La acreditación de profesores por la ANECA: la evaluación de investigación, la docencia y la gestión. El precedente de la evaluación de la investigación en la CNEAI. El caso particular de las Escuelas de Arquitectura.

Los profesores universitarios han de llevar a cabo actividades docentes, investigadoras y de gestión. Sin embargo, tradicionalmente ha prevalecido en las Escuelas de Arquitectura la idea de que la formación de profesionales constituía la única misión de los centros, quedando relegada la investigación a unos pocos, muy pocos en un principio. Desde que el Plan de Estudios de 1957 estableciera el título de Doctor en Arquitectura mediante la realización de tesis doctorales, la componente investigadora fue adquiriendo entidad, primero de manera precaria y minoritaria, intensificándose posteriormente, poco a poco, hasta alcanzar una cierta entidad, tratando de converger con los campos de mayor tradición y desarrollo investigador. Por mas que aún no puedan homologarse, ni quizá deba hacerse por el mismo rasero de los centros científicos y tecnológicos puros.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Plasma metabolomic profile is near-normal in people with HIV on long-term suppressive antiretroviral therapy

BackgroundCombination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression and satisfactory immunological recovery. We aimed to determine whether the plasma metabolomic profile of PWH on long-term suppressive ART and immunologically recovered approximates the normality by comparison with healthy controls with similar age and gender.MethodsWe carried out a cross-sectional study in 17 PWH on long-term ART (HIV-RNA <50 copies/mL, CD4+ ≥500 cells/mm3, and CD4+/CD8+ ≥1) and 19 healthy controls with similar age and gender. Metabolomics analysis was performed by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The statistical association analysis was performed by principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and Generalized Linear Models (GLM) with a gamma distribution (log-link). Significance levels (p-value) were corrected for multiple testing (q-value).ResultsPCA and PLS-DA analyses found no relevant differences between groups. Adjusted GLM showed 14 significant features (q-value<0.20), of which only three could be identified: lysophosphatidylcholine (LysoPC) (22:6) (q-value=0.148), lysophosphatidylethanolamine (LysoPE) (22:6) (q-value=0.050) and hydroperoxy-octadecatrienoic acid (HpOTrE)/dihydroperoxy-octadecatrienoic acid (DiHOTrE)/epoxy-octadecadienoic acid (EpODE) (q-value=0.136). These significant identified metabolites were directly correlated to plasma inflammatory biomarkers in PWH and negatively correlated in healthy controls.ConclusionPWH on long-term ART have a metabolomic profile that is almost normal compared to healthy controls. Nevertheless, residual metabolic alterations linked to inflammatory biomarkers persist, which could favor the development of age-related comorbidities among this population

DataSheet_1_Plasma metabolomic profile is near-normal in people with HIV on long-term suppressive antiretroviral therapy.docx

BackgroundCombination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression and satisfactory immunological recovery. We aimed to determine whether the plasma metabolomic profile of PWH on long-term suppressive ART and immunologically recovered approximates the normality by comparison with healthy controls with similar age and gender.MethodsWe carried out a cross-sectional study in 17 PWH on long-term ART (HIV-RNA + ≥500 cells/mm3, and CD4+/CD8+ ≥1) and 19 healthy controls with similar age and gender. Metabolomics analysis was performed by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The statistical association analysis was performed by principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and Generalized Linear Models (GLM) with a gamma distribution (log-link). Significance levels (p-value) were corrected for multiple testing (q-value).ResultsPCA and PLS-DA analyses found no relevant differences between groups. Adjusted GLM showed 14 significant features (q-valueConclusionPWH on long-term ART have a metabolomic profile that is almost normal compared to healthy controls. Nevertheless, residual metabolic alterations linked to inflammatory biomarkers persist, which could favor the development of age-related comorbidities among this population.</p