A numerical ocean circulation model of the Norwegian and Greenland Seas

The dynamics and thermodynamics of the Norwegian and Greenland Seas are investigated using a three-dimensional primitive equation ocean circulation model. The horizontal resolution of the model is 1° in the zonal direction and 0.5° in the meridional direction. The vertical structure is described by 15 levels. The model is driven by both annual mean and seasonally varying wind and thermohaline forcing. The connections of the Norwegian and Greenland Seas with the North Atlantic and Arctic Ocean are modelled with an open boundary condition. The simulated currents are in reasonable agreement with the observed circulation

Adverse drug reactions from psychotropic medicines in the paediatric population: analysis of reports to the Danish Medicines Agency over a decade

<p>Abstract</p> <p>Background</p> <p>The prescribing of psychotropic medicines for the paediatric population is rapidly increasing. In attempts to curb the use of psychotropic medicine in the paediatric population, regulatory authorities have issued various warnings about risks associated with use of these products in childhood. Little evidence has been reported about the adverse drug reactions (ADRs) of these medicines in practice. As spontaneous reports are the main source for information about previously unknown ADRs, we analysed data submitted to a national ADR database. The objective was to characterise ADRs reported for psychotropic medicines in the Danish paediatric population over a decade.</p> <p>Findings</p> <p>All spontaneous ADR reports from 1998 to 2007 for children from birth to 17 years of age were included. The unit of analysis was one ADR. We analysed the distribution of ADRs per year, seriousness, age and gender of the child, suspected medicine and type of reported ADR. A total of 429 ADRs were reported for psychotropic medicines and 56% of these were classified as serious. Almost 20% of psychotropic ADRs were reported for children from birth up to 2 years of age and one half of ADRs were reported in adolescents, especially for antidepressants and psychostimulants. Approximately 60% of ADRs were reported for boys. Forty percent of all ADRs were from the category 'nervous and psychiatric disorders'. All but one ADR reported for children below two years were serious and two of these were fatal. A number of serious ADRs reported in children from birth up to 2 years of age were presumably caused by mothers' use of psychotropic medicines during pregnancy.</p> <p>Conclusion</p> <p>The high number of serious ADRs reported for psychotropic medicines in the paediatric population should be a concern for health care professionals and physicians. Considering the higher number of birth defects being reported greater care has to be given while prescribing these drugs for pregnant women.</p

Classification of Minimal Separating Sets of Low Genus Surfaces

A minimal separating set in a connected topological space $X$ is a subset $L \subset X$ with the property that $X \setminus L$ is disconnected, but if $L^{\prime}$ is a proper subset of $L$, then $X \setminus L^{\prime}$ is connected. Such sets show up in a variety of contexts. For example, in a wide class of metric spaces, if we choose distinct points p and q, then the set of points x satisfying d(x, p) = d(x, q) is a minimal separating set. In this paper we classify which topological graphs can be realized as minimal separating sets in surfaces of low genus. In general the question of whether a graph can be embedded at all in a surface is a difficult one, so our work is partly computational. We classify graphs embeddings which are minimal separating in a given genus and write a computer program to find all such embeddings and their underlying graphs.Comment: 19 pages, 6 figure

Numerical modeling including hysteresis properties for CO2 storage in Tubåen formation, Snøhvit field, Barents Sea

AbstractIn April 2008 the first injection of supercritical CO2 started into the Tubåen Formation from the Snøhvit field, Barents Sea. At full capacity, the plan is to inject approximately 23 Mtons of CO2 via one well during a 30 year period. The aim of this study was to simulation the 30 years of injection of supercritical CO2 and the following long term (5000 years) storage of CO2 in the Tubåen formation. The formation is at approximately 2600 meters depth and is at 98 °C and 265 bars. The simulations suggested that, because of limited lateral permeability, the bottom hole pressure increases rapidly to more than 800 bars if an annual injection rate of 766000 tons is used. This is significantly higher than the fracture pressures for the formation, and it is therefore suggested that the aim to inject 23 Mtons over the planed 30 years may be unrealistic. To prevent fracturing due to increasing pressure, the bottom hole pressure constraint is applied that leads to significant decrease in the amount of CO2 injected. With the hysteresis property applied, reservoir pressure behavior is the same in the base case (no hysteresis); however, the CO2 plume is distributed over a smaller area than in the base case. Similar to the case of hysteresis, the diffusion flow case shows the CO2 plume to be distributed over a smaller area than in the base case, but reservoir pressure decreases more than in the other two cases