Neutron skin of 208^{208}Pb from Coherent Pion Photoproduction

Information on the size and shape of the neutron skin on $^{208}$Pb has been extracted from coherent pion photoproduction cross sections measured using the Crystal Ball together with the Glasgow tagger at the MAMI electron beam facility. On exploitation of an interpolated fit of a theoretical model to the measured cross sections the half-height radius and diffuseness of the neutron distribution are found to be 6.70$\pm 0.03(stat)$ fm and 0.55$\pm 0.01(stat)$$^{+0.02}_{-0.03}(sys)$ fm respectively, corresponding to a neutron skin thickness $\Delta r_{np}$=0.15$\pm 0.03(stat)$$^{+0.01}_{-0.03}(sys)$ fm. The results give the first successful extraction of a neutron skin with an electromagnetic probe and indicate the skin of $^{208}$Pb has a halo character. The measurement provides valuable new constraints on both the structure of nuclei and the equation of state for neutron-rich matter.Comment: 4 figures 5 pages. Version submitted to journal. Includes additional studies of systematic effects in the extracted diffuseness, which led to a small increase in the quoted systematic error. These additional studies are discussed in the revised manuscript. Also includes minor editorial improvements to the tex

Determination of the Dalitz plot parameter alpha for the decay eta->3pi^0 with the Crystal Ball at MAMI-B

A precise measurement of the Dalitz plot parameter, alpha, for the eta->3pi^0 decay is presented. The experiment was performed with the Crystal Ball and TAPS large acceptance photon detectors at the tagged photon beam facility of the MAMI-B electron accelerator in Mainz. High statistics of 1.8*10^6 eta->3pi^0 events were obtained, giving the result alpha = -0.032 +/- 0.002(stat) +/- 0.002(syst).Comment: 9 pages, 6 figures, published in the online-first section of EPJ A, included changes referees asked for, added DO

Measurements of 12C(→γ,pp) photon asymmetries for Eγ= 200–450 MeV

The 12C (→γ ,pp) reaction has been studied in the photon energy range 200-450 MeV at the Mainz microtron MAMI-C, where linearly polarised photons were energy-tagged using the Glasgow-Mainz Tagged Photon Spectrometer and protons were detected in the Crystal Ball detector. The photon asymmetry Σ has been measured over a wider Eγ range than previous measurements. The strongest asymmetries were found at low missing energies where direct emission of nucleon pairs is expected. Cuts on the difference in azimuthal angles of the two ejected protons increased the magnitude of the observed asymmetries. At low missing energies the Σ data exhibit a strong angular dependence, similar to deuteron photodisintegration

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical outcome. Recently, a novel bis-anilino pyrimidine inhibitor, TAE226, was reported to efficiently inhibit FAK signaling, arrest tumor growth and invasion and prolong the life of mice with glioma or ovarian tumor implants. Here we describe the crystal structures of the FAK kinase bound to TAE226 and three related bis-anilino pyrimidine compounds. TAE226 induces a conformation of the N-terminal portion of the kinase activation loop that is only observed in FAK, but is distinct from the conformation in both the active and inactive states of the kinase. This conformation appears to require a glycine immediately N-terminal to the “DFG motif”, which adopts a helical conformation stabilized by interactions with TAE226. The presence of a glycine residue in this position contributes to the specificity of TAE226 and related compounds for FAK. Our work highlights the fact that kinases can access conformational space that is not necessarily utilized for their native catalytic regulation, and that such conformations can explain and be exploited for inhibitor specificity

Incoherent pion photoproduction on 12^{12}C

We present the first detailed measurement of incoherent photoproduction of neutral pions to a discrete state of a residual nucleus. The $^{12}$C$(\gamma,\pi^{0})^{12}$C$^{*}_{4.4MeV}$ reaction has been studied with the Glasgow photon tagger at MAMI employing a new technique which uses the large solid angle Crystal Ball detector both as a $\pi^{0}$ spectrometer and to detect decay photons from the excited residual nucleus. The technique has potential applications to a broad range of future nuclear measurements with the Crystal Ball and similar detector systems elsewhere. The data are sensitive to the propagation of the $\Delta$ in the nuclear medium and will give the first information on matter transition form factors from measurements with an electromagnetic probe. The incoherent cross sections are compared to two theoretical predictions including a $\Delta$-hole model.Comment: 4 pages, 8 figures, submitted to Physical Review Letter

Determination of the eta-transition form factor in the gamma p -< p eta -< p gamma e(+)e(-) reaction

The Dalitz decay eta -&gt; gamma e(+)e(-) has been measured using the combined Crystal Ball and TAPS photon detector setup at the electron accelerator MAMI-C. Compared to the most recent transition form-factor measurement in the e(+)e(-) channel, statistics have been improved by one order of magnitude. The e(+)e(-)invariant mass distribution shows a deviation from the QED prediction for a point-like particle, which can be described by a form-factor. Using the usual monopole transition form-factor parameterization, F(m(2)) = (1 - m(2)/Lambda(2))(-1), a value of Lambda(-2) = (1.92 +/- 0.35(stat) +/- 0.13(syst)) GeV(-2) has been determined. This value is in good agreement with a recent measurement of the eta Dalitz decay in the mu(+)mu(-) channel and with recent form-factor calculations. An improved value of the branching ratio BR(eta -&gt; gamma e(+)e(-)) = (6.6 +/- 0.4(stat) +/- 0.4(syst)) . 10(-3) has been determined. (C) 2011 Elsevier B.V. All rights reserved

Photon asymmetry measurements of γ→ p→ π0p for Eγ= 320-650 MeV

High-statistics measurements of the photon asymmetry Σ for the γ→ p→ π0p reaction have been made in the center-of-mass energy range W= 1214 - 1450 MeV. The data were measured with the MAMI A2 real photon beam and Crystal Ball/TAPS detector systems in Mainz, Germany. The results significantly improve the existing world data and are shown to be in good agreement with previous measurements, and with the MAID, SAID, and Bonn-Gatchina predictions. We have also combined the photon asymmetry results with recent cross-section measurements from Mainz to calculate the profile functions, Σˇ (= σ0Σ) , and perform a moment analysis. Comparison with calculations from the Bonn-Gatchina model shows that the precision of the data is good enough to further constrain the higher partial waves, and there is an indication of interference between the very small F-waves and the N(1520) 3 / 2 - and N(1535) 1 / 2 - resonances