Investment project management model of opening open-pit coal mines.

Brze promene u okruženju pred rukovodioce postavljaju mnogobrojne zahteve, pre svega, one koji se tiču ostvarenja ciljeva u zadatom vremenu i raspoloživim sredstvima što zahteva fleksibilan pristup u organizovanju aktivnosti i efikasnost u njihovom sprovođenju. Upravljanje projektima, bilo koje vrste, suštinski, predstavlja veoma složen proces odlučivanja uslovljen velikim brojem ulaznih faktora. Ti faktori treba da omoguće fokusiranje na prioritete i ciljeve, praćenje realizacije, fleksibilnost u prevazilaženju teškoća, prilagođavanje promenama, te kontrolu nad ostvarenim rezultatima. Ovakav način upravljanja zahteva korišćenje proverenih tehnika i alata te timski rad angažovanih na projektu, kako bi se rezultati postigli u planiranom vremenu i sa planiranim sredstvima. Odgovor na ova pitanja su preko svojih metodologija pokušali da daju mnogi autori, poznati svetski instituti za upravljanje projektima, među kojima je i PMI (Project management Institute USA), čije preporuke i smernice su, u značajnoj meri, poslužile kod izrade ove disertacije. U savremenom dobu površinska eksploatacija ležišta mineralnih sirovina, usled velikog broja nepoznanica, obavlja se u sve složenijim uslovima, koje sa aspekta projektovanja, planiranja i pripreme za eksploataciju, te samog procesa odvijanja eksploatacije predstavljaju ograničavajuće faktore. Kada je reč o površinskoj eksploataciji uglja, usled niza specifičnosti koje je odlikuju, navedena problematika postaje još izraženija. Po pravilu, realizacija projekata ovog tipa, predstavlja vrlo složen proces sastavljen od višedimenzionalnih aktivnosti ispitivanja svih relevantnih determinanti budućih stanja i promena koje projekat nosi sa sobom. Sa druge strane, razvoj i nova saznanja u drugim naučnim oblastima na koje se oslanja rudarska nauka, pružaju sve šire mogućnosti njene primene.Rapid changes in the environment set numerous requirements before the managers. The aforementioned requirements are primarily related to the achievement of objectives within the given time and resources available, which requires a flexible approach to organisation of activities and efficiency in their implementation. Project management of any kind, is essentially a very complex decision-making process conditioned by a large number of input factors. Such factors should allow to focus onto the priorities and objectives, to monitor the implementation, provide flexibility in overcoming any difficulties, enable adaptation to changes and provide control over the results obtained. This management method requires the use of proven techniques and tools, as well as of teamwork involved in the project in order to achieve the results within the planned time and by using planned resources. The answer to these questions was sought and given, via various methodologies, by many authors, world-renowned project management institutes, including the PMI (Project Management Institute, USA), whose recommendations and guidelines have been used, to a significant degree, in the preparation of this dissertation. In modern times, surface mining of mineral deposits, due to the large number of unknowns, is performed in increasingly complex conditions which in terms of design, planning, mining preparation and the mining process represent the limiting factors. When it comes to surface coal mining, due to a number of specific features characterising it, the above problems become even more pronounced. As a rule, the implementation of such projects is a very complex process consisting of multidimentional testing activities of all relevant determinants of future conditions and changes that the project entails. On the other hand, the development and new knowledge in other scientific areas the mining science relies on, provide continuously expanding possibilities of its application. Taking all theabove into account, the standard approach of project management cannot fully provide for all the complexity of mining projects. Therefore, it is required..

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme

Investment project management model of opening open-pit coal mines.

