.057+-0.005 and 0.056+-0.006 h^-3/2 for the two clusters, respectively. Our mass profiles within r_1000 are remarkably well approximated by the NFW "universal" profile. Since A2199 and A496 are typical relaxed clusters, the above findings should be relevant for most such systems. In particular, the similarity of the temperature profiles in nearby clusters appears to reflect the underlying "universal" dark matter profile. The upward revision of mass at small radii will resolve most of the discrepancy between the X-ray and strong lensing mass estimates. (Abridged)Comment: Latex, 9 pages, 6 figures, uses emulateapj.sty. Submitted to Ap

Cost variation analysis of antipsychotic drugs available in Indian market: an economic perspective

Background: Pricing of drugs plays a very important role in a developing country like India especially in the management of chronic conditions. There exists a huge price variation among the different brands of the same drug. Hence this study was planned to find out variation in prices of antipsychotic drugs marketed in India. The objective was to compare the percentage price variation and cost ratio of various formulations of oral and parenteral antipsychotic drugs available in the Indian market.Methods: Cost of oral and parenteral antipsychotic drugs available in the Indian market manufactured by different companies, in the same strength, number and dosage form was obtained from http://www.medguideindia.com. The percentage price variation and cost ratio of each formulation was calculated.Results: Among the typical group of antipsychotic drugs, Tab Haloperidol 0.25mg shows maximum price variation of 650% and a cost ratio of 7.5 followed by Tab Trifluoperazine 1mg having a price variation of 555.5% and a cost ratio of 6.55. Among the atypical group of drugs, tab Risperidone 3mg shows a price variation of 2282.35% with a cost ratio of 23.82 followed by Tab Risperidone 4mg with a price variation of 1976.92 % and a cost ratio of 20.76.Conclusions: There is a wide variation between the minimum and maximum cost among the different brands of the same drug in the same formulations. Combined efforts are needed from the regulatory authorities, pharmaceutical companies, physicians and pharmacist towards controlling the prices and attaining maximum economic benefits for the patient