40 research outputs found
Magnetic confinement of the superconducting condensate in superconductor/ferromagnet hybrid composites
The influence of an inhomogeneous magnetic field on the magnetoresistance of
thin Al films, used in different superconductor/ferromagnet hybrids, has been
investigated. Two contrasting magnetic textures with out-of-plane magnetization
are explored, namely (i) a plain film in a multidomain state and (ii) an array
of micro-sized dots. The stray fields of the ferromagnetic structures confine
the superconducting condensate and, accordingly, modify the condition for the
nucleation of superconductivity. By switching between different magnetic states
of the ferromagnet, this confinement can be tuned at will, hereby reversibly
changing the dependence of the critical temperature Tc on an external magnetic
field H. In particular, the continuous evolution from a conventional linear
Tc(H) dependence with a single maximum to a reentrant superconducting phase
boundary with multiple Tc peaks has been demonstrated
Vortex core deformation and stepper motor behavior in a superconducting ratchet
We investigated experimentally the frequency dependence of a superconducting
vortex ratchet effect by means of electrical transport measurements and modeled
it theoretically using the time dependent Ginzburg-Landau formalism. We
demonstrate that the high frequency vortex behavior can be described as a
discrete motion of a particle in a periodic potential, i.e. the so called
stepper motor behavior. Strikingly, in the more conventional low frequency
response a transition takes place from an Abrikosov vortex rectifier to a phase
slip line rectifier. This transition is characterized by a strong increase in
the rectified voltage and the appearance of a pronounced hysteretic behavior.Comment: 4 pages, 4 figure
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Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity. Results: Doxorubicin administration (20 mg/kg, intraperitoneally [IP]) reduced cardiac sGC activity in wild-type (WT) mice. To investigate whether decreased sGC activity contributes to doxorubicin-induced cardiotoxicity, we studied mice with cardiomyocyte-specific deficiency of the sGC alpha 1-subunit (mice with cardiomyocyte-specific deletion of exon 6 of the sGC alpha 1 allele [sGC alpha 1(-/-CM)]). After 12 weeks of doxorubicin administration (2 mg/kg/week IP), left ventricular (LV) systolic dysfunction was greater in sGC alpha 1(-/-CM) than WT mice. To further assess whether reduced sGC activity plays a pathogenic role in doxorubicin-induced cardiotoxicity, we studied a mouse model in which decreased cardiac sGC activity was induced by cardiomyocyte-specific expression of a dominant negative sGC alpha 1 mutant (DNsGC alpha 1) upon doxycycline removal (Tet-off). After 8 weeks of doxorubicin administration, DNsGC alpha 1(tg/+), but not WT, mice displayed LV systolic dysfunction and dilatation. The difference in cardiac function and remodeling between DNsGC alpha 1(tg/+) and WT mice was even more pronounced after 12 weeks of treatment. Further impairment of cardiac function was attenuated when DNsGC alpha 1 gene expression was inhibited (beginning at 8 weeks of doxorubicin treatment) by administering doxycycline. Furthermore, doxorubicin-associated reactive oxygen species generation was higher in sGC alpha 1-deficient than WT hearts. Innovation and Conclusion: These data demonstrate that a reduction in cardiac sGC activity worsens doxorubicin-induced cardiotoxicity in mice and identify sGC as a potential therapeutic target. Various pharmacological sGC agonists are in clinical development or use and may represent a promising approach to limit doxorubicin-associated cardiotoxicity
Distributed information consensus filters for simultaneous input and state estimation
This paper describes the distributed information filtering where a set of sensor networks are required to simultaneously estimate input and state of a linear discrete-time system from collaborative manner. Our research purpose is to develop a consensus strategy in which sensor nodes communicate within the network through a sequence of Kalman iterations and data diffusion. A novel recursive information filtering is proposed by integrating input estimation error into measurement data and weighted information matrices. On the fusing process, local system state filtering transmits estimation information using the consensus averaging algorithm, which penalizes the disagreement in a dynamic manner. A simulation example is provided to compare the performance of the distributed information filtering with optimal Gillijins–De Moor’s algorithm
Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase α1
