Oportunidades para desarrollar la esfera moral de la personalidad en niños con discapacidad intelectual

This article analyzes scholarly approaches to the moral development of personality, describes the views of particular authors on this issue from the historical perspective; highlights and defines specific features and structural components of this notion; conducts a comparative analysis of moral development in case of normal ontogenesis and in case of intellectual disability. It also attempts to synthesize the existing scholarly approaches to the methods and conditions for effective moral development of children with intellectual disability in correlations with the structural components. In the main section of the article, the authors provide a general overview of the correction methods facilitating moral development and summarize the results of the experimental research of moral development in children with intellectual disabilities of the early school age.Este artículo analiza los enfoques académicos del desarrollo moral de la personalidad, describe las opiniones de autores particulares sobre este tema desde la perspectiva histórica; destaca y define características específicas y componentes estructurales de esta noción; realiza un análisis comparativo del desarrollo moral en caso de ontogénesis normal y en caso de discapacidad intelectual. También intenta sintetizar los enfoques académicos existentes sobre los métodos y condiciones para el desarrollo moral efectivo de los niños con discapacidad intelectual en correlaciones con los componentes estructurales. En la sección principal del artículo, los autores proporcionan una visión general de los métodos de corrección que facilitan el desarrollo moral y resumen los resultados de la investigación experimental del desarrollo moral en niños con discapacidades intelectuales de la edad escolar temprana

Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment

<p>Abstract</p> <p>Background</p> <p>The mechanisms of immune response are structured within a highly complex regulatory system. Genetic associations with variation in the immune response to rubella vaccine have typically been assessed one locus at a time. We simultaneously assessed the associations between 726 SNPs tagging 84 candidate immune response genes and rubella-specific antibody levels. Blood samples were obtained from 714 school-aged children who had received two doses of MMR vaccine. Associations between rubella-specific antibody levels and 726 candidate tagSNPs were assessed both one SNP at a time and in a variety of multigenic analyses.</p> <p>Results</p> <p>Single-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). While there was not significant evidence in favor of epistatic genetic associations among the candidate SNPs, multigenic analyses identified 29 SNPs significantly associated with rubella antibody levels when selected as a group (p = 0.017). This collection of SNPs included not only those that were significant univariately, but others that would not have been identified if only considered in isolation from the other SNPs.</p> <p>Conclusions</p> <p>For the first time, multigenic assessment of associations between candidate SNPs and rubella antibody levels identified a broad number of genetic associations that would not have been deemed important univariately. It is important to consider approaches like those applied here in order to better understand the full genetic complexity of response to vaccination.</p

Extended LTA, TNF, LST1 and HLA Gene Haplotypes and Their Association with Rubella Vaccine-Induced Immunity

Recent studies have suggested the importance of HLA genes in determining immune responses following rubella vaccine. The telomeric class III region of the HLA complex harbors several genes, including lymphotoxin alpha (LTA), tumor necrosis factor (TNF) and leukocyte specific transcript -1 (LST1) genes, located between the class I B and class II DRB1 loci. Apart from HLA, little is known about the effect of this extended genetic region on HLA haplotypic backgrounds as applied to immune responses.We examined the association between immune responses and extended class I-class II-class III haplotypes among 714 healthy children after two doses of rubella vaccination. These extended haplotypes were then compared to the HLA-only haplotypes. The most significant association was observed between haplotypes extending across the HLA class I region, ten-SNP haplotypes, and the HLA class II region (i.e. A-C-B-LTA-TNF-LST1-DRB1-DQA1-DQB1-DPA1-DPB1) and rubella-specific antibodies (global p-value of 0.03). Associations were found between both extended A*02-C*03-B*15-AAAACGGGGC-DRB1*04-DQA1*03-DQB1*03-DPA1*01-DPB1*04 (p = 0.002) and HLA-only A*02-C*03-B*15-DRB1*04-DQA1*03-DQB1*03-DPA1*01-DPB1*04 haplotypes (p = 0.009) and higher levels of rubella antibodies. The class II HLA-only haplotype DRB1*13-DQA1*01-DQB1*06-DPA1*01-DPB1*04 (p = 0.04) lacking LTA-TNF-LST1 SNPs was associated with lower rubella antibody responses. Similarly, the class I-class II HLA-only A*01-C*07-B*08-DRB1*03-DQA1*05-DQB1*02-DPA1*01-DPB1*04 haplotype was associated with increased TNF-alpha secretion levels (p = 0.009). In contrast, the extended AAAACGGGGC-DRB1*01-DQA1*01-DQB1*05-DPA1*01-DPB1*04 (p = 0.01) haplotype was found to trend with decreased rubella-specific IL-6 secretion levels.These data suggest the importance of examining both HLA genes and genes in the class III region as part of the extended haplotypes useful in understanding genomic drivers regulating immune responses to rubella vaccine

