5 research outputs found
The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox
Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease
The Association between Serum Heme Oxygenase-1 Levels and Coronary SYNTAX Score
Aim: The relationship between heme oxygenase-1 (HO-1) levels and atherosclerosis was investigated in multiple studies. The aim of this study was to establish the relationship between HO-1 levels and coronary SYNergy between percutaneous coronary intervention with TAXus and Cardiac Surgery (SYNTAX) score in patients with stable coronary artery disease (CAD). Methods: Patients who had been planned to undergo invasive coronary angiography due to a suspected CAD, between the dates of September and December 2019, were included in the study. Serum HO-1 levels were measured from peripheral venous blood. The SYNTAX score was calculated using standard coronary angiography images. Regression analysis was performed to establish the relationship between HO-1 levels and the SYNTAX score. Results: In total, 137 patients were included. The median age was 63 years (IQR: 15), and most of the patients were male (75.2%). The median HO-1 level was 1.44 (IQR: 0.88) ng/mL, and the median SYNTAX score was 6 (IQR: 13). Regression analysis showed that HO-1 is the single most important variable associated with the SYNTAX score (HO-1 levels from 1.01 to 1.87 ng/mL, OR: 6.77, 95% confidence interval 5.18-8.36, p < 0.0001). Conclusion: In this study, serum HO-1 levels were significantly associated with the coronary SYNTAX score
The Association of Left Ventricular End-Diastolic Pressure and Acute Left Ventricular End-Diastolic Pressure Change with Miyocardial Blush Grade and ST Segment Resolution in STEMI Patients Undergoing Primary Percutaneous Intervention
The effect of idiopathic premature ventricular complexes on left ventricular ejection fraction
Aim Current literature lacks a definitive threshold of idiopathic
premature ventricular complex (PVC) burden for predicting cardiomyopathy
(CMP). The main objective of the present study was to evaluate
relationship between the PVC burden and left ventricular ejection
fraction (LVEF).
Method This multicenter, cross-sectional study included 341 consecutive
patients with more than 1,000 idiopathic PVC in 24 hr of Holter
monitoring admitted to the cardiology clinics between January 2019 and
May 2019 in the nineteen different centers. The primary outcome was the
LVEF measured during the echocardiographic examination.
Result Overall, the median age was 50 (38-60) and 139 (49.4\%) were
female. Percentage of median PVC burden was 9\% (IQR: 4\%-17.4\%).
Median LVEF was found 60\% (55-65). We used proportional odds logistic
regression method to examine the relationship between continuous LVEF
and candidate predictors. Increase in PVC burden (\%) (regression
coefficient (RE) -0.644 and 95\% CI -1.063, -0.225, p < .001), PVC QRS
duration (RE-0.191 and 95\% CI -0.529, 0.148, p = .049), and age
(RE-0.249 and 95\% CI -0.442, -0.056, p = .018) were associated with
decrease in LVEF. This inverse relationship between the PVC burden and
LVEF become more prominent when PVC burden was above 5\%. A nomogram
developed to estimate the individual risk for decrease in LVEF.
Conclusion Our study showed that increase in PVC burden \%, age, and PVC
QRS duration were independently associated with decrease in LVEF in
patients with idiopathic PVC. Also, inverse relationship between PVC
burden and LVEF was observed in lower PVC burden than previously known