11 research outputs found
Practical implications of using real-world evidence (RWE) in comparative effectiveness research: Learnings from IMI-GetReal
In light of increasing attention towards the use of real-world evidence (RWE) in decision making in recent years, this commentary aims to reflect on the experiences gained in accessing and using RWE for comparative effectiveness research as a part of the Innovative Medicines Initiative GetReal Consortium and discuss their implications for RWE use in decision-making
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
Publisher's version (útgefin grein).Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5–BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10−21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.We are grateful to the participants and we thank the staff at the Research
Recruitment Center. We also thank the staff at deCODE genetics core facilities
and all our colleagues for their important contribution to this work. We are
grateful to the Benefit Society for Children with Disabilities (Styrktarfélag
Lamaðra og Fatlaðra; SLF) for their participation. The research leading to these
results has received support from the Innovative Medicines Initiative Joint
Undertaking under grant agreements’ no. 115008 (NEWMEDS) and no. 115300
(EUAIMS), of which resources are composed of EFPIA in-kind contribution and
financial contribution from the European Union’s Seventh Framework
Programme (EU-FP7/2007–2013), from EU-FP7 grants no. 602450
(IMAGEMEND) and no. 502805 (Aggressotype), EU-FP7-People-2011-IAPP grant
no. 286213 (PsychDPC), and The Research Council of Norway (#226971,
229129, 223273, 213694, 248778), the KG Jebsen Stiftelsen (SKGJ-MED-002 and
SKGJ-MED-008), and The South-East Norway Health Authority (#2012–132).Peer Reviewe
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
Publisher Copyright: © 2023, The Author(s).Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of 45,510 Icelandic and 130,709 UK Biobank participants combined with a mutational barcode method, we identified 16,306 people with CH. Prevalence approaches 50% in elderly participants. Smoking demonstrates a dosage-dependent impact on risk of CH. CH associates with several smoking-related diseases. Contrary to published claims, we find no evidence that CH is associated with cardiovascular disease. We provide evidence that CH is driven by genes that are commonly mutated in myeloid neoplasia and implicate several new driver genes. The presence and nature of a driver mutation alters the risk profile for hematological disorders. Nevertheless, most CH cases have no known driver mutations. A CH genome-wide association study identified 25 loci, including 19 not implicated previously in CH. Splicing, protein and expression quantitative trait loci were identified for CD164 and TCL1A.Peer reviewe
Using Real-World Data in Health Technology Assessment (HTA) Practice:A Comparative Study of Five HTA Agencies
BACKGROUND: Reimbursement decisions are conventionally based on evidence from randomised controlled trials (RCTs), which often have high internal validity but low external validity. Real-world data (RWD) may provide complimentary evidence for relative effectiveness assessments (REAs) and cost-effectiveness assessments (CEAs). This study examines whether RWD is incorporated in health technology assessment (HTA) of melanoma drugs by European HTA agencies, as well as differences in RWD use between agencies and across time. METHODS: HTA reports published between 1 January 2011 and 31 December 2016 were retrieved from websites of agencies representing five jurisdictions: England [National Institute for Health and Care Excellence (NICE)], Scotland [Scottish Medicines Consortium (SMC)], France [Haute Autorité de santé (HAS)], Germany [Institute for Quality and Efficacy in Healthcare (IQWiG)] and The Netherlands [Zorginstituut Nederland (ZIN)]. A standardized data extraction form was used to extract information on RWD inclusion for both REAs and CEAs. RESULTS: Overall, 52 reports were retrieved, all of which contained REAs; CEAs were present in 25 of the reports. RWD was included in 28 of the 52 REAs (54%), mainly to estimate melanoma prevalence, and in 22 of the 25 (88%) CEAs, mainly to extrapolate long-term effectiveness and/or identify drug-related costs. Differences emerged between agencies regarding RWD use in REAs; the ZIN and IQWiG cited RWD for evidence on prevalence, whereas the NICE, SMC and HAS additionally cited RWD use for drug effectiveness. No visible trend for RWD use in REAs and CEAs over time was observed. CONCLUSION: In general, RWD inclusion was higher in CEAs than REAs, and was mostly used to estimate melanoma prevalence in REAs or to predict long-term effectiveness in CEAs. Differences emerged between agencies' use of RWD; however, no visible trends for RWD use over time were observed
Using Real-World Data in Health Technology Assessment (HTA) Practice : A Comparative Study of Five HTA Agencies
BACKGROUND: Reimbursement decisions are conventionally based on evidence from randomised controlled trials (RCTs), which often have high internal validity but low external validity. Real-world data (RWD) may provide complimentary evidence for relative effectiveness assessments (REAs) and cost-effectiveness assessments (CEAs). This study examines whether RWD is incorporated in health technology assessment (HTA) of melanoma drugs by European HTA agencies, as well as differences in RWD use between agencies and across time. METHODS: HTA reports published between 1 January 2011 and 31 December 2016 were retrieved from websites of agencies representing five jurisdictions: England [National Institute for Health and Care Excellence (NICE)], Scotland [Scottish Medicines Consortium (SMC)], France [Haute Autorité de santé (HAS)], Germany [Institute for Quality and Efficacy in Healthcare (IQWiG)] and The Netherlands [Zorginstituut Nederland (ZIN)]. A standardized data extraction form was used to extract information on RWD inclusion for both REAs and CEAs. RESULTS: Overall, 52 reports were retrieved, all of which contained REAs; CEAs were present in 25 of the reports. RWD was included in 28 of the 52 REAs (54%), mainly to estimate melanoma prevalence, and in 22 of the 25 (88%) CEAs, mainly to extrapolate long-term effectiveness and/or identify drug-related costs. Differences emerged between agencies regarding RWD use in REAs; the ZIN and IQWiG cited RWD for evidence on prevalence, whereas the NICE, SMC and HAS additionally cited RWD use for drug effectiveness. No visible trend for RWD use in REAs and CEAs over time was observed. CONCLUSION: In general, RWD inclusion was higher in CEAs than REAs, and was mostly used to estimate melanoma prevalence in REAs or to predict long-term effectiveness in CEAs. Differences emerged between agencies' use of RWD; however, no visible trends for RWD use over time were observed
Weak Business Culture as an Antecedent of Economic Crisis: The Case of Iceland
business culture, business ethics, corruption, Iceland,
Working Group on Nephrops Surveys (WGNEPS; outputs from 2022 meeting)
The Working Group on Nephrops Surveys (WGNEPS) is the international coordination group for Nephrops underwater television and trawl surveys within ICES. This report summarizes the national contributions on the results of the surveys conducted in 2022 together with time series covering all survey years, problems encountered, data quality checks and technological improvements as well as the planning for survey activities for 2023.In total, 21 surveys covering 26 functional units (FU’s) in the ICES area and 1 geographical subarea (GSA) in the Adriatic Sea were discussed and further improvements in respect to survey design and data analysis standardization and the use of most recent technology were reviewed. The first exploratory UWTV survey on the FU 25 Nephrops grounds was also presented to the group.The results of the evaluation of reference sets for FU3&4 Skagerrak/Kattegat were accepted following the process set down by the 2018 workshop (WKNEPS).An alternative method estimate Nephrops abundance was shown to the group using the recently published R package sdmTMB.The group agreed to hold a workshop in 2025 to address burrow size estimations to update correction factors and terms of reference for this to be agreed at next meeting.Automatic burrow detection based on deep learning methods continues to show promising results where datasets from multiple institutes were used.Plans are being progressed for an international Nephrops UWTV database to be established at the ICES data centre with a sub-grou