External bulb variable volume maser

A maser functioning as a frequency standard stable to one part in 10 to the 14th power includes a variable volume, constant surface area storage bulb having a fixed volume portion located in a resonant cavity from which the frequency standard is derived. A variable volume portion of the bulb, exterior to the resonant cavity, has a maximum volume on the same order of magnitude as the fixed volume bulb portion. The cavity has a length to radius ratio of at least 3:1 so that the operation is attained without the need for a feedback loop. A baffle plate, between the fixed and variable volume bulb portions, includes apertures for enabling hydrogen atoms to pass between the two bulb portions and is an electromagnetic shield that prevents coupling of the electromagnetic field of the cavity into the variable volume bulb portion

Detailed design of a variable volume hydrogen maser

Identification of the hydrogen maser design parameters include the shape of the bulk, q (quality parameter), tuning factors, materials to be used, and operational temperature to offset the wall shift. Expressions for the statistic error on the measured frequency were derived. Localized variations in the concentration of excited atoms were studied and how the shape of the container (the ratio of surface to volume in particular) affects their behavior

Development of an airborne laser bathymeter

An airborne laser depth sounding system was built and taken through a complete series of field tests. Two green laser sources were tried: a pulsed neon laser at 540 nm and a frequency-doubled Nd:YAG transmitter at 532 nm. To obtain a depth resolution of better than 20 cm, the pulses had a duration of 5 to 7 nanoseconds and could be fired up to at rates of 50 pulses per second. In the receiver, the signal was detected by a photomultiplier tube connected to a 28 cm diameter Cassegrainian telescope that was aimed vertically downward. Oscilloscopic traces of the signal reflected from the sea surface and the ocean floor could either be recorded by a movie camera on 35 mm film or digitized into 500 discrete channels of information and stored on magnetic tape, from which depth information could be extracted. An aerial color movie camera recorded the geographic footprint while a boat crew of oceanographers measured depth and other relevant water parameters. About two hundred hours of flight time on the NASA C-54 airplane in the area of Chincoteague, Virginia, the Chesapeake Bay, and in Key West, Florida, have yielded information on the actual operating conditions of such a system and helped to optimize the design. One can predict the maximum depth attainable in a mission by measuring the effective attenuation coefficient in flight. This quantity is four times smaller than the usual narrow beam attenuation coefficient. Several square miles of a varied underwater landscape were also mapped

Nanosecond time transfer via shuttle laser ranging experiment

A method is described to use a proposed shuttle laser ranging experiment to transfer time with nanosecond precision. All that need be added to the original experiment are low cost ground stations and an atomic clock on the shuttle. It is shown that global time transfer can be accomplished with 1 ns precision and transfer up to distances of 2000 km can be accomplished with better than 100 ps precision

Mathematical modeling of traveling-wave electroosmotic micropumps by using of the Weak Form

Abstract: Mathematical model of the AC electro-osmotic micropump based on the PoisonNernst-Planck equation, the Navier-Stokes equation and the equation of continuity has been extended by description of the microfluidic channel surroundings. This contribution is dedicated to the analysis of the preliminary results obtained from the innovated model with a new digital (discontinuous) driving mode

Ictal propagation of high frequency activity is recapitulated in interictal recordings: effective connectivity of epileptogenic networks recorded with intracranial EEG

Seizures are increasingly understood to arise from epileptogenic networks across which ictal activity is propagated and sustained. In patients undergoing invasive monitoring for epilepsy surgery, high frequency oscillations have been observed within the seizure onset zone during both ictal and interictal intervals. We hypothesized that the patterns by which high frequency activity is propagated would help elucidate epileptogenic networks and thereby identify network nodes relevant for surgical planning. Intracranial EEG recordings were analyzed with a multivariate autoregressive modeling technique (short-time direct directed transfer function--SdDTF), based on the concept of Granger causality, to estimate the directionality and intensity of propagation of high frequency activity (70-175 Hz) during ictal and interictal recordings. These analyses revealed prominent divergence and convergence of high frequency activity propagation at sites identified by epileptologists as part of the ictal onset zone. In contrast, relatively little propagation of this activity was observed among the other analyzed sites. This pattern was observed in both subdural and depth electrode recordings of patients with focal ictal onset, but not in patients with a widely distributed ictal onset. In patients with focal ictal onsets, the patterns of propagation recorded during pre-ictal (up to 5 min immediately preceding ictal onset) and interictal (more than 24h before and after seizures) intervals were very similar to those recorded during seizures. The ability to characterize epileptogenic networks from interictal recordings could have important clinical implications for epilepsy surgery planning by reducing the need for prolonged invasive monitoring to record spontaneous seizures

Electronic transport through ordered and disordered graphene grain boundaries

The evolution of electronic wave packets (WPs) through grain boundaries (GBs) of various structures in graphene was investigated by the numerical solution of the time-dependent Schrödinger equation. WPs were injected from a simulated STM tip placed above one of the grains. Electronic structure of the GBs was calculated by ab-initio and tight-binding methods. Two main factors governing the energy dependence of the transport have been identified: the misorientation angle of the two adjacent graphene grains and the atomic structure of the GB. In case of an ordered GB made of a periodic repetition of pentagon-heptagon pairs, it was found that the transport at high and low energies is mainly determined by the misorientation angle, but the transport around the Fermi energy is correlated with the electronic structure of the GB. A particular line defect with zero misorientation angle Lahiri et al., behaves as a metallic nanowire and shows electron-hole asymmetry for hot electrons or holes. To generate disordered GBs, found experimentally in CVD graphene samples, a Monte-Carlo-like procedure has been developed. Results show a reduced transport for the disordered GBs, primarily attributed to electronic localized states caused by C atoms with only two covalent bonds. © 2013 Elsevier Ltd. All rights reserved

DNM1 encephalopathy: A new disease of vesicle fission.

ObjectiveTo evaluate the phenotypic spectrum caused by mutations in dynamin 1 (DNM1), encoding the presynaptic protein DNM1, and to investigate possible genotype-phenotype correlations and predicted functional consequences based on structural modeling.MethodsWe reviewed phenotypic data of 21 patients (7 previously published) with DNM1 mutations. We compared mutation data to known functional data and undertook biomolecular modeling to assess the effect of the mutations on protein function.ResultsWe identified 19 patients with de novo mutations in DNM1 and a sibling pair who had an inherited mutation from a mosaic parent. Seven patients (33.3%) carried the recurrent p.Arg237Trp mutation. A common phenotype emerged that included severe to profound intellectual disability and muscular hypotonia in all patients and an epilepsy characterized by infantile spasms in 16 of 21 patients, frequently evolving into Lennox-Gastaut syndrome. Two patients had profound global developmental delay without seizures. In addition, we describe a single patient with normal development before the onset of a catastrophic epilepsy, consistent with febrile infection-related epilepsy syndrome at 4 years. All mutations cluster within the GTPase or middle domains, and structural modeling and existing functional data suggest a dominant-negative effect on DMN1 function.ConclusionsThe phenotypic spectrum of DNM1-related encephalopathy is relatively homogeneous, in contrast to many other genetic epilepsies. Up to one-third of patients carry the recurrent p.Arg237Trp variant, which is now one of the most common recurrent variants in epileptic encephalopathies identified to date. Given the predicted dominant-negative mechanism of this mutation, this variant presents a prime target for therapeutic intervention