Inverse problems for Sturm-Liouville equations with boundary conditions linearly dependent on the spectral parameter from partial information

[[abstract]]Abstract.In this paper, we study the inverse spectral problems for Sturm–Liouville equations with boundary conditions linearly dependent on the spectral parameter and show that the potential of such problem can be uniquely determined from partial information on the potential and parts of two spectra, or alternatively, from partial information on the potential and a subset of pairs of eigenvalues and the normalization constants of the corresponding eigenvalues.[[notice]]補正完畢[[journaltype]]國外[[incitationindex]]SCI[[ispeerreviewed]]Y[[booktype]]紙本[[booktype]]電子版[[countrycodes]]DE

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Управління бізнес-інноваціями: систематизація наукового доробку у сфері формування лідерських компетенцій

Фактори лідерства та компетенцій, що його формують постійно досліджуються науковою спільнотою, що тим самим підтверджує актуальність вивчення даної тематики. Авторами наголошено, що у широкому сенсі лідерство формує поведінку співробітників і сприяє процесам досягнення загальних цілей і завдань організації. У сучасному інноваційному та швидко мінливому світі практичне та якісне лідерство є важливою темою для вивчення. Ефективне та зразкове лідерство, також відоме як позитивне лідерство, мотивує неефективних співробітників, розвиває їхні компетенції, нівелює негативне ставлення, підвищує ефективність управління стресом та елімінує вигорання. Позитивна психологія – це нова сфера знань про організаційну поведінку. Позитивне лідерство в значній мірі залежить від характеру особистості та загальноприйнятих чеснот. Чесноти, які є джерелом добробуту, формують мислення та поведінку особистості, які проявляються як принципи ділової етики у бізнес-середовищі. Чесноти відіграють впливову та життєво важливу роль у різних стилях лідерства, таких як етичне, духовне та трансформаційне лідерство. З іншого боку, ці стилі лідерства не в повному обсязі визначають основні характеристики доброчесного лідера. У цьому напрямку за останнє десятиліття розроблено численні теорії та моделі доброчесного лідерства, які визначають незмінність та доцільність врахування чеснот. Огляд попередніх досліджень виявив прогалину в літературі про доброчесне лідерство. Проблема цього дослідження полягає в тому, що доброчесне лідерство розглядалося в основному з точки зору етики. Це дослідження має на меті сформувати теоретико-методологічний базис доброчесного лідерства на основі результатів узагальнення наукового доробку у цій сфері. У статті використано такі методи дослідження як наукової абстракції та узагальнення. Авторами систематизовано підходи до трактування поняття доброчесне лідерство. Узагальнено теорії і моделі доброчесного лідерства, підходи до класифікації, а також представлено теорії лідерства, що відображають специфіку врахування чеснот.The concept of leadership continues to develop as a concept that still maintains its importance. In the most general sense, leadership shapes employees’ behaviours and facilitates all processes to achieve common goals and objectives. In today's innovative and rapidly changing business world, practical and good leadership is an important study topic in management studies. Effective and good leadership, also known as positive leadership, motivates ineffective employees, develops their skills, improves negative attitudes and behaviours and copes with stress and burnout. Positive Psychology is the newly advancing field of organisational behaviour sciences. Positive leadership highly addresses its relevance with positive character traits as defined virtue. Virtues, which are the source of well-being and glorify people's feelings, thoughts and behaviours, manifest as business ethics principles in business life. The virtues play an influential and vital role in various leadership styles, such as ethical, spiritual and transformational leadership. On the other hand, these leadership styles do not extensively define the core characteristics of a virtuous leader. In this direction, over the past decade, numerous virtuous leadership theories and models have recently developed that cite virtues as essential and indispensable. A review of previous studies revealed a gap in the literature on virtuous leadership. The problem of this study is that virtuous leadership has been examined in primarily ethical literature. This study aims to conceptualise by examining the prominent approaches of virtuous leadership according to the current literature. Traditional literature scrutiny is used as the research method in the paper. Studies are scattered in the relevant literature. This paper summarises the existing virtuous leadership literature and brings out a literature review. The study provides an overview of virtuous leadership theories and models among the definitions and classifications listed in Table 1 and also presents virtues-relevant leadership theories in the literature. Thence, it is expected to contribute to management, leadership and organisational behaviour. The research is a current study in terms of the subject discussed

