Estudio descriptivo de tablas-control de usuarios de mejora de los aspectos cualitativos de la calidad del servicio deportivo

El objeto del estudio consiste en realizar un control descriptivo y gráfico sobre las actividades dirigidas que se ofertan y desarrollan en el Centro Deportivo Mediterráneo Cartagena con el fin de controlar, buscar y orientar hacia donde se mueven los intereses de los usuarios en relación a preferencias de bandas horarias y actividades más demandadas, buscando los aspectos e indicadores que nos lleven a una mejora de los niveles en la calidad del servicio. Los resultados, además de ayudarnos a rediseñar la oferta de servicios nos servirá para ofrecer recomendaciones para el diseño de tablas de control de usuario para su posterior uso como herramienta de control y evaluación

Autonomy and isolation experienced by patients and primary caregivers during COVID-19 hospitalization in Barcelona (Spain)

SARS-CoV-2; Autonomy; IsolationSARS-CoV-2; Autonomía; AislamientoSARS-CoV-2; Autonomia; AïllamentThis study aims to describe patients' and family caregivers' hospitalization experiences during the COVID-19 pandemic. Using qualitative exploratory descriptive methods, 13 patients admitted to the largest hospital in Barcelona (Spain) due to COVID-19 were interviewed by telephone once discharged, as were eight primary caregivers. Data were analyzed using the content analysis method proposed by Krippendorff. Two main themes were identified: (i) Acceptance of mandatory isolation for patients and family caregivers, which refers to the verbalization of a feeling that justifies the imposed isolation and the need for the use of personal protective equipment by the health team for everyone's safety; and (ii) Limited autonomy during hospitalization for patients and family caregivers, which describes participants' perceptions of autonomy during hospitalization. Patients and caregivers experienced feelings of loneliness, which negatively affected their emotional health. In addition, they experienced reduced autonomy due to new habits and routines intended to control the pandemic for the benefit of public and global health

Estudio descriptivo longitudinal y de concordancia diagnóstica entre Atención Primaria y Psicología del Programa de Soporte a Atención Primaria. Abstract

Background: The objective was to describe the characteristics of a primary support program (PSP) and to analyze diagnostic concordance between primary care physicians (PCP) and psychologists over three years. Material and method: A descriptive, longitudinal prospective study over three years at five primary care centers in Barcelona. The sample was 1722 patients referred to psychology services. Descriptive statistics used to analyze sociodemographic variables and Cohen's Kappa to assess agreement. Results: The average waiting time between referral and first visit was 37.54 days. Stable over the three years were the number of highs (34%), the number of cases of not presenting to first visit (21.4%), treatment dropout (19.9%), and referrals to other services (19.5%). There was a low overall concordance between PCP and psychologist. PCP most frequently diagnosed anxiety disorder. Psychologists most frequently diagnosed depression and anxiety. The highest concordance (2010:  0.343, 2011: 0.456, 2012: 0.662 Kappa Index) was observed in the diagnosis of eating behavior disorders followed by depression (2010: 0.302, 2011: 0.367, 2012: 0.362) and anxiety (2010: 0.245, 2011: 0.278, 2012: 0.296). Conclusions: PSP offers specialized brief interventions in primary care. Progressive increase of slight concordance was observed between professionals, while remaining close to the baseline percentage, indicating the need for increased opportunities for consultation.Fundamento y objetivo: Describir las características del Programa de Soporte a la Primaria (PSP) y analizar la concordancia diagnóstica entre Médicos/as de Atención Primaria (MAP) y Psicólogos/as del programa a lo largo de tres años. Material y método: Estudio descriptivoprospectivoy longitudinal realizado a tres años en 5 Áreas Básicas de Salud de la provincia de Barcelona. La muestra son 1722 pacientes derivados a psicología. Se utilizan estadísticos descriptivos para analizar las variables sociodemográficas y la kappa de Cohen para valorar la concordancia.Resultados: El tiempo de espera medio entre derivación y primera visita es 37,54 días. La media de intervenciones por paciente es 2,64 visitas. Se mantiene estable en los tres años el número de altas (34%), el número de casos no presentados a primera visita (21,4%), el de abandonos de tratamiento (19,9%), y el de derivaciones a otros servicios(19,5%). Existe una baja concordancia global entre MAP y Psicólogo/a a lo largo de los años.El diagnóstico más frecuentemente realizado por los MAP, y con tendencia creciente, es Trastorno de Ansiedad. Los psicólogos/as diagnostican con mayor frecuencia depresión y ansiedad. Se observa la mayor concordancia (Índice Kappa: 2010: 0.343, 2011:0.456, 2012: 0.662) en el diagnóstico de TCA seguido de Depresión ( 2010: 0.302, 2011: 0.367, 2012:0.362) y de Ansiedad (2010: 0.245, 2011: 0.278, 2012: 0.296). Conclusiones: El PSP ofrece intervenciones breves y especializadas desde Atención Primaria. Progresivamente se observa ligero aumento de la concordancia entre profesionales, aunque sigue siendo en porcentajebajo, lo que indicaría la necesidad de continuar aumentando espacios de interconsulta y formación

An open-source development based on photogrammetry for a real-time IORT treatment planning system