HR part of corporate information system of Moscow power engineering institute

The article provides an overview of the developed and implemented in the MPEI HR-system, its features, used technologiesВ статье проводится обзор разработанной и внедренной в НИУ МЭИ системы кадрового учета, её особенностей, использованных технологи

FEATURES OF STEROID REGULATION OF CONGENITAL PROTECTIVE FACTORS AND OSTEOTROPIC MEDIATORS OF ORAL FLUID IN PREGNANT WOMEN WITH INFLAMMATORY PERIODONTAL DISEASES

Aim. To study changes in antimicrobial and osteotropic oral fluid mediators during pregnancy in women with chronic generalized periodontitis (CGР) of mild and moderate severity, taking into account the factor of steroid regulation by cortisol.Materials and methods. Among the 62 pregnant women (age 18 to 35 years), depending on the presence or absence of inflammatory periodontal diseases, the main group (n=31) with moderate and moderate CGР and control group (n=31) with no disease were formed. In addition, 32 healthy non-pregnant women (age 18 to 30 years) examined the oral fluid in the same diagnostic volume. In the oral liquid, the amount of catelicidin LL-37, osteoprotegerin and cortisol was determined using a solid-phase immunoassay method. Laboratory studies were conducted in I (8-12 weeks), II (13-27 weeks) and III (28-40 weeks) trimester of pregnancy.Results. In pregnant women with a physiologically pregnant pregnancy and in the absence of dental diseases in the oral fluid with a consequent increase in the concentration of cortisol, there was a decrease in the content of catelicidin LL-37 1 trimester followed by an increase in the 2nd and 3rd trimesters of the antimicrobial potential of the oral biological environment, an increase in the concentration of osteoprotegerin that inhibits the activity of osteoresorption in the alveolar bone. In pregnant women with CGR of mild and moderate severity, a marked increase in the concentration of cortisol in the oral fluid was accompanied in the first two terms by an increased content of cathelicidin LL-37 and activation of antimicrobial congenital mechanisms of resistance to pathogenic bacteria, followed by a decrease in the antimicrobial factor to the third trimester of the gestation period, a consistent decrease in the content of osteoprotegerin in mixed saliva.Conclusion. The presence of CGР of mild and moderate severity in pregnant women leads to a dissociation of the connection between cortisol mixed saliva and immune defense factors, osteotropic mediators in contrast to women who do not suffer from dental pathology during the gestational period

Psychophysiological adaptation of students to information training in high school

The health status of young people depends on the adaptation reserves. Assessment of students’ adaptation to the teaching load is one of the most important tasks of age physiology. The results showed that students adapt to the educational process for the academic year passed with a functional voltage cardio-vascular system and a small decrease in health.Состояние здоровья молодых людей зависит от резервов адаптации. Оценка адаптации учащихся к учебным нагрузкам является одной из важнейших задач возрастной физиологии. Результаты исследования показали, что у студентов адаптация к учебному процессу за год обучения прошла с функциональным напряжением сердечно-сосудистой системы и небольшим снижением здоровья

Оптимизация формы сигналов с квадратурной амплитудной модуляцией с использованием критерия заданной скорости спада уровня внеполосных излучений

