Migrant workers in the East Midlands labour market 2010

This report is an update of previous intelligence (Migrant Workers in the East Midlands Labour Market 2007) on the profile and economic impact of migrant labour in the East Midlands economy

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells

Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and clinical cancer research. While antiangiogenic drugs are now incorporated into standard clinical practice, as with all cancer therapies, tumors can eventually become resistant by employing a variety of strategies to receive nutrients and oxygen in the event of therapeutic assault. Herein, we concentrate and review in detail three of the principal mechanisms of antiangiogenic therapy escape: (1) upregulation of compensatory/alternative pathways for angiogenesis; (2) vasculogenic mimicry; and (3) vessel co-option. We suggest that an understanding of how a cancer cell adapts to antiangiogenic therapy may also parallel the mechanisms employed in the bourgeoning tumor and isolated metastatic cells delivering responsible for residual disease. Finally, we speculate on strategies to adapt antiangiogenic therapy for future clinical uses.http://www.mdpi.com/1422-0067/17/9/148

High-frequency high-voltage high-power DC-to-DC converters

The current and voltage waveshapes associated with the power transitor and the power diode in an example current-or-voltage step-up (buck-boost) converter were analyzed to highlight the problems and possible tradeoffs involved in the design of high voltage high power converters operating at switching frequencies in the range of 100 Khz. Although the fast switching speeds of currently available power diodes and transistors permit converter operation at high switching frequencies, the resulting time rates of changes of current coupled with parasitic inductances in series with the semiconductor switches, produce large repetitive voltage transients across the semiconductor switches, potentially far in excess of the device voltage ratings. The need is established for semiconductor switch protection circuitry to control the peak voltages appearing across the semiconductor switches, as well as to provide the waveshaping action require for a given semiconductor device. The possible tradeoffs, as well as the factors affecting the tradeoffs that must be considered in order to maximize the efficiency of the converters are enumerated

Analysis of transistor and snubber turn-off dynamics in high-frequency high-voltage high-power converters

Dc to dc converters which operate reliably and efficiently at switching frequencies high enough to effect substantial reductions in the size and weight of converter energy storage elements are studied. A two winding current or voltage stepup (buck boost) dc-to-dc converter power stage submodule designed to operate in the 2.5-kW range, with an input voltage range of 110 to 180 V dc, and an output voltage of 250 V dc is emphasized. In order to assess the limitations of present day component and circuit technologies, a design goal switching frequency of 10 kHz was maintained. The converter design requirements represent a unique combination of high frequency, high voltage, and high power operation. The turn off dynamics of the primary circuit power switching transistor and its associated turn off snubber circuitry are investigated

Deep-space navigation applications of improved ground-based optical astrometry

Improvements in ground-based optical astrometry will eventually be required for navigation of interplanetary spacecraft when these spacecraft communicate at optical wavelengths. Although such spacecraft may be some years off, preliminary versions of the astrometric technology can also be used to obtain navigational improvements for the Galileo and Cassini missions. This article describes a technology-development and observational program to accomplish this, including a cooperative effort with U.S. Naval Observatory Flagstaff Station. For Galileo, Earth-based astrometry of Jupiter's Galilean satellites may improve their ephemeris accuracy by a factor of 3 to 6. This would reduce the requirements for onboard optical navigation pictures, so that more of the data transmission capability (currently limited by high-gain antenna deployment problems) can be used for science data. Also, observations of European Space Agency (ESA) Hipparcos stars with asteroid 243 Ida may provide significantly improved navigation accuracy for a planned August 1993 Galileo spacecraft encounter

Systems analysis for ground-based optical navigation

Deep-space telecommunications systems will eventually operate at visible or near-infrared regions to provide increased information return from interplanetary spacecraft. This would require an onboard laser transponder in place of (or in addition to) the usual microwave transponder, as well as a network of ground-based and/or space-based optical observing stations. This article examines the expected navigation systems to meet these requirements. Special emphasis is given to optical astrometric (angular) measurements of stars, solar system target bodies, and (when available) laser-bearing spacecraft, since these observations can potentially provide the locations of both spacecraft and target bodies. The role of astrometry in the navigation system and the development options for astrometric observing systems are also discussed

A dc model for power switching transistors suitable for computer-aided design and analysis

A model for bipolar junction power switching transistors whose parameters can be readily obtained by the circuit design engineer, and which can be conveniently incorporated into standard computer-based circuit analysis programs is presented. This formulation results from measurements which may be made with standard laboratory equipment. Measurement procedures, as well as a comparison between actual and computed results, are presented

Are multiphase competition & order-by-disorder the keys to understanding Yb2Ti2O7?

