Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials

BACKGROUND: Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative reviews are rare; this one evaluates the effects of chlorpromazine in the treatment of schizophrenia in comparison with placebo. METHODS: We sought all relevant randomised controlled trials (RCT) comparing chlorpromazine to placebo by electronic and reference searching, and by contacting trial authors and the pharmaceutical industry. Data were extracted from selected trials and, where possible, synthesised and random effects relative risk (RR), the number needed to treat (NNT) and their 95% confidence intervals (CI) calculated. RESULTS: Fifty RCTs from 1955–2000 were included with 5276 people randomised to CPZ or placebo. They constitute 2008 person-years spent in trials. Meta-analysis of these trials showed that chlorpromazine promotes a global improvement (n = 1121, 13 RCTs, RR 0.76 CI 0.7 to 0.9, NNT 7 CI 5 to 10), although a considerable placebo response is also seen. People allocated to chlorpromazine tended not to leave trials early in both the short (n = 945, 16 RCTs, RR 0.74 CI 0.5 to 1.1) and medium term (n = 1861, 25 RCTs, RR 0.79 CI 0.6 to 1.1). There were, however, many adverse effects. Chlorpromazine is sedating (n = 1242, 18 RCTs, RR 2.3 CI 1.7 to 3.1, NNH 6 CI 5 to 8), increases a person's chances of experiencing acute movement disorders, Parkinsonism and causes low blood pressure with dizziness and dry mouth. CONCLUSION: It is understandable why the World Health Organization (WHO) have endorsed and included chlorpromazine in their list of essential drugs for use in schizophrenia. Low- and middle-income countries may have more complete evidence upon which to base their practice compared with richer nations using recent innovations

Search for B+ -> l+ nu gamma decays with hadronic tagging using the full Belle data sample

We search for the decay B+ -> l+ nu gamma with l+ = e+ or mu+ using the full Belle data set of 772 x 10^6 BBbar pairs, collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We reconstruct one B meson in a hadronic decay mode and search for the B+ -> l+ nu gamma decay in the remainder of the event. We observe no significant signal within the phase space of E_gamma^sig > 1 GeV and obtain upper limits of BR(B+ -> e+ nu gamma) mu+ nu gamma) l+ nu gamma) < 3.5 x 10^-6 at 90 % credibility level.Comment: Submitted to Phys. Rev.

Measurement of the τ\tau lepton polarization and R(D∗)R(D^*) in the decay Bˉ→D∗τ−νˉτ\bar{B} \to D^* \tau^- \bar{\nu}_\tau

We report the first measurement of the $\tau$ lepton polarization $P_\tau(D^*)$ in the decay $\bar{B} \rightarrow D^* \tau^- \bar{\nu}_\tau$ as well as a new measurement of the ratio of the branching fractions $R(D^{*}) = \mathcal{B}(\bar {B} \rightarrow D^* \tau^- \bar{\nu}_\tau) / \mathcal{B}(\bar{B} \rightarrow D^* \ell^- \bar{\nu}_\ell)$, where $\ell^-$ denotes an electron or a muon, and the $\tau$ is reconstructed in the modes $\tau^- \rightarrow \pi^- \nu_\tau$ and $\tau^- \rightarrow \rho^- \nu_\tau$. We use the full data sample of $772 \times 10^6$ $B{\bar B}$ pairs recorded with the Belle detector at the KEKB electron-positron collider. Our results, $P_\tau(D^*) = -0.38 \pm 0.51 {\rm (stat.)} ^{+0.21}_{-0.16} {\rm (syst.)}$ and $R(D^*) = 0.270 \pm 0.035{\rm (stat.)} ^{+0.028}_{-0.025}{\rm (syst.)}$, are consistent with the theoretical predictions of the Standard Model.Comment: 7 pages, 2 figures, submitted to Physical Review Letters; one figure was removed from the first versio

Measurement of the branching ratio of Bˉ→D(∗)τ−νˉτ\bar{B} \to D^{(\ast)} \tau^- \bar{\nu}_\tau relative to Bˉ→D(∗)ℓ−νˉℓ\bar{B} \to D^{(\ast)} \ell^- \bar{\nu}_\ell decays with hadronic tagging at Belle

