An Overview of the Groundwater Use and Capacity Use Program

2010 S.C. Water Resources Conference - Science and Policy Challenges for a Sustainable Futur

Neurology

Contains reports on eight research projects.United States Air Force (AF33(616)-7588, AF49(638)-1130)National Science Foundation (Grant G-16526)United States Army Chemical Corps (DA-18-108-405-Cml-942)United States Public Health Service (B-3055, B-3090)United States Navy, Office of Naval Research (Contract Nonr-1841(70)

Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration

Aa robust inflammatory response to tissue damage and infection is conserved across almost all animal phyla. Neutrophils and macrophages, or their equivalents, are drawn to the wound site where they engulf cell and matrix debris and release signals that direct components of the repair process. This orchestrated cell migration is clinically important, and yet, to date, leukocyte chemotaxis has largely been studied in vitro. Here, we describe a genetically tractable in vivo wound model of inflammation in the Drosophila melanogaster embryo that is amenable to cinemicroscopy. For the first time, we are able to examine the roles of Rho-family small GTPases during inflammation in vivo and show that Rac-mediated lamellae are essential for hemocyte motility and Rho signaling is necessary for cells to retract from sites of matrix– and cell–cell contacts. Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

The goal of cancer immunotherapy is the generation of an effective, stable, and self-renewing antitumor T-cell population. One such approach involves the use of high-affinity cancer-specific T-cell receptors in gene-therapy protocols. Here, we present the generation of functional tumor-specific human T cells in vivo from genetically modified human hematopoietic stem cells (hHSC) using a human/mouse chimera model. Transduced hHSC expressing an HLA-A*0201–restricted melanoma-specific T-cell receptor were introduced into humanized mice, resulting in the generation of a sizeable melanoma-specific naïve CD8^+ T-cell population. Following tumor challenge, these transgenic CD8^+ T cells, in the absence of additional manipulation, limited and cleared human melanoma tumors in vivo. Furthermore, the genetically enhanced T cells underwent proper thymic selection, because we did not observe any responses against non–HLA-matched tumors, and no killing of any kind occurred in the absence of a human thymus. Finally, the transduced hHSC established long-term bone marrow engraftment. These studies present a potential therapeutic approach and an important tool to understand better and to optimize the human immune response to melanoma and, potentially, to other types of cancer

The Grizzly, May 4, 1984

Sir Thomson to Speak at Commencement • Changes to Take Place in Student Life Office • Yatsko Wins Fellowship • UC Hosts USWLA Championship • Professor with the Quiet Manner: George Storey Retires From English • UC Students Attend Model UN • Chamber Groups to Perform • Work Snarls Traffic on Bridge • A Legend Retires as Pancoast Leaves • Union Pub a Hit • Solution for a Printing Crisis • Letters to the Editor: Suggestions for Social Life • Standeven Wins Chemistry Award • \u2784 Ruby Orders Being Taken Now • Play Simon Sez With Bobby Gold • 3 Seniors Land Top Accounting Jobs • Post Graduation Plans for Class of 1984 • Tursi Goes to Scotland • UC Discovers Charm of Trivial Pursuit • Language Honor Society Forms Local Chapter • Richter Announces Death of Dr. Rice • Students Debate Deployment of Missiles • Ursinus, A Well Kept Secret • Forum Relieves Tension • Shiatsu Cures Stress • UC Poet Writes About Amish • Final Exam Schedule Posted • Men\u27s Lacrosse Reaches Turning Point • Men\u27s Tennis Beats Wilkes, Loses to Mules • Greek Week Reveals Student Spirit • Gasser Named New Basketball Coach • Men\u27s Track Wins 2, Drop 1 for 7-3 Record • UC Fencers Place in Tournament • Softball at 14-3 • UC Field Hockey to Visit Europe • Jamison Breaks Recordhttps://digitalcommons.ursinus.edu/grizzlynews/1118/thumbnail.jp

Early cancer detection among rural and urban californians

BACKGROUND: Since the stage of cancer detection generally predicts future mortality rates, a key cancer control strategy is to increase the proportion of cancers found in the early stage. This study compared stage of detection for members of rural and urban communities to determine whether disparities were present. METHODS: The California Cancer Registry (CCR), a total population based cancer registry, was used to examine the proportion of early stage presentation for patients with breast, melanoma, and colon cancer from 1988 to 2003. Cancer stage at time of detection for these cancers was compared for rural and urban areas. RESULTS: In patients with breast cancer, there were significantly more patients presenting at early stage in 2003 compared to 1988, but no difference in the percentage of patients presenting with early stage disease between rural and urban dwellers. There were no differences in incidence in early stage cancer incidence between these groups for melanoma patients, as well. In colorectal cancer in 1988, significantly more patients presented with early stage disease in the urban areas (42% vs 34%, p < 0.02). However, over time the rural patients were diagnosed with early stage disease with the same frequency in 2003 as 1988. CONCLUSION: This analysis demonstrates that people in rural and urban areas have their breast, melanoma or colorectal cancers diagnosed at similar stages. Health care administrators may take this information into account in future strategic planning