Voltammetric and RP-LC assay for determination of benidipine HCl

PubMed ID: 22483669The detailed electrooxidative behavior of benidipine (BEN) has been studied by using glassy carbon (GC) and boron-doped diamond (BDD) electrodes. Using cyclic voltammetry, depending on the pH values and the working electrodes, BEN showed one or two sharp and irreversible oxidation responses. The voltammetric experiments on some model compounds allowed elucidation of the oxidation mechanism of BEN. Highly sensitive, selective, rapid, and fully validated voltammetric methods for the determination of BEN in tablet dosage form were also presented. Under optimized conditions, the peak current showed a linear dependence with concentration in the range between 3.25?gmL -1 and 54.20?gmL -1 for GC and 1.08?gmL -1 and 54.20?gmL -1 for BDD electrodes by using differential pulse (DPV) and square wave (SWV) voltammetric techniques. In this study, acid dissociation constant (pK a) value of BEN was determined by using the dependence of the retention factor on the pH of the mobile phase using reverse phase-liquid chromatographic (RP-LC) method. The effect of the composition of the mobile phase on the ionization constant was studied by measuring the pK a at different acetonitrile-water mixtures, ranging between 50 and 65% (v/v). Also simple, accurate, precise and fully validated RP-LC method for the assay of BEN in dosage form has been developed. XTerra RP-18 column at 25°C with the mobile phase of acetonitrile:water 55:45 (v/v) adjusted to pH 3.0 with 15mM o-phosphoric acid was used. Isocratic elution was performed in less than 5.0min with a flow rate of 1.0mLmin -1. The RP-LC method allowed quantitation over the 0.25-15.00?gmL -1 range for BEN. The proposed voltammetric and RP-LC methods allow a number of cost and time saving benefits. BEN was also exposed to thermal, photolytic, oxidative stress, acid-base catalyzed hydrolyses, and the stressed samples were detected by the proposed RP-LC method. © 2012 Elsevier B.V

Development and Validation of a Green Capillary Electrophoretic Method for Determination of Polyphenolic Compounds in Red Wine Samples

A sensitive, simple, rapid, experimentally convenient, cost-effective, environmentally friendly and high-throughput green chemistry by capillary electrophoresis (CE) approach for the determination of eight polyphenolics frequently found in red wines from USA was carried without using toxic organic modifier. Several parameters which affect the separation were investigated to determine the optimum conditions. At room temperature, the eight polyphenolics could be well separated within 15 min in a 55-cm length capillary at a separation voltage of 26 kV with 40-mM borate buffer (pH 8.9). The method was fully validated showing satisfactory data for all method validation parameters tested. The limits of detection varied from 0.15 to 0.32 µM. The relative standard deviations of migration varied from 0.208 to 0.630 %. The Californian red wine samples analyzed were bought in the local markets, and the polyphenolic compound recoveries were in the range of 98–99.7 %. The method was successfully applied to the determination of the studied polyphenolics in red wine samples with satisfactory recoveries. Catechin, syringic acid, apigenin, myricetin, luteolin, quercetin, caffeic acid, and gallic acid were detected in all samples, with gallic acid and myricetin occurring in the highest concentration. © 2016, Springer-Verlag Berlin Heidelberg

A novel RP-LC method for determination of pK a values of some anticancer agents and their assay

A simple, reliable, and rapid RP-LC method has been developed for the determination of some anticancer drugs (daunorubicin, doxorubicin and vincristine sulfate) in their dosage forms and human urine. These compounds are well separated on a C18 column using the mobile phase consisting of a mixture of acetonitrile (50:50; v/v) at a flow rate of 1.5 mL min-1. The analyte peaks were detected at 235 nm for doxorubicin and daunorubicin, and 220 nm for vincristine. Linearity was obtained in different concentration ranges between 0.10 and 12 ?g mL-1 for all compounds. Good sensitivity for all analytes was observed with DAD detection. LOD and LOQ of the method were found satisfying. The proposed method has been extensively validated in accordance with ICH guidelines and obtained results proved that the proposed method was precise, accurate, selective, and sensitive for simultaneous analysis of studied compounds. All analytical procedures including sample preparation, flow rate, and run time were at low levels. Also, pK a values were determined using the dependence of the retention factor on the pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pK a at different methanol-water mixtures, ranging between 45 and 60 % (v/v). © 2013 Springer-Verlag Berlin Heidelberg.111T627Acknowledgments The authors are thankful for the financial aid received from the Scientific and Technological Research Council of Turkiye (TUBITAK), Project No. 111T627. We gratefully acknowledge to Dr. Jose Luis Beltran from the University of Barcelona for kindly providing the NLREG 4.0 and STAR programs

Development and validation of a liquid chromatographic method for concurrent assay of weakly basic drug verapamil and amphoteric drug trandolapril in pharmaceutical formulations

The analysis of weakly basic drugs such as verapamil by reverse-phase liquid chromatography remains a problem, particularly when present in combination with other drugs such as amphoteric compounds like trandolapril. In this study, the simple, accurate, precise and fully validated RP-LC method for the simultaneous determination of verapamil and trandolapril in combined dosage forms has been developed. The LC method allowed quantitation over the ranges of 0.50-18.00 ?g/mL and 0.05-1.00 ?g/mL for verapamil and trandolapril, respectively. The detection limits were found to be 0.008 ?g/mL and 0.018 ?g/mL for verapamil and trandolapril, respectively. Moreover, pKa values of verapamil and trandolapril were determined via the dependence of the retention factor on the pH of the mobile phase for ionizable substances. The effect of the mobile phase composition on the ionization constant was studied by measuring the pKa at different methanol-water mixtures, ranging 50-65% (v/v). It was shown that RP-HPLC was suitable for the high throughput analysis of the combination of verapamil and trandolapril. The method also allows a number of cost and time saving benefits and can be readily employed for the analysis of pharmaceutical formulations. The method has been verified, without any interference from excipients, for the concurrent analysis of these compounds in tablets