Purpose This study presents a treatment planning system for intraoperative low-energy photon radiotherapy based on photogrammetry from real images of the surgical site taken in the operating room. Material and methods The study population comprised 15 patients with soft-tissue sarcoma. The system obtains the images of the area to be irradiated with a smartphone or tablet, so that the absorbed doses in the tissue can be calculated from the reconstruction without the need for computed tomography. The system was commissioned using 3D printing of the reconstructions of the tumor beds. The absorbed doses at various points were verified using radiochromic films that were suitably calibrated for the corresponding energy and beam quality. Results The average reconstruction time of the 3D model from the video sequence in the 15 patients was 229,6±7,0 s. The entire procedure, including video capture, reconstruction, planning, and dose calculation was 520,6±39,9 s. Absorbed doses were measured on the 3D printed model with radiochromic film, the differences between these measurements and those calculated by the treatment planning system were 1.4% at the applicator surface, 2.6% at 1 cm, 3.9% at 2 cm and 6.2% at 3 cm. Conclusions The study shows a photogrammetry-based low-energy photon IORT planning system, capable of obtaining real-time images inside the operating room, immediately after removal of the tumor and immediately before irradiation. The system was commissioned with radiochromic films measurements in 3D-printed model

Programa de soporte a la primaria: Un análisis descriptivo y de concordancia diagnóstica entre médico/a de atención primaria y psicólogo/a.

Objetivos: Describir las características del Programa de Soporte a la Primaria (PSP) y analizar la concordancia diagnóstica entre Médicos de Atención Primaria (MAP) y Psicólogos/as del programa. Metodología: Estudio descriptivo longitudinal realizado en 2010 en 7 CAPs de Barcelona. La muestra son 769 pacientes derivados a psicología. Se utilizan estadísticos descriptivos para analizar las variables sociodemográficas y la kappa de Cohen para valorar la concordancia.Resultados: El tiempo de espera medio entre derivación y primera visita es 28 días. La media de intervenciones por paciente es 3 visitas. Un 27% son dados de alta, un 20% abandonan. Existe una baja concordancia global entre MAP y Psicólogo/a.El diagnóstico más frecuentemente realizado por los MAP es Trastorno de Ansiedad. Los psicólogos/as diagnostican con igual frecuencia Trastornos Ansiosos (21%), Depresión (20.2%) y Trastornos Adaptativos (19.6%).Conclusiones: El PSP ofrece intervenciones breves y especializadas desde Atención Primaria.La baja concordancia indica la necesidad de aumentar espacios de interconsulta

Development of a Novel Anti-CD19 Chimeric Antigen Receptor : A Paradigm for an Affordable CAR T Cell Production at Academic Institutions

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed by CD8 hinge and transmembrane region, 4-1BB- and CD3z-signaling domains. We show that A3B1 CAR T cells are highly cytotoxic and specific against CD19+ cells in vitro, inducing secretion of pro-inflammatory cytokines and CAR T cell proliferation. In vivo, A3B1 CAR T cells are able to fully control disease progression in an NOD.Cg-Prkdc Il2rd/SzJ (NSG) xenograph B-ALL mouse model. Based on the pre-clinical data, we conclude that our CART19 is clearly functional against CD19+ cells, to a level similar to other CAR19s currently being used in the clinic. Concurrently, we describe the implementation of our CAR T cell production system, using lentiviral vector and CliniMACS Prodigy, within a medium-sized academic institution. The results of the validation phase show our system is robust and reproducible, while maintaining a low cost that is affordable for academic institutions. Our model can serve as a paradigm for similar institutions, and it may help to make CAR T cell treatment available to all patients

Development of a novel anti-CD19 chimeric antigen receptor: A paradigm for an affordable CAR T cell production at academic institutions

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed by CD8 hinge and transmembrane region, 4-1BB- and CD3z-signaling domains. We show that A3B1 CAR T cells are highly cytotoxic and specific against CD19+ cells in vitro, inducing secretion of pro-inflammatory cytokines and CAR T cell proliferation. In vivo, A3B1 CAR T cells are able to fully control disease progression in an NOD.Cg-Prkdcscid Il2rdtm1Wjl/SzJ (NSG) xenograph B-ALL mouse model. Based on the pre-clinical data, we conclude that our CART19 is clearly functional against CD19+ cells, to a level similar to other CAR19s currently being used in the clinic. Concurrently, we describe the implementation of our CAR T cell production system, using lentiviral vector and CliniMACS Prodigy, within a medium-sized academic institution. The results of the validation phase show our system is robust and reproducible, while maintaining a low cost that is affordable for academic institutions. Our model can serve as a paradigm for similar institutions, and it may help to make CAR T cell treatment available to all patients

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

Manual del modelo de gestión de la cultura y capacidad de innovación empresarial – CCIE: Una oportunidad para innovar y mejorar el valor diferenciador en las microempresas.

Encontraras el libro completo.La relación empresa-universidad ha cobrado vital importancia en los últimos años. Cada vez más, economías robustas principalmente europeas, se han beneficiado de la aplicación óptima de este tipo de colaboración. Desde el contexto universitario, se busca analizar tendencias y hacer más ágiles las respuestas académicas a las necesidades del entorno. Desde el contexto empresarial, existe la presión de la mejora continua de sus conocimientos y tecnologías, que aseguren su existencia en el largo plazo. Es así como las universidades se convierten en una fuente de investigación alternativa para lo que antes se desarrollaba internamente en las organizaciones y que hoy, por diversos motivos, entre esos el avance tecnológico a pasos agigantados, hace que estas miren a la academia, ya no solo como un formador de profesionales sino como un socio estratégico