169 research outputs found
Using WWW to improve software development and maintenance: application of the LIGHT system to ALEPH programs
Programmers who develop, use, maintain, modify software and faced with the problem of scanning and understanding large amounts of documents, ranging from source code to requirements, analysis and design diagrams, user and reference manuals etc. This task is non trivial and time consuming LIGHT, LIfe cycle Global HyperText is an attempt to solve the problem using WWW technology. The basic idea is to make all the software documents, including code, available and cross-connected on the WWW. The first application of this concept to go in production is JULIA?LIGHT, a system to convert and publish on WWW the software documentation of the JULIA reconstruction program of the ALEPH experiment at CERN European Organisation for Particle Physics, Geneva
Lunar laser ranging in infrfared at hte Grasse laser station
For many years, lunar laser ranging (LLR) observations using a green
wavelength have suffered an inhomogeneity problem both temporally and
spatially. This paper reports on the implementation of a new infrared detection
at the Grasse LLR station and describes how infrared telemetry improves this
situation. Our first results show that infrared detection permits us to densify
the observations and allows measurements during the new and the full Moon
periods. The link budget improvement leads to homogeneous telemetric
measurements on each lunar retro-reflector. Finally, a surprising result is
obtained on the Lunokhod 2 array which attains the same efficiency as Lunokhod
1 with an infrared laser link, although those two targets exhibit a
differential efficiency of six with a green laser link
In vivo magnetic resonance spectroscopy in the brain of Cdkl5 null mice reveals a metabolic profile indicative of mitochondrial dysfunctions
Mutations in the X‐linked CDKL5 gene cause CDKL5 deficiency disorder (CDD), a severe neurodevelopmental condition mainly characterized by infantile epileptic encephalopathy, intellectual disability, and autistic features. The molecular mechanisms underlying the clinical symptoms remain largely unknown and the identification of reliable biomarkers in animal models will certainly contribute to increase our comprehension of CDD as well as to assess the efficacy of therapeutic strategies. Here, we used different Magnetic Resonance (MR) methods to disclose structural, functional, or metabolic signatures of Cdkl5 deficiency in the brain of adult mice. We found that loss of Cdkl5 does not cause cerebral atrophy but affects distinct brain areas, particularly the hippocampus. By in vivo proton‐MR spectroscopy (MRS), we revealed in the Cdkl5 null brain a metabolic dysregulation indicative of mitochondrial dysfunctions. Accordingly, we unveiled a significant reduction in ATP levels and a decrease in the expression of complex IV of mitochondrial electron transport chain. Conversely, the number of mitochondria appeared preserved. Importantly, we reported a significant defect in the activation of one of the major regulators of cellular energy balance, the adenosine monophosphate‐activated protein kinase (AMPK), that might contribute to the observed metabolic impairment and become an interesting therapeutic target for future preclinical trials. In conclusion, MRS revealed in the Cdkl5 null brain the presence of a metabolic dysregulation suggestive of a mitochondrial dysfunction that permitted to foster our comprehension of Cdkl5 deficiency and brought our interest towards targeting mitochondria as therapeutic strategy for CDD
Stronger diversity effects with increased environmental stress : a study of multitrophic interactions between oak, powdery mildew and ladybirds
Recent research has suggested that increasing neighbourhood tree species diversity may mitigate the impact of pests or pathogens by supporting the activities of their natural enemies and/or reducing the density of available hosts. In this study, we attempted to assess these mechanisms in a multitrophic study system of young oak (Quercus), oak powdery mildew (PM, caused by Erysiphe spp.) and a mycophagous ladybird (Psyllobora vigintiduo-punctata). We assessed ladybird mycophagy on oak PM in function of different neighbourhood tree species compositions. We also evaluated whether these species interactions were modulated by environmental conditions as suggested by the Stress Gradient Hypothesis. We adopted a complementary approach of a field experiment where we monitored oak saplings subjected to a reduced rainfall gradient in a young planted forest consisting of different tree species mixtures, as well as a lab experiment where we independently evaluated the effect of different watering treatments on PM infections and ladybird mycophagy. In the field experiment, we found effects of neighbourhood tree species richness on ladybird mycophagy becoming more positive as the target trees received less water. This effect was only found as weather conditions grew drier. In the lab experiment, we found a preference of ladybirds to graze on infected leaves from trees that received less water. We discuss potential mechanisms that might explain this preference, such as emissions of volatile leaf chemicals. Our results are in line with the expectations of the Natural Enemies Hypothesis and support the hypothesis that biodiversity effects become stronger with increased environmental stress
Modal Virtue Epistemology
10.1111/phpr.12562Philosophy and Phenomenological Researc
Using the motion of S2 to constrain vector clouds around SgrA*
The dark compact object at the centre of the Milky Way is well established to
be a supermassive black hole with mass , but the nature of its environment is still under debate. In this
work, we used astrometric and spectroscopic measurements of the motion of the
star S2, one of the closest stars to the massive black hole, to determine an
upper limit on an extended mass composed of a massive vector field around
Sagittarius A*. For a vector with effective mass , our Markov Chain Monte Carlo analysis shows
no evidence for such a cloud, placing an upper bound at confidence level. We show that dynamical
friction exerted by the medium on S2 motion plays no role in the analysis
performed in this and previous works, and can be neglected thus.Comment: 9 pages, 5 figures, accepted to MNRA
Polarimetry and Astrometry of NIR Flares as Event Horizon Scale, Dynamical Probes for the Mass of Sgr A*
We present new astrometric and polarimetric observations of flares from Sgr
A* obtained with GRAVITY, the near-infrared interferometer at ESO's Very Large
Telescope Interferometer (VLTI), bringing the total sample of well-covered
astrometric flares to four and polarimetric ones to six, where we have for two
flares good coverage in both domains. All astrometric flares show clockwise
motion in the plane of the sky with a period of around an hour, and the
polarization vector rotates by one full loop in the same time. Given the
apparent similarities of the flares, we present a common fit, taking into
account the absence of strong Doppler boosting peaks in the light curves and
the EHT-measured geometry. Our results are consistent with and significantly
strengthen our model from 2018: We find that a) the combination of polarization
period and measured flare radius of around nine gravitational radii (, innermost stable circular orbit) is consistent with
Keplerian orbital motion of hot spots in the innermost accretion zone. The mass
inside the flares' radius is consistent with the measured from stellar orbits at several thousand . This
finding and the diameter of the millimeter shadow of Sgr A* thus support a
single black hole model. Further, b) the magnetic field configuration is
predominantly poloidal (vertical), and the flares' orbital plane has a moderate
inclination with respect to the plane of the sky, as shown by the non-detection
of Doppler-boosting and the fact that we observe one polarization loop per
astrometric loop. Moreover, c) both the position angle on sky and the required
magnetic field strength suggest that the accretion flow is fueled and
controlled by the winds of the massive, young stars of the clockwise stellar
disk 1-5 arcsec from Sgr A*, in agreement with recent simulations.Comment: 10 pages, 12 figures. Submitted to A&
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