Trajectories of depressive symptoms after hip fracture

BACKGROUND: Hip fracture is often complicated by depressive symptoms in older adults. We sought to characterize trajectories of depressive symptoms arising after hip fracture and examine their relationship with functional outcomes and walking ability. We also investigated clinical and psychosocial predictors of these trajectories. METHOD: We enrolled 482 inpatients, aged ≥60 years, who were admitted for hip fracture repair at eight St Louis, MO area hospitals between 2008 and 2012. Participants with current depression diagnosis and/or notable cognitive impairment were excluded. Depressive symptoms and functional recovery were assessed with the Montgomery–Asberg Depression Rating Scale and Functional Recovery Score, respectively, for 52 weeks after fracture. Health, cognitive, and psychosocial variables were gathered at baseline. We modeled depressive symptoms using group-based trajectory analysis and subsequently identified correlates of trajectory group membership. RESULTS: Three trajectories emerged according to the course of depressive symptoms, which we termed ‘resilient’, ‘distressed’, and ‘depressed’. The depressed trajectory (10% of participants) experienced a persistently high level of depressive symptoms and a slower time to recover mobility than the other trajectory groups. Stressful life events prior to the fracture, current smoking, higher anxiety, less social support, antidepressant use, past depression, and type of implant predicted membership of the depressed trajectory. CONCLUSIONS: Depressive symptoms arising after hip fracture are associated with poorer functional status. Clinical and psychosocial variables predicted membership of the depression trajectory. Early identification and intervention of patients in a depressive trajectory may improve functional outcomes after hip fracture

Descripción del comportamiento de un prototipo para tratamiento electroquímico de aguas residuales industriales.

It is described in this study the behavior of a prototype of electrocoagulation as an option for industrial wastewater treatment, evaluating the efficiency of reduction of heavy metals such as zinc, nickel, chromium (total and hexavalent) and lead. The prototype is powered by waste water from galvanic and tannery industries of the city of Bogotá. The prototype was used as anode and cathode plates of iron and copper respectively, supported by copper rods to drive electricity and separated by a wooden structure (non-conductive material). The reaction is carried out in a dielectric in acrylic. The system design is based on a circuit resistive direct current (dc), where the load is represented by the effluent, resulting that the efficiency of reduction of heavy metals was 73%. According to these results, the conclusion is that the system studied can be useful in the production of clean industries.En el presente documento se realizó una descripción del proceso de electrocoagulación aplicado en aguas residuales industriales, específicamente las generadas en el sector de la galvanotecnia. Se diseñó un sistema prototipo alimentado con una muestra de aguas residuales galvánicas y de curtiembres de una empresa de la región. Evaluando la eficiencia en la reducción de metales pesados como Zinc (Zn), Níquel (Ni), Cromo (Cr) (total y hexavalente) y plomo. En el sistema se utilizaron como ánodo y cátodo placas de hierro y cobre, respectivamente, soportadas por varillas de cobre para inducir la conducción de la electricidad y separadas entre sí por una estructura en madera (material no conductor). La reacción se llevó a cabo en un recipiente dieléctrico en acrílico. El diseño se basó en un circuito resistivo de corriente directa (dc), donde la carga está representada por el afluente, obteniendo resultados que indican la eficiencia, en la reducción de metales pesados del 73%. De acuerdo con lo anterior, se puede concluir que el sistema estudiado puede ser útil en los procesos de producción más limpia para las industrias del sector

Cultivo de piña

Se tratan generalidades del cultivo de piña, su origen, zonas de producción, morfología de la planta y condiciones de suelo y clima. Adicional se contemplan la las actividades y tecnologías requeridas para establecer, mantener, cosechar y mercadear el cultivo.Generalities of pineapple cultivation, its origin, production areas, plant morphology and soil conditions and climate are treated. Additionally, the activities and technologies required to establish, maintain, harvest and market the crop are contemplated.Generalities of pineapple cultivation, its origin, production areas, plant morphology and soil conditions and climate are treated. Additionally, the activities and technologies required to establish, maintain, harvest and market the crop are contemplated.naBogot

Cuantificación de compuestos con potencial bioactivo en Citrullus lanatus, Luffa cylindrica y Sicana odorifera

La sandía vanessa, la luffa y la cassabanana son cucurbitáceas que poseen compuestos con potencial bioactivo, esto es, presencia de compuestos que ejercen efectos benéficos para la salud. En Colombia, estas frutas son desaprovechadas, debido a su escasa popularidad; dar a conocer la información de sus compuestos nutricionales incentiva su aprovechamiento y consumo. El objetivo del presente estudio fue realizar la caracterización fisicoquímica y evaluar el efecto de la liofilización y la extracción asistida por ultrasonido sobre el contenido de vitamina C, polifenoles totales y capacidad antioxidante de las partes de cada fruto. Los desechos generados entre cortezas y semillas son de 28,3 % (sandía), 68,76 % (luffa) y 25,39 % (cassabanana); estos, a su vez, presentaron contenidos de polifenoles totales y capacidad antioxidante mayores que en la pulpa. El tratamiento de liofilización mejoró la extracción % en capacidad antioxidante, vitamina C y polifenoles totales, comparado con las muestras frescas. Por otro lado, tanto la corteza como la pulpa de luffa son una buena fuente de compuestos con capacidad antioxidante, mientras que la sandía y la cassabanana alcanzaron una buena aceptación sensorial, lo cual, se atribuye al contenido de sólidos solubles y el alto contenido de agua, que las hace frutas dulces y refrescantes

