A U-shaped protection of altitude against mortality and infection of COVID-19 in Peru: An ecological study

Background The COVID-19 pandemic has affected the world in multiple ways and has been a challenge for the health systems of each country. From the beginning, risk factors for the severity and mortality of the disease were considered, as the spread of the virus was related to the living conditions of each population. Methods In this ecological study we have evaluated the role of geography, precisely the altitude above sea level in the incidence and mortality of COVID-19 in Peru. Incidence and mortality data were taken from the open-access database of the government of Peru until March 2021. COVID-19 cases and COVID-19 mortality were treated as cases/density population and 1000 x cases/inhabitants while altitude was treated as continuous and as a categorical variable divided in 7 categories. The relationship between COVID-19 cases or deaths for COVID-19 and altitude as continuous variable was determined using Spearman correlation test. Meanwhile when altitude was considered as a categorical variable, Poisson regression or negative binomial analyses were applied. Results A significant inverse correlation was found between COVID-19 cases by population density and altitude (r=-0.37 p < 0.001). By altitude categories, the lowest risk for infection was observed between 3,000 and 3,500 m (IRR 0.08; 95% CI 0.05,0.12). Moreover, we found an inverse correlation between altitude and COVID-19 mortality (r=-0.39 p < 0.001). Also, the lowest risk for mortality was observed between 3,000 and 3,500 m (IRR 0.12; 95%CI 0.08; 0.18). Similar results were found when analyses were adjusted for inhabitants and stratified by sex. Conclusion This study reports an inverse relationship between COVID-19 incidence and mortality with respect to the altitude of residence, particularly, a u-shaped protection is shown, with a highest benefit between 3000 and 3500 m. The possibility of using hypoxia as an alternative treatment requires more complex studies that should allow knowing the physiological and environmental mechanisms of the protective role

Hubungan Pengetahuan Dan Sikap Ibu Hamil Dengan Status Gizi Selama Kehamilan Di Puskesmas Bahu Kota Manado

: In general, the causes of malnutrition in pregnant women due to the consumption of foods that do not meet the nutrition requirements. Nutritional is a measure of the success of nutrition for pregnant women. WHO (World Health Organization) recommends an additional amount of 150 kcal a day in the first trimester and 350 kcal a day in the second and third trimester. Low levels of knowledge mother does not understand how to lead fulfilling necessary nutrients pregnant women during pregnancy (Depkes RI, 2002). Nutritional needs during pregnancy will increase per day, despite all the Indonesian people already know the benefits of nutrition for pregnant women, but until now there are many pregnant women who have nutritional problems (Damanik, 2009). The purpose of this study to determine the relationship of knowledge and attitudes of pregnant women with nutritional status during pregnancy on the health center Bahu Manado City. Design of this study used cross sectional method. The population is client pregnant women prenatal care at the health center came Bahu Manado City. The samples in this study were pregnant women at health center clients at Puskesmas Bahu Manado as many as 40 people who have fulfilled the inclusion criteria. The sampling technique used was purposive sampling. Instrument used was a questionnaire and measuring Antrhopometri. Data analysis using SPSS version 16, with Spearman\u27rho test to determine the relationship of knowledge and attitudes of pregnant women with nutritional status. Conclusion knowledge of the nutritional of pregnant women have gained value relationship (p = 0.000 <α0,05) and the attitude of the nutritional of pregnant women have gained value relationship (p = 0.003 <α0,05). Adviceishavea lot of counseling and information for pregnant women to knowledge ful fill mentnutritional status during pregnancy

Insulator-Metal Transition in One Dimension Induced by Long-Range Electronic Interactions

The effects of a long range electronic potential on a one dimensional commensurate Charge Density Wave (CDW) state are investigated. Using numerical techniques it is shown that a transition to a metallic ground state is reached as the range of the electron-electron repulsion increases. In this metallic state, the optical conductivity exhibits a large Drude weight. Possible interpretations of our results are discussed.Comment: 5 pages, Revtex, minor misprints corrected and a reference to earlier work by V. Emery and C. Noguera adde

SBOL-OWL: An ontological approach for formal and semantic representation of synthetic biology information

Standard representation of data is key for the reproducibility of designs in synthetic biology. The Synthetic Biology Open Language (SBOL) has already emerged as a data standard to represent information about genetic circuits, and it is based on capturing data using graphs. The language provides the syntax using a free text document that is accessible to humans only. This paper describes SBOL-OWL, an ontology for a machine understandable definition of SBOL. This ontology acts as a semantic layer for genetic circuit designs. As a result, computational tools can understand the meaning of design entities in addition to parsing structured SBOL data. SBOL-OWL not only describes how genetic circuits can be constructed computationally, it also facilitates the use of several existing Semantic Web tools for synthetic biology. This paper demonstrates some of these features, for example, to validate designs and check for inconsistencies. Through the use of SBOL-OWL, queries can be simplified and become more intuitive. Moreover, existing reasoners can be used to infer information about genetic circuit designs that cannot be directly retrieved using existing querying mechanisms. This ontological representation of the SBOL standard provides a new perspective to the verification, representation, and querying of information about genetic circuits and is important to incorporate complex design information via the integration of biological ontologies