Brze promene u okruženju pred rukovodioce postavljaju mnogobrojne zahteve, pre svega, one koji se tiču ostvarenja ciljeva u zadatom vremenu i raspoloživim sredstvima što zahteva fleksibilan pristup u organizovanju aktivnosti i efikasnost u njihovom sprovođenju. Upravljanje projektima, bilo koje vrste, suštinski, predstavlja veoma složen proces odlučivanja uslovljen velikim brojem ulaznih faktora. Ti faktori treba da omoguće fokusiranje na prioritete i ciljeve, praćenje realizacije, fleksibilnost u prevazilaženju teškoća, prilagođavanje promenama, te kontrolu nad ostvarenim rezultatima. Ovakav način upravljanja zahteva korišćenje proverenih tehnika i alata te timski rad angažovanih na projektu, kako bi se rezultati postigli u planiranom vremenu i sa planiranim sredstvima. Odgovor na ova pitanja su preko svojih metodologija pokušali da daju mnogi autori, poznati svetski instituti za upravljanje projektima, među kojima je i PMI (Project management Institute USA), čije preporuke i smernice su, u značajnoj meri, poslužile kod izrade ove disertacije. U savremenom dobu površinska eksploatacija ležišta mineralnih sirovina, usled velikog broja nepoznanica, obavlja se u sve složenijim uslovima, koje sa aspekta projektovanja, planiranja i pripreme za eksploataciju, te samog procesa odvijanja eksploatacije predstavljaju ograničavajuće faktore. Kada je reč o površinskoj eksploataciji uglja, usled niza specifičnosti koje je odlikuju, navedena problematika postaje još izraženija. Po pravilu, realizacija projekata ovog tipa, predstavlja vrlo složen proces sastavljen od višedimenzionalnih aktivnosti ispitivanja svih relevantnih determinanti budućih stanja i promena koje projekat nosi sa sobom. Sa druge strane, razvoj i nova saznanja u drugim naučnim oblastima na koje se oslanja rudarska nauka, pružaju sve šire mogućnosti njene primene.Rapid changes in the environment set numerous requirements before the managers. The aforementioned requirements are primarily related to the achievement of objectives within the given time and resources available, which requires a flexible approach to organisation of activities and efficiency in their implementation. Project management of any kind, is essentially a very complex decision-making process conditioned by a large number of input factors. Such factors should allow to focus onto the priorities and objectives, to monitor the implementation, provide flexibility in overcoming any difficulties, enable adaptation to changes and provide control over the results obtained. This management method requires the use of proven techniques and tools, as well as of teamwork involved in the project in order to achieve the results within the planned time and by using planned resources. The answer to these questions was sought and given, via various methodologies, by many authors, world-renowned project management institutes, including the PMI (Project Management Institute, USA), whose recommendations and guidelines have been used, to a significant degree, in the preparation of this dissertation. In modern times, surface mining of mineral deposits, due to the large number of unknowns, is performed in increasingly complex conditions which in terms of design, planning, mining preparation and the mining process represent the limiting factors. When it comes to surface coal mining, due to a number of specific features characterising it, the above problems become even more pronounced. As a rule, the implementation of such projects is a very complex process consisting of multidimentional testing activities of all relevant determinants of future conditions and changes that the project entails. On the other hand, the development and new knowledge in other scientific areas the mining science relies on, provide continuously expanding possibilities of its application. Taking all theabove into account, the standard approach of project management cannot fully provide for all the complexity of mining projects. Therefore, it is required..

Investment project management model of opening open-pit coal mines.