Objective: Soluble guanylate cyclase (sGC), a heterodimer composed of α and β subunits, synthesizes cGMP in response to nitric oxide (NO). NO modulates vascular tone and structure but the relative contributions of cGMP-dependent versus cGMP-independent mechanisms remain uncertain. We studied the response to vascular injury in male (M) and female (F) mice with targeted deletion of exon 6 of the sGCα1 subunit (sGCα1-/-), resulting in a non-functional heterodimer. Methods: We measured aortic cGMP levels and mRNA transcripts encoding sGC α1, α2, and β1 subunits in wild type (WT) and sGCa1-/- mice. To study the response to vascular injury, BrdU-incorporation and neointima formation (maximum intima to media (I/M) ratio) were determined 5 and 28 days after carotid artery ligation, respectively. Results: Aortic cGMP levels were 4-fold higher in F than in M mice in both genotypes, and, within each gender, 4-fold higher in WT than in sGCa1-/-. In contrast, sGCα1, sGCα2, and sGCβ1 mRNA expression did not differ between groups. 3H-thymidine incorporation in cultured sGCa1-/- smooth muscle cells (SMC) was 27%±12% lower than in WT SMC and BrdU-incorporation in carotid arteries 5 days after ligation was significantly less in sGCa1-/- M than in WT M. Neointima area and I/M 28 days after ligation were 65% and 62% lower in sGCa1-/- M than in WT M mice (p<0,05 for both) but were not different in F mice. Conclusion: Functional deletion of sGCa1 resulted in reduced cGMP levels in male sGCa1-/- mice and a gender-specific effect on the adaptive response to vascular injury
Nucleation of superconductivity and vortex matter in superconductor - ferromagnet hybrids
The theoretical and experimental results concerning the thermodynamical and
low-frequency transport properties of hybrid structures, consisting of
spatially-separated conventional low-temperature superconductor (S) and
ferromagnet (F), is reviewed. Since the superconducting and ferromagnetic parts
are assumed to be electrically insulated, no proximity effect is present and
thus the interaction between both subsystems is through their respective
magnetic stray fields. Depending on the temperature range and the value of the
external field H_{ext}, different behavior of such S/F hybrids is anticipated.
Rather close to the superconducting phase transition line, when the
superconducting state is only weakly developed, the magnetization of the
ferromagnet is solely determined by the magnetic history of the system and it
is not influenced by the field generated by the supercurrents. In contrast to
that, the nonuniform magnetic field pattern, induced by the ferromagnet,
strongly affect the nucleation of superconductivity leading to an exotic
dependence of the critical temperature T_{c} on H_{ext}. Deeper in the
superconducting state the effect of the screening currents cannot be neglected
anymore. In this region of the phase diagram various aspects of the interaction
between vortices and magnetic inhomogeneities are discussed. In the last
section we briefly summarize the physics of S/F hybrids when the magnetization
of the ferromagnet is no longer fixed but can change under the influence of the
superconducting currents. As a consequence, the superconductor and ferromagnet
become truly coupled and the equilibrium configuration of this "soft" S/F
hybrids requires rearrangements of both, superconducting and ferromagnetic
characteristics, as compared with "hard" S/F structures.Comment: Topical review, submitted to Supercond. Sci. Tech., 67 pages, 33
figures, 439 reference
Superconducting spintronics
The interaction between superconducting and spin-polarized orders has recently emerged as a major research field following a series
of fundamental breakthroughs in charge transport in superconductor-ferromagnet heterodevices which promise new device
functionality. Traditional studies which combine spintronics and superconductivity have mainly focused on the injection of
spin-polarized quasiparticles into superconducting materials. However, a complete synergy between superconducting and magnetic
orders turns out to be possible through the creation of spin-triplet Cooper pairs which are generated at carefully engineered
superconductor interfaces with ferromagnetic materials. Currently, there is intense activity focused on identifying materials
combinations which merge superconductivity and spintronics in order to enhance device functionality and performance. The results
look promising: it has been shown, for example, that superconducting order can greatly enhance central effects in spintronics such as
spin injection and magnetoresistance. Here, we review the experimental and theoretical advances in this field and provide an outlook
for upcoming challenges related to the new concept of superconducting spintronics.J.L. was supported by the Research Council of Norway, Grants No. 205591 and 216700.
J.W.A.R. was supported by the UK Royal Society and the Leverhulme Trust through an
International Network Grant (IN-2013-033).This is the accepted manuscript. The final version is available at http://www.nature.com/nphys/journal/v11/n4/full/nphys3242.html
Asymmetric Optical Second-Harmonic Generation from Chiral G-Shaped Gold Nanostructures
We present a new electromagnetic phenomenon-the asymmetric second-harmonic generation from planar chiral structures. The effect consists in distinguishing the handedness of a chiral material by rotating the sample in an experiment involving solely linearly polarized light. This phenomenon originates in the surface plasmon resonance of chiral gold nanostructures, where homodyne interference of anisotropic and chiral electric and/or magnetic multipoles appears to play an important role
Gender-specific modulation of baseline vascular function and the response to arterial injury by soluble guanylate cyclase
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