Swiss Biotech – An Overview of the Industry and the Key Stakeholders 2010

This article presents the stakeholders of the Swiss Biotechnology sector. From academia to industry, from TechTransfer initiatives to state impulse programs, the sector has developed rapidly in the last years. Public Private Partnerships such as Life Science Clusters and collaborations between industry associations have proven to be an essential part for sustainable success for our national GDP. The author has extensive experience in the various sub-sectors

Shell to shell energy transfer in MHD, Part II: Kinematic dynamo

We study the transfer of energy between different scales for forced three-dimensional MHD turbulent flows in the kinematic dynamo regime. Two different forces are examined: a non-helical Taylor Green flow with magnetic Prandtl number P_M=0.4, and a helical ABC flow with P_M=1. This analysis allows us to examine which scales of the velocity flow are responsible for dynamo action, and identify which scales of the magnetic field receive energy directly from the velocity field and which scales receive magnetic energy through the cascade of the magnetic field from large to small scales. Our results show that the turbulent velocity fluctuations are responsible for the magnetic field amplification in the small scales (small scale dynamo) while the large scale field is amplified mostly due to the large scale flow. A direct cascade of the magnetic field energy from large to small scales is also present and is a complementary mechanism for the increase of the magnetic field in the small scales. Input of energy from the velocity field in the small magnetic scales dominates over the energy that is cascaded down from the large scales until the large-scale peak of the magnetic energy spectrum is reached. At even smaller scales, most of the magnetic energy input is from the cascading process.Comment: Submitted to PR

Marginally unstable Holmboe modes

Marginally unstable Holmboe modes for smooth density and velocity profiles are studied. For a large family of flows and stratification that exhibit Holmboe instability, we show that the modes with phase velocity equal to the maximum or the minimum velocity of the shear are marginally unstable. This allows us to determine the critical value of the control parameter R (expressing the ratio of the velocity variation length scale to the density variation length scale) that Holmboe instability appears R=2. We then examine systems for which the parameter R is very close to this critical value. For this case we derive an analytical expression for the dispersion relation of the complex phase speed c(k) in the unstable region. The growth rate and the width of the region of unstable wave numbers has a very strong (exponential) dependence on the deviation of R from the critical value. Two specific examples are examined and the implications of the results are discussed.Comment: Submitted to Physics of Fluid

Shell to shell energy transfer in MHD, Part I: steady state turbulence

We investigate the transfer of energy from large scales to small scales in fully developed forced three-dimensional MHD-turbulence by analyzing the results of direct numerical simulations in the absence of an externally imposed uniform magnetic field. Our results show that the transfer of kinetic energy from the large scales to kinetic energy at smaller scales, and the transfer of magnetic energy from the large scales to magnetic energy at smaller scales, are local, as is also found in the case of neutral fluids, and in a way that is compatible with Kolmogorov (1941) theory of turbulence. However, the transfer of energy from the velocity field to the magnetic field is a highly non-local process in Fourier space. Energy from the velocity field at large scales can be transfered directly into small scale magnetic fields without the participation of intermediate scales. Some implications of our results to MHD turbulence modeling are also discussed.Comment: Submitted to PR

Stratified shear flow instabilities at large Richardson numbers

Numerical simulations of stratified shear flow instabilities are performed in two dimensions in the Boussinesq limit. The density variation length scale is chosen to be four times smaller than the velocity variation length scale so that Holmboe or Kelvin-Helmholtz unstable modes are present depending on the choice of the global Richardson number Ri. Three different values of Ri were examined Ri =0.2, 2, 20. The flows for the three examined values are all unstable due to different modes namely: the Kelvin-Helmholtz mode for Ri=0.2, the first Holmboe mode for Ri=2, and the second Holmboe mode for Ri=20 that has been discovered recently and it is the first time that it is examined in the non-linear stage. It is found that the amplitude of the velocity perturbation of the second Holmboe mode at the non-linear stage is smaller but comparable to first Holmboe mode. The increase of the potential energy however due to the second Holmboe modes is greater than that of the first mode. The Kelvin-Helmholtz mode is larger by two orders of magnitude in kinetic energy than the Holmboe modes and about ten times larger in potential energy than the Holmboe modes. The results in this paper suggest that although mixing is suppressed at large Richardson numbers it is not negligible, and turbulent mixing processes in strongly stratified environments can not be excluded.Comment: Submitted to Physics of Fluid

