Computed tomography angiography for the interventional cardiologist

WOS:000339902400002In recent years, coronary CT angiography (CCTA) has become a widely adopted technique, not only due to its high diagnostic accuracy, but also to the fact that CCTA provides a comprehensive evaluation of the total (obstructive and non-obstructive) coronary atherosclerotic burden. More recently, this technique has become mature, with a large body of evidence addressing its prognostic validation. In addition, CT angiography has moved from the field of `imagers' and clinicians and entered the interventional cardiology arena, aiding in the planning of both coronary and structural heart interventions, being transcatheter aortic valve implantation one of its most successful examples. It is therefore of utmost importance that interventional cardiologists become familiar with image interpretation and up-to-date regarding several CTA features, taking advantage of this information in planning the procedure, ultimately leading to improvement in patient outcomes. On the other hand, the increasing use of CCTA as a gatekeeper for invasive coronary angiography is expected to lead to an increase in the ratio of interventional to diagnostic procedures and significant changes in the daily cath-lab routine. In a foreseeable future, cath-labs will probably offer an invasive procedure only to patients expected to undergo an intervention, perhaps becoming in this change true interventional-labs.publishersversionpublishe

Ordenamento ambiental e época de plantio da mamoneira (Ricinus communis L.) para a região Norte de Minas Gerais.

Ordenamento ambiental e época de plantio da mamoneirabitstream/CNPA/19621/1/COMTEC207.PD

Encapsulation of clove oil in nanostructured lipid carriers from natural waxes: Preparation, characterization and in vitro evaluation of the cholinesterase enzymes

Eugenol is a phenolic compound largely found in the clove essential oil that possesses promising biological activity. However, its low water solubility is a major concern and encapsulation is an alternative to improve water affinity. The objective of this work was to produce nanostructured lipid carriers (NLC) by hot homogenization/ultrasound emulsification and to evaluate the effect of free and encapsulated clove oil on the in vitro cholinesterase enzymes modulation using Drosophila melanogaster (DM) tissue. The NLC composed of a natural wax (carnauba or beeswax) and crodamol showed an average diameter between 121 and 367 nm with good dispersion and colloidal stability. The spherical shape and solid character together with the semi-crystalline environment confirm the formation of NLC. DSC analysis indicated polymorphic transition events of the waxes. In vitro tests using DM demonstrated that free clove oil showed a good inhibition of the butyryl and acetylcholinesterase enzymes above a concentration of 10 mM, with IC50 values of 4.3 and 3.5 mM, respectively. The dispersions of the NLC loaded with clove oil showed a decrease in the IC50 enzymes values, indicating the preservation of the clove essential oil and suggesting an increased in the solubility. Results indicate that NLC dispersions have good potential to be used for foods and cosmetic aqueous formulations possessing biological activity.Authors thank the financial support from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), and also Laboratório Central de Microscopia Eletrônica of Universidade Federal de Santa Catarina (LCME/UFSC) for TEM analyses.info:eu-repo/semantics/publishedVersio

Fungo micorrízico de orquídea na biofertilização de plantas de arroz em casa de vegetação.

Objetivou-se testar o efeito de um fungo micorrízico de orquídea no crescimento de plantas de arroz.Fertbio 2016

Photoprotector adjuvants to enhance UV tolerance of yeast strains for controlling mango decay using pre-harvest spraying.

Post-harvest mango decay is caused by multiple pathogens in tropical conditions but concerns regarding the risk of food contamination by fungicides established biocontrol as a promising alternative. However, occurrence of quiescent infections requires pre-harvest applications of biocontrol agents (BCA), exposing them to harmful UV radiation effects. The objective of this work was to evaluate UV sensitivity of yeast BCA strains previously selected against multiple pathogens that cause mango decay and evaluate suitable UV protectants. In a first bioassay conducted exposing yeast suspensions sprayed on glass plates, it was verified that Saccharomyces sp. ESA47 and Pichia kudriavzevii CMIAT171 were highly sensitive to UV, while Saccharomyces cerevisiae ESA45 had a slightly lower mortality. A bioassay using fragments of mango peels evaluated UV protection from increasing concentrations of starch, dextrin, casein, benzophenone, and cinnamic acid derivative compounds. Results showed that starch and isoamyl p-methoxycinnamate (NHE-1000) resulted in higher survival for yeast strains in doses of 10.0 and 1.0 g kg−1, respectively. Application of the yeast BCA in a semi-commercial mango orchard resulted in a significant reduction of post-harvest disease incidence and severity. Field application of the yeasts in technical grade preparations containing both UV protectants enhanced the control efficiency by 52.5, 31.9, and 37.7% for ESA45, ESA47, and CMIAT171, respectively

Microbiolização de sementes de arroz com microrganismos benéficos.

Neste trabalho verificou-se o desempenho das plantas de arroz na germinação e no desenvolvimento inicial das plântulas in vitro usando microrganismos, fungos endofíticos e bactérias do solo.Fertbio 2016

Prevalence and predictors of coronary artery disease in patients with a calcium score of zero

The absence of coronary calcification is associated with an excellent prognosis. However, a calcium score of zero does not exclude the presence of coronary artery disease (CAD) or the possibility of future cardiovascular events. Our aim was to study the prevalence and predictors of coronary artery disease in patients with a calcium score of zero. Prospective registry consisted of 3,012 consecutive patients that underwent cardiac CT (dual source CT). Stable patients referred for evaluation of possible CAD that had a calcium score of zero (n = 864) were selected for this analysis. The variables that were statistically significant were included in a multivariable logistic regression model. From 864 patients with a calcium score of zero, 107 (12.4 %) had coronary plaques on the contrast CT (10.8 %, n = 93 with nonobstructive CAD and 1.6 %, n = 14 with obstructive CAD). By logistic regression analysis, the independent predictors of CAD in this population were age >55 years [odds ratio (OR) 1.63 (1.05-2.52)], hypertension [OR 1.64 (1.05-2.56)] and dyslipidemia [OR 1.54 (1.00-2.36)]. In the presence of these 3 variables, the probability of having coronary plaques was 21 %. The absence of coronary artery calcification does not exclude the presence of coron

Nanotecnologia e Nanociência no Ensino de Química

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