A Measurement of Proper Motions of SiO Maser Sources in the Galactic Center with the VLBA

We report on the high-precision astrometric observations of maser sources around the Galactic Center in the SiO J=1--0 v=1 and 2 lines with the VLBA during 2001 -- 2004. With phase-referencing interferometry referred to the radio continuum source Sgr A*, accurate positions of masers were obtained for three detected objects: IRS 10 EE (7 epochs), IRS 15NE (2 epochs), and SiO 6 (only 1 epoch). Because circumstellar masers of these objects were resolved into several components, proper motions for the maser sources were derived with several different methods. Combining our VLBA results with those of the previous VLA observations, we obtained the IRS 10EE proper motion of 76+-3 km s^{-1} (at 8 kpc) to the south relative to Sgr A*. Almost null proper motion of this star in the east--west direction results in a net transverse motion of the infrared reference frame of about 30+-9 km s^{-1} to the west relative to Sgr A*. The proper-motion data also suggests that IRS 10EE is an astrometric binary with an unseen massive companion.Comment: High-res. figures are available at ftp://ftp.nro.nao.ac.jp/nroreport/no656.pdf.gz . PASJ 60, No. 1 (2008) in pres

Slow relaxation to equipartition in spring-chain systems

In this study, one-dimensional systems of masses connected by springs, i.e., spring-chain systems, are investigated numerically. The average kinetic energy of chain-end particles of these systems is larger than that of other particles, which is similar to the behavior observed for systems made of masses connected by rigid links. The energetic motion of the end particles is, however, transient, and the system relaxes to thermal equilibrium after a while, where the average kinetic energy of each particle is the same, that is, equipartition of energy is achieved. This is in contrast to the case of systems made of masses connected by rigid links, where the energetic motion of the end particles is observed in equilibrium. The timescale of relaxation estimated by simulation increases rapidly with increasing spring constant. The timescale is also estimated using the Boltzmann-Jeans theory and is found to be in quite good agreement with that obtained by the simulation

p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels.

BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts to suppress cell cycle progression and to prevent apoptosis. Because defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in PKD, and in light of earlier reports that polycystin-1 upregulates p21 and that the cyclin-dependent kinase inhibitor roscovitine arrests progression in a mouse model, we asked whether (1) p21 deficiency might underlie ADPKD and (2) the mechanism of the salutary roscovitine effect on PKD involves p21.Methodsp21 levels in human and animal tissue samples as well as cell lines were examined by immunoblotting and/or immunohistochemisty. Apoptosis was assessed by PARP cleavage. p21 expression was attenuated in a renal tubular epithelial cell line by antisense methods, and proliferation in response to p21 attenuation and to roscovitine was assessed by the MTT assay.ResultsWe show that p21 is decreased in human as well as a non-transgenic rat model of ADPKD. In addition, hepatocyte growth factor, which induces transition from a cystic to a tubular phenotype, increases p21 levels. Furthermore, attenuation of p21 results in augmentation of cell cycle transit in vitro. Thus, levels of p21 are inversely correlated with renal tubular epithelial cell proliferation. Roscovitine, which has been shown to arrest progression in a murine model of PKD, increases p21 levels and decreases renal tubular epithelial cell proliferation, with no affect on apoptosis.ConclusionThe novelty of our study is the demonstration in vivo in humans and rat models of a decrement of p21 in cystic kidneys as compared to non-cystic kidneys. Validation of a potential pathogenetic model of increased cyst formation due to enhanced epithelial proliferation and apoptosis mediated by p21 suggests a mechanism for the salutary effect of roscovitine in ADPKD and supports further investigation of p21 as a target for future therapy

Subdiffusive axial transport of granular materials in a long drum mixer

Granular mixtures rapidly segregate radially by size when tumbled in a partially filled horizontal drum. The smaller component moves toward the axis of rotation and forms a buried core, which then splits into axial bands. Models have generally assumed that the axial segregation is opposed by diffusion. Using narrow pulses of the smaller component as initial conditions, we have characterized axial transport in the core. We find that the axial advance of the segregated core is well described by a self-similar concentration profile whose width scales as $t^\alpha$, with $\alpha \sim 0.3 < 1/2$. Thus, the process is subdiffusive rather than diffusive as previously assumed. We find that $\alpha$ is nearly independent of the grain type and drum rotation rate within the smoothly streaming regime. We compare our results to two one-dimensional PDE models which contain self-similarity and subdiffusion; a linear fractional diffusion model and the nonlinear porous medium equation.Comment: 4 pages, 4 figures, 1 table. Submitted to Phys Rev Lett. For more info, see http://www.physics.utoronto.ca/nonlinear

LHR band emissions at mid-latitude and their relationship to ionospheric ELF hiss and relativistic electrons

LHR band emissions observed at mid-latitude were investigated using data from the EXOS-C (Ohzora) satellite. A typical feature of the LHR band emissions is a continuous banded structure without burst-like and cut-off features whose center frequency decreases as the satellite moves to higher latitudes. A statistical analysis of the occurrence characteristics of the phenomena showed that mid-latitude LHR emissions are distributed inside the plasmapause during magnetically quiet periods, and the poleward boundary of the emission region moves to lower latitudes as the magnetic activity increases. The altitude distribution of the waves suggests that the propagation in the LHR duct formed horizontally in the mid-latitude upper-ionosphere. The emission is closely related to the occurrence of ionospheric ELF hiss. It is also shown that LHR emissions are commonly observed in the slot region of the radiation belt, and they sometimes accompany the enhancement of the ionospheric electron temperature. The generation of the LHR band emissions is discussed based on the observed characteristics

Efficacy of conversion gastrectomy following docetaxel, cisplatin, and S-1 therapy in potentially resectable stage IV gastric cancer

AbstractBackgroundRecent advances in gastric cancer chemotherapy have made macroscopic complete resection possible in some patients with stage IV disease.MethodsWe retrospectively investigated the efficacy of multimodal therapy with combined docetaxel, cisplatin, and S-1 (DCS) and conversion gastrectomy in 57 patients with stage IV gastric cancer.ResultsOf the 57 patients, 15 patients were categorized into potentially resectable case, which is defined as patients with single incurable factor including the upper abdominal para-aortic lymph node metastasis (16a2b1 PAN metastasis) or fewer than three peripheral liver metastases. The other 42 were categorized as initially unresectable. All of patients underwent DCS therapy, and then 34 patients underwent conversion gastrectomy. The 3-year overall survival (OS) rate among the patients who underwent conversion gastrectomy was 50.1% with MST of 29.9 months. They had significantly longer OS than patients who underwent DCS therapy alone (p < 0.01). Univariate analysis among the patents with conversion gastrectomy identified 16a2b1PAN metastasis, peritoneal metastasis, potential resectable case, R0 resection as significant prognostic factors. A 3-year OS in potential resectable cases was 92.9%. Multivariate analysis identified potential resectability as the only independent prognostic factor contributing to OS (HR 0.133, 95%CI 0.024-0. 744, p = 0.021). In contrast, clinical response was selected as the only independent prognostic factor in the subgroup of initially unresectable cases (HR 0.354, 95%CI 0.151-0.783, p = 0.021).ConclusionPatients with potentially resectable disease had a remarkably good prognosis among stage IV gastric cancer patients, and might be ideal candidates for conversion gastrectomy following DCS therapy