Wigner Crystal in One Dimension

A one--dimensional gas of electrons interacting with long--range Coulomb forces ($V(r) \approx 1/r$) is investigated. The excitation spectrum consists of separate collective charge and spin modes, with the charge excitation energies in agreement with RPA calculations. For arbitrarily weak Coulomb repulsion density correlations at wavevector $4k_F$ decay extremely slowly and are best described as those of a one--dimensional Wigner crystal. Pinning of the Wigner crystal then leads to the nonlinear transport properties characteristic of CDW. The results allow a consistent interpretation of the plasmon and spin excitations observed in one--dimensional semiconductor structures, and suggest an interpretation of some of the observed features in terms of ``spinons''. A possible explanation for nonlinear transport phenomena is given.Comment: 10 pages, RevTe

Semi-supervised source extraction methodology for the nosological imaging of glioblastoma response to therapy.

Glioblastomas are one the most aggressive brain tumors. Their usual bad prognosis is due to the heterogeneity of their response to treatment and the lack of early and robust biomarkers to decide whether the tumor is responding to therapy. In this work, we propose the use of a semi-supervised methodology for source extraction to identify the sources representing tumor response to therapy, untreated/unresponsive tumor, and normal brain; and create nosological images of the response to therapy based on those sources. Fourteen mice were used to calculate the sources, and an independent test set of eight mice was used to further evaluate the proposed approach. The preliminary results obtained indicate that was possible to discriminate response and untreated/unresponsive areas of the tumor, and that the color-coded images allowed convenient tracking of response, especially throughout the course of therapy

Tunneling Between a Pair of Parallel Hall Droplets

In this paper, we examine interwell tunneling between a pair of fractional quantum Hall liquids in a double quantum well system in a tilted magnetic field. Using a variational Monte Carlo method, we calculate moments of the intra-Landau level tunneling spectrum as a function of in-plane field component $B_{\parallel}$ and interwell spacing $d$. This is done for variety of incompressible states including a pair of $\nu=1/3$ layers ([330]), pair of $\nu=1/5$ layers ([550]), and Halperin's [331] state. The results suggest a technique to extract interwell correlations from the tunneling spectral data.Comment: 21 pages and 8 figures (included), RevTeX, preprint no. UCSDCU

Heat content of the Arabian Sea Mini Warm Pool is increasing

© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Atmospheric Science Letters 17 (2016): 39-42, doi:10.1002/asl.596.Sea surface temperature in the Arabian Sea Mini Warm Pool has been suggested to be one of the factors that affects the Indian summer monsoon. In this paper, we analyze the annual ocean heat content (OHC) of this region during 1993–2010, using in situ data, satellite observations, and a model simulation. We find that OHC increases significantly in the region during this period relative to the north Indian Ocean, and propose that this increase could have caused the decrease in Indian Summer Monsoon Rainfall that occurred at the same time

Monitoring the oceanic flow between Africa and Antarctica: Report of the first GoodHope cruise

The southern ocean plays a major role in the global oceanic circulation role in the global oceanic circulation, as a component of the Meridional Overturning Circulation, and it is postulated that it has a great influence on present-day climate. However, our understanding of its complex three-dimensional dynamics and of the impact of its variability on the climate system is rudimentary. The newly constituted, international GoodHope research venture aims to address this knowledge gap by establishing a programme of regular observations across the Southern Ocean between the African and Antarctic continents. The objectives of this programme are fivefold: (1) to improve understanding of Indo-Atlantic inter-ocean exchanges and their impact on the global thermohaline circulation and thus on global climate change; (2) to understand in more detail the influence these exchanges have on the climate variability of the southern African subcontinent; (3) to monitor the variability of the main Southern Ocean frontal systems associated with the Antarctic Circumpolar Current; (4) to study air–sea exchanges and their role on the global heat budget, with particular emphasis on the intense exchanges occurring within the Agulhas Retroflection region south of South Africa, and (5) to examine the role of major frontal systems as areas of elevated biological activity and as biogeographical barriers to the distribution of plankton. We present here preliminary results on the physical and biological structure of the frontal systems using the first GoodHope transect that was completed during February–March 2004