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Interrogating cellular perception and decision making with optogenetic tools.
Optogenetics promises to deepen our understanding of how cells perceive and respond to complex and dynamic signals and how this perception regulates normal and abnormal function. In this study, we present our vision for how these nascent tools may transform our view of fundamental cell biological processes
Making information accessible for the conservation and use of biodiversity. A novel initiative to facilitate access to information and use of agricultural and tree biodiversity
Poster presented at Science Week 2014 - Bioversity International HQ, Rome (Italy), 24-27 Feb 201
A Solid State Pulsed Coagulating Diathermy Instrument
Solid state pulsed coagulating diathermy instrumen
Design zero-voltage switching DC-DC buck converter
This report proposes an integrated, high switching frequency, zero-voltage-switching
dc-dc buck converter for battery charger application. The design and analysis of dc�dc buck converter with integrated inductor is presented. The converter has been
optimized to convert 12V input voltage to 5V at 1.5A maximum load current at
50MHz switching frequency. The converter has been simulated using an ORCAD
16.5 based simulation tool and result show that the switching losses using zero�voltage-switching technique is less compared to conventional buck converter
Discovery of Radio Emission from the Tight M8 Binary: LP 349-25
We present radio observations of 8 ultracool dwarfs with a narrow spectral
type range (M8-M9.5) using the Very Large Array at 8.5 GHz. Only the tight M8
binary LP 349-25 was detected. LP 349-25 is the tenth ultracool dwarf system
detected in radio and its trigonometric parallax pi = 67.6 mas, recently
measured by Gatewood et al., makes it the furthest ultracool system detected by
the Very Large Array to date, and the most radio-luminous outside of obvious
flaring activity or variability. With a separation of only 1.8 AU, masses of
the components of LP 349-25 can be measured precisely without any theoretical
assumptions (Forveille et al.), allowing us to clarify their fully-convective
status and hence the kind of magnetic dynamo in these components which may play
an important role to explain our detection of radio emission from these
objects. This also makes LP 349-25 an excellent target for further studies with
better constraints on the correlations between X-ray, radio emission and
stellar parameters such as mass, age, temperature, and luminosity in ultracool
dwarfs.Comment: accepted by ApJ, referee's comments included, typo in equation 1
correcte
Filling the Void: A Low Cost, High-Yield Method to Addressing Incidental Findings in Trauma Patients
In this study we:
Report the incidence of incidental findings in a suburban trauma center treating primarily blunt and elderly trauma
Propose simple solutions to increase the rate of disclosure to patientshttps://jdc.jefferson.edu/patientsafetyposters/1070/thumbnail.jp
Measurement of Spin Polarization by Andreev Reflection in Ferromagnetic In1-xMnxSb Epilayers
We carried out Point Contact Andreev Reflection (PCAR) spin spectroscopy
measurements on epitaxially-grown ferromagnetic In1-xMnxSb epilayers with a
Curie temperature of ~9K. The spin sensitivity of PCAR in this material was
demonstrated by parallel control studies on its non-magnetic analog,
In1-yBeySb. We found the conductance curves of the Sn point contacts with
In1-yBeySb to be fairly conventional, with the possible presence of
proximity-induced superconductivity effects at the lowest temperatures. The
experimental Z-values of interfacial scattering agreed well with the estimates
based on the Fermi velocity mismatch between the semiconductor and the
superconductor. These measurements provided control data for subsequent PCAR
measurements on ferromagnetic In1-xMnxSb, which indicated spin polarization in
In1-xMnxSb to be 52 +- 3%
Investigating the benefits of molecular profiling of advanced non-small cell lung cancer tumors to guide treatments.
In this study we utilized data on patient responses to guided treatments, and we evaluated their benefit for a non-small cell lung cancer cohort. The recommended therapies used were predicted using tumor molecular profiles that involved a range of biomarkers but primarily used immunohistochemistry markers. A dataset describing 91 lung non-small cell lung cancer patients was retrospectively split into two. The first group's drugs were consistent with a treatment plan whereby all drugs received agreed with their tumor's molecular profile. The second group each received one or more drug that was expected to lack benefit. We found that there was no significant difference in overall survival or mortality between the two groups. Patients whose treatments were predicted to be of benefit survived for an average of 402 days, compared to 382 days for those that did not (P = 0.7934). In the matched treatment group, 48% of patients were deceased by the time monitoring had finished compared to 53% in the unmatched group (P = 0.6094). The immunohistochemistry biomarker for the ERCC1 receptor was found to be a marker that could be used to predict future survival; ERCC1 loss was found to be predictive of poor survival
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