Very high rotational frequencies and band termination in 73Br

Rotational bands in 73Br have been investigated up to spins of 65/2 using the EUROBALL III spectrometer. One of the negative-parity bands displays the highest rotational frequency 1.85 MeV reported to date in nuclei with mass number greater than 25. At high frequencies, the experimental dynamic moment of inertia for all bands decrease to very low values, indicating a loss of collectivity. The bands are described in the configuration-dependent cranked Nilsson-Strutinsky model. The calculations indicate that one of the negative-parity bands is observed up to its terminating single-particle state at spin 63/2. This result establishes the first band termination case in the A = 70 mass region.Comment: 6 pages, 6 figures, submitted to Phys. Rev. C as a Rapid Communicatio

Micro-tomographic characterization of the root and canal system morphology of mandibular first premolars in a Chilean population

Indexación ScopusThis study aimed to analyze the root anatomy and root canal system morphology of mandibular first premolars in a Chilean population. 186 teeth were scanned using micro-computed tomography and reconstructed three-dimensionally. The root canal system morphology was classified using both Vertucci’s and Ahmed’s criteria. The radicular grooves were categorized using the ASUDAS system, and the presence of Tomes’ anomalous root was associated with Ahmed’s score. A single root canal was identified in 65.05% of teeth, being configuration type I according to Vertucci’s criteria and code 1MP1 according to Ahmed’s criteria. Radicular grooves were observed in 39.25% of teeth. The ASUDAS scores for radicular grooves were 60.75%, 13.98%, 12.36%, 10.22%, 2.15%, and 0.54%, from grade 0 to grade 5, respectively. The presence of Tomes’ anomalous root was identified only in teeth with multiple root canals, and it was more frequently associated with code 1MP1–2 of Ahmed’s criteria. The root canal system morphology of mandibular first premolars showed a wide range of anatomical variations in the Chilean population. Teeth with multiple root canals had a higher incidence of radicular grooves, which were closely related to more complex internal anatomy. Only teeth with multiple root canals presented Tomes’ anomalous root. © 2021, The Author(s).https://www-nature-com.recursosbiblioteca.unab.cl/articles/s41598-020-80046-

Colombia's cyberinfrastructure for biodiversity: Building data infrastructure in emerging countries to foster socioeconomic growth

Science and innovation are not a luxury but a prerequisite for social and economic development (Annan, 2003)

Examining the BMI-mortality relationship using fractional polynomials

<p>Abstract</p> <p>Background</p> <p>Many previous studies estimating the relationship between body mass index (BMI) and mortality impose assumptions regarding the functional form for BMI and result in conflicting findings. This study investigated a flexible data driven modelling approach to determine the nonlinear and asymmetric functional form for BMI used to examine the relationship between mortality and obesity. This approach was then compared against other commonly used regression models.</p> <p>Methods</p> <p>This study used data from the National Health Interview Survey, between 1997 and 2000. Respondents were linked to the National Death Index with mortality follow-up through 2005. We estimated 5-year all-cause mortality for adults over age 18 using the logistic regression model adjusting for BMI, age and smoking status. All analyses were stratified by sex. The multivariable fractional polynomials (MFP) procedure was employed to determine the best fitting functional form for BMI and evaluated against the model that includes linear and quadratic terms for BMI and the model that groups BMI into standard weight status categories using a deviance difference test. Estimated BMI-mortality curves across models were then compared graphically.</p> <p>Results</p> <p>The best fitting adjustment model contained the powers -1 and -2 for BMI. The relationship between 5-year mortality and BMI when estimated using the MFP approach exhibited a J-shaped pattern for women and a U-shaped pattern for men. A deviance difference test showed a statistically significant improvement in model fit compared to other BMI functions. We found important differences between the MFP model and other commonly used models with regard to the shape and nadir of the BMI-mortality curve and mortality estimates.</p> <p>Conclusions</p> <p>The MFP approach provides a robust alternative to categorization or conventional linear-quadratic models for BMI, which limit the number of curve shapes. The approach is potentially useful in estimating the relationship between the full spectrum of BMI values and other health outcomes, or costs.</p

Intrinsic regulation of hemangioma involution by platelet-derived growth factor

Infantile hemangioma is a vascular tumor that exhibits a unique natural cycle of rapid growth followed by involution. Previously, we have shown that hemangiomas arise from CD133+ stem cells that differentiate into endothelial cells when implanted in immunodeficient mice. The same clonally expanded stem cells also produced adipocytes, thus recapitulating the involuting phase of hemangioma. In the present study, we have elucidated the intrinsic mechanisms of adipocyte differentiation using hemangioma-derived stem cells (hemSCs). We found that platelet-derived growth factor (PDGF) is elevated during the proliferating phase and may inhibit adipocyte differentiation. hemSCs expressed high levels of PDGF-B and showed sustained tyrosine phosphorylation of PDGF receptors under basal (unstimulated) conditions. Inhibition of PDGF receptor signaling caused enhanced adipogenesis in hemSCs. Furthermore, exposure of hemSCs to exogenous PDGF-BB reduced the fat content and the expression of adipocyte-specific transcription factors. We also show that these autogenous inhibitory effects are mediated by PDGF receptor-β signaling. In summary, this study identifies PDGF signaling as an intrinsic negative regulator of hemangioma involution and highlights the therapeutic potential of disrupting PDGF signaling for the treatment of hemangiomas