If magnetic frustration is most commonly known for undermining long-range order, as famously illustrated by spin liquids, the ability of matter to develop new collective mechanisms in order to fight frustration is no less fascinating, providing an avenue for the exploration and discovery of unconventional properties of matter. Here we study an ideal minimal model of such mechanisms which, incidentally, pertains to the perplexing quantum spin ice candidate Yb2Ti2O7. Specifically, we explain how thermal and quantum fluctuations, optimized by order-by-disorder selection, conspire to expand the stability region of an accidentally degenerate continuous symmetry U(1) manifold against the classical splayed ferromagnetic ground state that is displayed by the sister compound Yb2Sn2O7. The resulting competition gives rise to multiple phase transitions, in striking similitude with recent experiments on Yb2Ti2O7 [Lhotel et al., Phys. Rev. B 89 224419 (2014)]. Considering the effective Hamiltonian determined for Yb2Ti2O7, we provide, by combining a gamut of numerical techniques, compelling evidence that such multiphase competition is the long-sought missing key to understanding the intrinsic properties of this material. As a corollary, our work offers a pertinent illustration of the influence of chemical pressure in rare-earth pyrochlores.Comment: 9 page

Barro's fertility equations: the robustness of the role of female education and income

Barro and Lee (1994) and Barro and Sala-i-Martin (1995) find that real per-capita GDP and both male and female education have important effects on fertility in their cross-country empirical studies. In order to assess the robustness of their results, their estimated models are subjected to specification and diagnostic testing, the effects on the model of using the improved Barro and Lee (1996) cross-country data on educational attainment of the population aged 15 and over are examined, and the different specifications used by Barro and Lee and by Barro and Sala-i-Martin compared. The results obtained suggest that their fertility equations do not perform well in terms of diagnostic testing, and are very sensitive to the use of different vintages of the educational attainment proxies and of the Summers-Heston cross-country income data. A robust explanation of fertility, to link with empirical growth equations, has, therefore, not yet been found; further work is required in this area

The Far-Infrared/Radio Correlation in Nearby Abell Clusters

A comprehensive study of the effect of the cluster environment on the far- infrared (FIR)/radio correlation in nearby Abell clusters is presented. Using the cluster radio galaxy database from Miller & Owen (2001) and optical spectroscopy and high resolution radio images to remove AGN, we assess the FIR/radio correlation of cluster galaxies from the centers of the clusters out well past the classical Abell radius. The FIR/radio correlation is shown to hold quite well for star forming galaxies, and the FIR and radio fluxes for cluster AGN are also well correlated. In the case of AGN, the relative radio- to-FIR fluxes are greater and the scatter in the correlation is larger than those seen for star forming galaxies. We also find that there is a rare but statistically significant excess of star forming galaxies with enhanced radio emission in the centers of the clusters, and that the degree of this enhancement is typically a factor of two or three. The FIR/radio correlation for cluster star forming galaxies is also tested against line-of-sight velocity relative to the cluster systemic velocities, but no significant correlation is found. While the radial dependence of the FIR/radio correlation is consistent with the model wherein ram pressure increases the cluster galaxies' magnetic field strengths through compression, the velocity data do not confirm this model. Although a contribution from ram pressure can not be ruled out, the thermal pressure due to the ICM alone is an equally viable alternative. The high resolution radio images largely reject the hypothesis that the increased radio emission arises from an AGN component, strengthening the claim that the change in the correlation is caused by a change in the environment of the galaxies.Comment: 26 pages, including 5 figures (uses AASTeX 5.0). Accepted for publication in the Astronomical Journa