307 research outputs found
Z prawem na ty
S\u142owa kluczowe: dydaktyka prawa; teoria pa\u144stwa i prawa; filozofia prawa; poradniki dla nauczycieli \u2013 prawo; podstawy praw
Analytic Surgery of the zeta-determinant of the Dirac operator
We review the work of the authors and their collaborators on the
decomposition of the zeta-determinant of the Dirac operator into the
contribution coming from different parts of a manifold.Comment: final versio
General Spectral Flow Formula for Fixed Maximal Domain
We consider a continuous curve of linear elliptic formally self-adjoint
differential operators of first order with smooth coefficients over a compact
Riemannian manifold with boundary together with a continuous curve of global
elliptic boundary value problems. We express the spectral flow of the resulting
continuous family of (unbounded) self-adjoint Fredholm operators in terms of
the Maslov index of two related curves of Lagrangian spaces. One curve is given
by the varying domains, the other by the Cauchy data spaces. We provide
rigorous definitions of the underlying concepts of spectral theory and
symplectic analysis and give a full (and surprisingly short) proof of our
General Spectral Flow Formula for the case of fixed maximal domain. As a side
result, we establish local stability of weak inner unique continuation property
(UCP) and explain its role for parameter dependent spectral theory.Comment: 22 page
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Novel PI3KÎł Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain
A 44-year-old man is presented here with 14 years of chronic purulent sinusitis, a chronic fungal rash of the scrotum, and chronic pelvic pain. Treatment with antifungal therapy resulted in symptom improvement, however he was unable to establish an effective long-term treatment regimen, resulting in debilitating symptoms. He had undergone extensive work-up without identifying a clear underlying etiology, although Candida species were cultured from the prostatic fluid. 100 genes involved in the cellular immune response were sequenced and a missense mutation was identified in the Ras-binding domain of PI3KÎł. PI3KÎł is a crucial signaling element in leukotaxis and other leukocyte functions. We hypothesize that his mutation led to his chronic infections and pelvic pain
Mass-spectrometric studies of new 6-nitroquipazines—serotonin transporter inhibitors
Six synthesized 6-nitroquipazine derivatives were examined by electron ionization (EI) and electrospray ionization (ESI) mass spectrometry in positive and negative ion mode. The compounds exhibit high affinity for the serotonin transporter (SERT) and belong to a new class of SERT inhibitors. The EI mass spectra registered in negative ion mode showed prominent molecular ions for all the compounds studied. All EI mass spectra and all ESI mass spectra showed similar fragmentation pathways of molecular ions, but the pathways differed between EI and ESI. The differences were explained with the aid of theoretical evaluation of the stability of the respective radical ions (EI MS) and protonated ions (ESI MS)
The stability for the Cauchy problem for elliptic equations
We discuss the ill-posed Cauchy problem for elliptic equations, which is
pervasive in inverse boundary value problems modeled by elliptic equations. We
provide essentially optimal stability results, in wide generality and under
substantially minimal assumptions. As a general scheme in our arguments, we
show that all such stability results can be derived by the use of a single
building brick, the three-spheres inequality.Comment: 57 pages, review articl
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