The imprint of large-scale flows on turbulence

We investigate the locality of interactions in hydrodynamic turbulence using data from a direct numerical simulation on a grid of 1024^3 points; the flow is forced with the Taylor-Green vortex. An inertial range for the energy is obtained in which the flux is constant and the spectrum follows an approximate Kolmogorov law. Nonlinear triadic interactions are dominated by their non-local components, involving widely separated scales. The resulting nonlinear transfer itself is local at each scale but the step in the energy cascade is independent of that scale and directly related to the integral scale of the flow. Interactions with large scales represent 20% of the total energy flux. Possible explanations for the deviation from self-similar models, the link between these findings and intermittency, and their consequences for modeling of turbulent flows are briefly discussed

Water waves over a time-dependent bottom: Exact description for 2D potential flows

Two-dimensional potential flows of an ideal fluid with a free surface are considered in situations when shape of the bottom depends on time due to external reasons. Exact nonlinear equations describing surface waves in terms of the so called conformal variables are derived for an arbitrary time-evolving bottom parameterized by an analytical function. An efficient numerical method for the obtained equations is suggested.Comment: revtex4, 7 pages, 19 EPS figures; corrected version with more numerical result

Effects of anisotropy in geostrophic turbulence

The Boussinesq model of convection in a flat layer with heating from below is considered. We analyze the effects of anisotropy caused by rapid rotation in physical and wave spaces and demonstrate the suppression of energy transfer by rotation. We also examine the structure of the wave triangle in nonlinear interaction. The range of parameters is adapted to the models of convection in the geodynamo

Non-local interactions in hydrodynamic turbulence at high Reynolds numbers: the slow emergence of scaling laws

We analyze the data stemming from a forced incompressible hydrodynamic simulation on a grid of 2048^3 regularly spaced points, with a Taylor Reynolds number of Re~1300. The forcing is given by the Taylor-Green flow, which shares similarities with the flow in several laboratory experiments, and the computation is run for ten turnover times in the turbulent steady state. At this Reynolds number the anisotropic large scale flow pattern, the inertial range, the bottleneck, and the dissipative range are clearly visible, thus providing a good test case for the study of turbulence as it appears in nature. Triadic interactions, the locality of energy fluxes, and structure functions of the velocity increments are computed. A comparison with runs at lower Reynolds numbers is performed, and shows the emergence of scaling laws for the relative amplitude of local and non-local interactions in spectral space. The scalings of the Kolmogorov constant, and of skewness and flatness of velocity increments, performed as well and are consistent with previous experimental results. Furthermore, the accumulation of energy in the small-scales associated with the bottleneck seems to occur on a span of wavenumbers that is independent of the Reynolds number, possibly ruling out an inertial range explanation for it. Finally, intermittency exponents seem to depart from standard models at high Re, leaving the interpretation of intermittency an open problem.Comment: 8 pages, 8 figure

Phase transitions and flux-loop metastable states in rotating turbulence

By using direct numerical simulations of up to a record resolution of 512x512x32768 grid points we discover the existence of a new metastable out-of-equilibrium state in rotating turbulence. We scan the phase space by varying both the rotation rate (proportional to the inverse of the Rossby number, $Ro$) and the dimensionless aspect ratio, $\lambda=H/L$, where $L$ and $H$ are the sizes of the domain perpendicular and parallel to the direction of rotation, respectively. We show the existence of three turbulent phases. For small $Ro$ but finite $\lambda$, we have a split cascade where the injected energy is transferred to both large and small scales. For large $\lambda$ and finite $Ro$ there is no inverse cascade and the energy is transferred forward in Fourier space only. Surprisingly, between these two regimes, a third phase is observed as reported here for the first time. Consequently, for certain intervals of $Ro$ and $\lambda$, energy is no longer accumulated at arbitrarily large scales, rather it stops at some characteristic intermediate length-scales from where it is then redistributed forward in Fourier space, leading to a flux-loop mechanism where the flow is out of equilibrium with vanishing net flux, and non-vanishing heterochiral and homochiral sub-fluxes. The system is further characterized by the presence of metastability and critical slowing down, explaining why previous experiments and numerical simulations were not able to detect this phenomenon, requiring extremely long observation time and huge computational resources