We report a measurement of the branching fraction ratios R(D(*)) of Bbar -> D(*) tau- nubar_tau relative to Bbar -> D()* l- nubar_l (where l = e or mu) using the full Belle data sample of 772 x 10^6 BBbar pairs collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. The measured values are R(D)= 0.375 +- 0.064(stat.) +- 0.026(syst.) and R(D*) = 0.293 +- 0.038(stat.) +- 0.015(syst.). The analysis uses hadronic reconstruction of the tag-side B meson and purely leptonic tau decays. The results are consistent with earlier measurements and do not show a significant deviation from the standard model prediction.Comment: Accepted for publication in Phys.Rev.

Search for B→hννˉ\boldsymbol{B\to h\nu\bar{\nu}} decays with semileptonic tagging at Belle

We present the results of a search for the rare decays $B\to h\nu\overline{\nu}$, where $h$ stands for $K^+,\:K^0_{\mathrm{S}},\:K^{\ast +},\:K^{\ast 0},\:\pi^+,\:\pi^0,\:\rho^+$ and $\rho^{0}$. The results are obtained with $772\times10^{6}$ $B\overline{B}$ pairs collected with the Belle detector at the KEKB $e^+ e^-$ collider. We reconstruct one $B$ meson in a semileptonic decay and require a single $h$ meson but nothing else on the signal side. We observe no significant signal and set upper limits on the branching fractions. The limits set on the $B\to K^0_{\mathrm{S}}\nu\overline{\nu}$, $B^0\to K^{*0}\nu\overline{\nu}$, $B\to \pi^+\nu\overline{\nu}$, $B^0\to\pi^0\nu\overline{\nu}$, $B^+\to\rho^+\nu\overline{\nu}$, and $B^0\to\rho^0\nu\overline{\nu}$ channels are the world's most stringent.Comment: Submitted to PR

First Observation of Doubly Cabibbo-Suppressed Decay of a Charmed Baryon: Λc+→pK+π−\Lambda^{+}_{c} \rightarrow p K^{+} \pi^{-}

We report the first observation of the decay $\Lambda^{+}_{c} \rightarrow p K^{+} \pi^{-}$ using a 980 $\mathrm{fb^{-1}}$ data sample collected by the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider. This is the first doubly Cabibbo-suppressed decay of a charmed baryon to be observed. We measure the branching ratio of this decay with respect to its Cabibbo-favored counterpart to be $\mathcal{B}(\Lambda^{+}_{c} \rightarrow p K^{+} \pi^{-})/\mathcal{B}(\Lambda^{+}_{c} \rightarrow p K^{-} \pi^{+})=(2.35\pm0.27\pm0.21)\times10^{-3}$, where the uncertainties are statistical and systematic, respectively.Comment: 6 pages, 3 figure

Angular analysis of B0→K∗(892)0ℓ+ℓ−B^0 \to K^\ast(892)^0 \ell^+ \ell^-

We present a measurement of angular observables, $P_4'$, $P_5'$, $P_6'$, $P_8'$, in the decay $B^0 \to K^\ast(892)^0 \ell^+ \ell^-$, where $\ell^+\ell^-$ is either $e^+e^-$ or $\mu^+\mu^-$. The analysis is performed on a data sample corresponding to an integrated luminosity of $711~\mathrm{fb}^{-1}$ containing $772\times 10^{6}$ $B\bar B$ pairs, collected at the $\Upsilon(4S)$ resonance with the Belle detector at the asymmetric-energy $e^+e^-$ collider KEKB. Four angular observables, $P_{4,5,6,8}'$ are extracted in five bins of the invariant mass squared of the lepton system, $q^2$. We compare our results for $P_{4,5,6,8}'$ with Standard Model predictions including the $q^2$ region in which the LHCb collaboration reported the so-called $P_5'$ anomaly.Comment: Conference paper for LHC Ski 2016. SM prediction for $P_{6}'$ corrected and reference for arXiv:1207.2753 adde