272 research outputs found
Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains
AbstractThe C57BLKS/J (BKS) inbred mouse strain is a widely used animal model of type 2 diabetes. In the presence of the diabetes (db) mutation, obese BKS-db mice develop severe diabetes. Genetic studies of diabetes-susceptibility in this strain are facilitated by the fact that BKS is a genetic composite between the diabetes-resistant C57BL/6J (B6) and susceptible DBA/2J (DBA) strains. On this basis, it has been hypothesized that diabetes-susceptibility in BKS is conferred by DBA-derived alleles. However, recent studies revealed non-B6/non-DBA genetic material in BKS. To identify the origin of this genetic component, we generated a genomic map of BKS using 537 microsatellite markers. Our results demonstrate that, in addition to B6 and DBA, BKS contains alleles from at least three other strains, including 129, C57BL/10 and an unidentified mouse strain. We also analyzed two congenic strains, B6-db and BKS-db, which are widely used for the genetic mapping of diabetes-susceptibility loci. We identified several donor-derived genomic regions introduced during the generation of these congenic strains. In summary, our study reveals novel aspects of the genetic fine-structure of BKS and related strains and facilitates the identification of diabetes-susceptibility loci in this mouse model
Operåciókutatåsi feladat megoldåsa sajåt fejlesztésû Borland
Operåciókutatåsi feladat megoldåsa sajåt fejlesztésû Borland
Delphi program Ă©s Lingo dll segĂtsĂ©gĂ©velB
Kalauz a siketnémåk oktatåsa és nevelése terén 04 (1891) 05-06
Kalauz 04. Ă©vfolyam, 5-6. szĂĄm VĂĄc, 1891. januĂĄr. A testi Ă©s szellemi fogyatkozĂĄsban szenvedĆket gyĂĄmolĂtĂł orszĂĄgos egyesĂŒlet hivatalos közlönye. A folyĂłirat 1896-97. Ă©vtĆl Ășj cĂmen, "Kalauz az emberbarĂĄti oktatĂĄs Ă©s nevelĂ©s terĂ©n" cĂm alatt jelent meg
Magyar TanĂtĂłkĂ©pzĆ 7 (1892) EmlĂ©kirat
Magyar TanĂtĂłkĂ©pzĆ
A TanĂtĂłkĂ©pzĆ-intĂ©zeti TanĂĄrok OrszĂĄgos EgyesĂŒletĂ©nek II. emlĂ©kirata GrĂłf CsĂĄky Albin vallĂĄs- Ă©s közoktatĂĄsĂŒgyi magy. kir. miniszter Ășr Ć nagymĂ©ltĂłsĂĄgĂĄhoz
FelterjesztĂ© az egyesĂŒlet vĂĄlasztmĂĄny
MellĂ©klet a "Magyar TanĂtĂłkĂ©pzĆ" VI. Ă©vfolyam, 2. szĂĄmĂĄhoz
MellĂ©klet a Magyar TanĂtĂłkĂ©pzĆ VI. Ă©vfolyam, 2. szĂĄmĂĄhoz
A TanĂtĂłkĂ©pzĆ-intĂ©zeti tanĂĄrok OrszĂĄgos EgyesĂŒletĂ©nek emlĂ©kirata
Az 1890. évi augusztus 18.- és 19.-én tartott közgyƱlés hatårozatai
A IV. egyetemes tanĂtĂłgyƱlĂ©ssel kapcsolatos munkĂĄlat
GrĂłf CsĂĄky Albin vallĂĄs- Ă©s közoktatĂĄsĂŒgyi magy. kir. miniszter Ășr Ć nagymĂ©ltĂłsĂĄgĂĄhoz
FelterjesztĂ©: az EgyesĂŒlet vĂĄlasztmĂĄny
Rhodococcus equi ĂĄltal okozott nagyĂzĂŒleti endoprotĂ©zis körĂŒl kialakult fertĆzĂ©s
Rhodococcus equi is a rare pathogen in humans causing infections mostly in immunocompromised hosts. We present the first case of periprosthetic joint infection caused by Rhodococcus equi. An 88-year-old male patient was referred to our clinic with a history of fever and right hip pain. The patient had multiple hip surgeries including total joint arthroplasty and revision for aseptic loosening on the right side. He was immunocompetent, but his additional medical history was remarkable for diabetes mellitus, diabetic nephropathy and stroke with hemiplegia resulting in immobilization. Radiography showed stable components, joint aspirate yielded Rhodococcus equi. Irrigation and debridement was proposed, but the patient refused any surgical intervention. Therefore antibiotic therapy was administered. At the last follow-up the patient is free of complaints but the C-reactive protein level is still elevated. This case illustrates the possible role of Rhodococcus equi in medical device-associated infections. Orv Hetil. 2017; 158(27): 1071-1074
Magyar TanĂtĂłkĂ©pzĆ 7 (1892) 09
Magyar TanĂtĂłkĂ©pzĆ
A TanĂtĂłkĂ©pzĆ-intĂ©zeti TanĂĄrok OrszĂĄgos EgyesĂŒletĂ©nek közlönye
7. Ă©vfolyam, 9. fĂŒzet
Budapest, 1892. november h
Magyar TanĂtĂłkĂ©pzĆ 6 (1891) 06
Magyar TanĂtĂłkĂ©pzĆ
A TanĂtĂłkĂ©pzĆ-intĂ©zeti TanĂĄrok OrszĂĄgos EgyesĂŒletĂ©nek közlönye
6. Ă©vfolyam, VI. fĂŒzet
Budapest, 1891. jĂșnius 25
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