Performance measurements of a pilot superconducting solenoid model core for a wind tunnel magnetic suspension and balance system

The results of experimental demonstrations of a superconducting solenoid model core in the Southampton University Magnetic Suspension and Balance System are detailed. Technology and techniques relevant to large-scale wind tunnel MSBSs comprise the long term goals. The magnetic moment of solenoids, difficulties peculiar to superconducting solenoid cores, lift force and pitching moment, dynamic lift calibration, and helium boil-off measurements are discussed

Using high resolution displays for high resolution cardiac data

The ability to perform fast, accurate, high resolution visualization is fundamental to improving our understanding of anatomical data. As the volumes of data increase from improvements in scanning technology, the methods applied to rendering and visualization must evolve. In this paper we address the interactive display of data from high resolution MRI scanning of a rabbit heart and subsequent histological imaging. We describe a visualization environment involving a tiled LCD panel display wall and associated software which provide an interactive and intuitive user interface. The oView software is an OpenGL application which is written for the VRJuggler environment. This environment abstracts displays and devices away from the application itself, aiding portability between different systems, from desktop PCs to multi-tiled display walls. Portability between display walls has been demonstrated through its use on walls at both Leeds and Oxford Universities. We discuss important factors to be considered for interactive 2D display of large 3D datasets, including the use of intuitive input devices and level of detail aspects

Facing Shadows: working with young people to coproduce a short film about depression

Background: IMPACT (Improving Mood with Psychoanalytic and Cognitive Therapies) is a multi-centre randomised controlled trial of three therapeutic interventions for the treatment of depression in young people. IMPACT- My Experience (IMPACT-ME), a qualitative research study, followed up a sub-sample of families involved in IMPACT to explore young people's experiences of therapy and depression. Members of the IMPACT-ME steering group, who brought their own experiences of depression and engaging with mental health services, were keen to find ways to provide information about depression and help-seeking beyond traditional academic audiences, specifically to other young people experiencing depression and wondering where to turn: their chosen medium was film. Here we describe and reflect on the four-day coproduction workshops in which researchers, young people and film-makers coproduced 'Facing Shadows', a short animation about depression and therapy (https://www.youtube.com/watch?v=LdmRPKUhNEY). Main body: We outline the process, focusing on the four-day creative, collaborative workshop in which young people shared their experiences, decided on the tone, tenor and message of the film, identified their primary audience and produced the bulk of the audio and visual material. The adults acted as facilitators: developing a creative, collaborative learning environment in which trusting relationships could flourish, as well as offering guidance, instruction, advice and support. To date the film has been viewed around 12,000 times on YouTube. The young people learned new skills, felt listened to and enjoyed the process. They produced a film which sends a hopeful message to other young people, '… that they are not alone'. Conclusion: We reflect on the creative participatory workshop approach which transformed the project from dissemination to an insightful learning experience for young people and researchers alike

Adaptive high-order finite element solution of transient elastohydrodynamic lubrication problems

This article presents a new numerical method to solve transient line contact elastohydrodynamic lubrication (EHL) problems. A high-order discontinuous Galerkin (DG) finite element method is used for the spatial discretization, and the standard Crank-Nicolson method is employed to approximate the time derivative. An h-adaptivity method is used for grid adaptation with the time-stepping, and the penalty method is employed to handle the cavitation condition. The roughness model employed here is a simple indentation, which is located on the upper surface. Numerical results are presented comparing the DG method to standard finite difference (FD) techniques. It is shown that micro-EHL features are captured with far fewer degrees of freedom than when using low-order FD methods

Making an effort to feel positive: insecure attachment in infancy predicts the neural underpinnings of emotion regulation in adulthood

