78 research outputs found
Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a Novel Anti-Inflammatory Drug Candidate
BACKGROUND: 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered heterocyclic compound containing a N-O bond. The anti-inflammatory effects of this compound were studied both in vitro and in vivo. PRINCIPAL FINDINGS: DIC effectively decreased TNF-α and IL-6 release from LPS-stimulated macrophages in a dose dependent manner. DIC diminished the levels of COX-2 with subsequent inhibition of PGE(2) production. DIC also compromised HMGB1 translocation from the nucleus to the cytoplasm. Moreover, DIC prevented the nuclear translocation of NF-κB and inhibited the MAPK pathway. In vivo, DIC inhibited migration of neutrophils to the peritoneal cavity of mice. CONCLUSIONS: This study presents the potential utilization of a synthetic compound, as a lead for the development of novel anti-inflammatory drugs
Instabilities in extreme magnetoconvection
Thermal convection in an electrically conducting fluid (for example, a liquid
metal) in the presence of a static magnetic field is considered in this
chapter. The focus is on the extreme states of the flow, in which both buoyancy
and Lorentz forces are very strong. It is argued that the instabilities
occurring in such flows are often of unique and counter-intuitive nature due to
the action of the magnetic field, which suppresses conventional turbulence and
gives preference to two-dimensional instability modes not appearing in more
conventional convection systems. Tools of numerical analysis suitable for such
flows are discussed
Analysis of Natural Convection in a Low Gravity Environment
Natural convection inside a spherical container was studied experimentally with two apparatuses at low buoyancy levels. The data generated by these experiments, plotted nondimensionally as the Nusselt versus Rayleigh numbers, gives correlations for Rayleigh numbers between 103 and 108, a range which was previously untested. These results show that natural convection has significant effects at a Rayleigh number of 10\u3esup\u3e3 and higher, although the behavior of the Nusselt number as the conduction limit is approached is still unknown for a spherical geometry
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