Brze promene u okruženju pred rukovodioce postavljaju mnogobrojne zahteve, pre svega, one koji se tiču ostvarenja ciljeva u zadatom vremenu i raspoloživim sredstvima što zahteva fleksibilan pristup u organizovanju aktivnosti i efikasnost u njihovom sprovođenju. Upravljanje projektima, bilo koje vrste, suštinski, predstavlja veoma složen proces odlučivanja uslovljen velikim brojem ulaznih faktora. Ti faktori treba da omoguće fokusiranje na prioritete i ciljeve, praćenje realizacije, fleksibilnost u prevazilaženju teškoća, prilagođavanje promenama, te kontrolu nad ostvarenim rezultatima. Ovakav način upravljanja zahteva korišćenje proverenih tehnika i alata te timski rad angažovanih na projektu, kako bi se rezultati postigli u planiranom vremenu i sa planiranim sredstvima. Odgovor na ova pitanja su preko svojih metodologija pokušali da daju mnogi autori, poznati svetski instituti za upravljanje projektima, među kojima je i PMI (Project management Institute USA), čije preporuke i smernice su, u značajnoj meri, poslužile kod izrade ove disertacije. U savremenom dobu površinska eksploatacija ležišta mineralnih sirovina, usled velikog broja nepoznanica, obavlja se u sve složenijim uslovima, koje sa aspekta projektovanja, planiranja i pripreme za eksploataciju, te samog procesa odvijanja eksploatacije predstavljaju ograničavajuće faktore. Kada je reč o površinskoj eksploataciji uglja, usled niza specifičnosti koje je odlikuju, navedena problematika postaje još izraženija. Po pravilu, realizacija projekata ovog tipa, predstavlja vrlo složen proces sastavljen od višedimenzionalnih aktivnosti ispitivanja svih relevantnih determinanti budućih stanja i promena koje projekat nosi sa sobom. Sa druge strane, razvoj i nova saznanja u drugim naučnim oblastima na koje se oslanja rudarska nauka, pružaju sve šire mogućnosti njene primene.Rapid changes in the environment set numerous requirements before the managers. The aforementioned requirements are primarily related to the achievement of objectives within the given time and resources available, which requires a flexible approach to organisation of activities and efficiency in their implementation. Project management of any kind, is essentially a very complex decision-making process conditioned by a large number of input factors. Such factors should allow to focus onto the priorities and objectives, to monitor the implementation, provide flexibility in overcoming any difficulties, enable adaptation to changes and provide control over the results obtained. This management method requires the use of proven techniques and tools, as well as of teamwork involved in the project in order to achieve the results within the planned time and by using planned resources. The answer to these questions was sought and given, via various methodologies, by many authors, world-renowned project management institutes, including the PMI (Project Management Institute, USA), whose recommendations and guidelines have been used, to a significant degree, in the preparation of this dissertation. In modern times, surface mining of mineral deposits, due to the large number of unknowns, is performed in increasingly complex conditions which in terms of design, planning, mining preparation and the mining process represent the limiting factors. When it comes to surface coal mining, due to a number of specific features characterising it, the above problems become even more pronounced. As a rule, the implementation of such projects is a very complex process consisting of multidimentional testing activities of all relevant determinants of future conditions and changes that the project entails. On the other hand, the development and new knowledge in other scientific areas the mining science relies on, provide continuously expanding possibilities of its application. Taking all theabove into account, the standard approach of project management cannot fully provide for all the complexity of mining projects. Therefore, it is required..

Prediction of pH Value of Aqueous Acidic and Basic Deep Eutectic Solvent Using COSMO-RS σ Profiles’ Molecular Descriptors

The aim of this work was to develop a simple and easy-to-apply model to predict the pH values of deep eutectic solvents (DESs) over a wide range of pH values that can be used in daily work. For this purpose, the pH values of 38 different DESs were measured (ranging from 0.36 to 9.31) and mathematically interpreted. To develop mathematical models, DESs were first numerically described using σ profiles generated with the COSMOtherm software. After the DESs’ description, the following models were used: (i) multiple linear regression (MLR), (ii) piecewise linear regression (PLR), and (iii) artificial neural networks (ANNs) to link the experimental values with the descriptors. Both PLR and ANN were found to be applicable to predict the pH values of DESs with a very high goodness of fit (R2independent validation > 0.8600). Due to the good mathematical correlation of the experimental and predicted values, the σ profile generated with COSMOtherm could be used as a DES molecular descriptor for the prediction of their pH values