Background: Animal research indicates that the neural substrates of emotion regulation may be persistently altered by early environmental exposures. If similar processes operate in human development then this is significant, as the capacity to regulate emotional states is fundamental to human adaptation. Methods: We utilised a 22-year longitudinal study to examine the influence of early infant attachment to the mother, a key marker of early experience, on neural regulation of emotional states in young adults. Infant attachment status was measured via objective assessment at 18-months, and the neural underpinnings of the active regulation of affect were studied using fMRI at age 22 years. Results: Infant attachment status at 18-months predicted neural responding during the regulation of positive affect 20-years later. Specifically, while attempting to up-regulate positive emotions, adults who had been insecurely versus securely attached as infants showed greater activation in prefrontal regions involved in cognitive control and reduced co-activation of nucleus accumbens with prefrontal cortex, consistent with relative inefficiency in the neural regulation of positive affect. Conclusions: Disturbances in the mother–infant relationship may persistently alter the neural circuitry of emotion regulation, with potential implications for adjustment in adulthood

Conservative and disruptive modes of adolescent change in human brain functional connectivity

Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14 to 26 y and were scanned on 1 to 3 occasions at least 6 mo apart. We found 2 distinct modes of age-related change in FC: “conservative” and “disruptive.” Conservative development was characteristic of primary cortex, which was strongly connected at 14 y and became even more connected in the period from 14 to 26 y. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was remodeled: connections that were weak at 14 y became stronger during adolescence, and connections that were strong at 14 y became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearman’s correlation between edgewise baseline FC (at 14 y, FC14) and adolescent change in FC (ΔFC14−26), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data and significantly colocated with prior maps of aerobic glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these 2 modes of development was robust to numerous sensitivity analyses. We conclude that human brain organization is disrupted during adolescence by remodeling of FC between association cortical and subcortical areas

Imagining your child's mind: psychosocial adjustment and mothers' ability to predict their children's attributional response styles

One class of parent-child interaction that has recently received attention is maternal engagement with her child at a mental level. The current study operationalises this notion by asking the mothers of 354 7-11 year old children drawn from a larger community sample (n=659) to guess the responses of their children, who in turn, were asked to attribute thoughts to their peers in distressing peer-related scenarios. The following predictions were made: (1) mothers would be above chance in the accuracy by which they predicted their children’s overal attributional styles (2) increased maternal accuracy would be an important correlate of reduced psychopathology symptoms in children; and (3) poor maternal accuracy would associated with a maladaptive child attributional response style characterised by unrealistic and overly positive attributions. Results suggested that maternal accuracy was normally distributed with mothers accurately guessing the responses of their children for about half of the social scenarios. Mothers were furthermore shown to be above chance in the accuracy by which they predicted their children's overall attributional styles. Maternal accuracy was found to be related to child psychosocial adjustment (reduced scores on child psychopathology measures), whilst poor maternal accuracy was associated with ineffective social-cognitive reasoning, as indexed by an unrealistic and overly positive child attributional style. Findings are discussed within the context of the burgeoning literature linking attachment, family talk about feelings and thoughts and parental mind-mindedness

Corrigendum: Mutualistic Coupling Between Vocabulary and Reasoning Supports Cognitive Development During Late Adolescence and Early Adulthood

Correction to: Kievit, R. A., Lindenberger, U., Goodyer, I. M., Jones, P. B., Fonagy, P., Bullmore, E. T., the Neuroscience in Psychiatry Network, & Dolan, R. J. (2017). Mutualistic coupling between vocabulary and reasoning supports cognitive development during late adolescence and early adulthood. Psychological Science, 28, 1419–1431. doi:10.1177/095679761771078

Simulations of three-dimensional dendritic growth using a coupled thermo-solutal phase-field model

Using a phase field model, which fully couples the thermal and solute concentration field, we present simulation results in three dimensions of the rapid dendritic solidification of a class of dilute alloys at the meso scale. The key results are the prediction of steady state tip velocity and radius at varying undercooling and thermal diffusivities. Less computationally demanding 2-dimensional results are directly compared with the corresponding 3-dimensional results, where significant quantitative differences emerge. The simulations provide quantitative predictions for the range of thermal and solutal diffusivities considered and show the effectiveness and potential of the computational techniques employed. These results thus provide benchmark 3-dimensional computations, allow direct comparison with underlying analytical theory, and pave the way for further quantitative results