Introduction. The growth in the volume of information transmitted through communication channels leads to their significant congestion. Almost all methods conventionally used to increase the data transfer rate in given frequency bands have been exhausted. In this regard, it is of interest to use new approaches aimed at improving the spectral efficiency of radio engineering and telecommunication systems by applying optimal signals that make it possible to use the bandwidth reserves of transmission channels given by Shannon's theory.Aim. Improvement of the spectral efficiency of digital messaging systems by using signals with a compact spectrum and increased volume of the channel alphabet at the same time as minimizing energy losses.Materials and methods. When searching for optimal signals, the mathematical apparatus of communication theory and functional analysis, as well as the methods of calculus of variations, were used. The evaluation of bit error rate performance of the obtained optimal signals transmitted in a channel with additive white Gaussian noise was performed in the MatLab environment. Results. It was established that, in a channel with additive white Gaussian noise, optimal signals with a signal constellation size of 64 in the case of quadrature amplitude-phase modulation provide an energy gain of more than 1 dB relative to signals obtained by narrowband filtering under the conditions of uncontrolled intersymbol interference. Optimal signals were shown to provide for an energy gain of 4.9 dB with respect to signals based on narrow-band filtering at a fixed spectral efficiency of 7 (bit/s)/Hz.Conclusion. The paper proposes a method for improving the spectral efficiency of quadrature signals with amplitudephase modulation, based on the use of optimal pulse shapes obtained as a result of solving an optimization problem. The optimization problem was solved according to the criterion of minimizing out-of-band emissions with the constraint on bit error rate performance in case of amplitude-phase modulation. The energy and spectral efficiency of signals with optimal pulse shapes and signals based on narrow-band filtering were compared.Введение. Рост объемов передаваемой информации по каналам связи приводит к их существенной перегруженности. Практически все используемые традиционные методы повышения скорости передачи данных в заданных полосах частот исчерпаны. В этой связи представляет интерес использование новых подходов, направленных на повышение спектральной эффективности радиотехнических и телекоммуникационных систем путем применения оптимальных сигналов, позволяющих задействовать резервы пропускной способности каналов передачи, которые дает теория Шеннона.Цель работы. Повышение спектральной эффективности систем передачи цифровых сообщений путем применения сигналов с компактным спектром и увеличения объема канального алфавита при минимизации энергетических потерь.Материалы и методы. При поиске оптимальных сигналов используется математический аппарат теории связи и функционального анализа, а также методы вариационного исчисления. Оценка помехоустойчивости приема полученных оптимальных сигналов при передаче в канале с аддитивным белым гауссовским шумом выполнена в среде MatLab.Результаты. Установлено, что в канале с аддитивным белым гауссовским шумом оптимальные сигналы при размере сигнального созвездия 64 в случае квадратурной амплитудно-фазовой модуляции обеспечивают энергетический выигрыш более 1 дБ относительно сигналов, которые получаются путем узкополосной фильтрации в условиях неконтролируемой межсимвольной интерференции. Показано, что оптимальные сигналы позволяют получить энергетический выигрыш 4.9 дБ по отношению к сигналам, построенным на основе узкополосной фильтрации, при фиксированной спектральной эффективности 7 (бит/с)/Гц.Заключение. Предложен метод повышения спектральной эффективности квадратурных сигналов с амплитудно-фазовой модуляцией, основанный на применении оптимальных форм импульсов, полученных в ходе решения оптимизационной задачи. Приведена процедура решения оптимизационной задачи по критерию минимизации внеполосных излучений при наличии ограничения на помехоустойчивость приема в случае амплитудно-фазовой модуляции. Выполнено сравнение энергетической и спектральной эффективности, обеспечиваемой сигналами с оптимальными формами импульсов и сигналами, построенными на основе узкополосной фильтрации

Application of an Oil-Displacing Composition for Increasing Flow Rate of Low Producing High-Viscosity Oil Wells of the Usinskoye Oil Field

The results of a pilot application of a chemical composition for enhanced oil recovery developed at the IPC SB RAS are presented. The EOR-composition was tested in 2014 at the Permian-Carboniferous heavy oil deposit at the Usinskoye oil field. It is very effective for an increase in oil production rate and decrease in water cuttings of well production. In terms of the additionally produced oil, the resulting effect is up to 800 tons per well and its duration is up to 6 months. The application of technologies of low-productivity-well stimulation using the oil-displacing IKhNPRO system with controlled viscosity and alkalinity is thought to be promising. This composition is proposed for the ‘cold’ stimulation of high-viscosity oil production as an alternative to thermal methods

The LBNO long-baseline oscillation sensitivities with two conventional neutrino beams at different baselines

The proposed Long Baseline Neutrino Observatory (LBNO) initially consists of $\sim 20$ kton liquid double phase TPC complemented by a magnetised iron calorimeter, to be installed at the Pyh\"asalmi mine, at a distance of 2300 km from CERN. The conventional neutrino beam is produced by 400 GeV protons accelerated at the SPS accelerator delivering 700 kW of power. The long baseline provides a unique opportunity to study neutrino flavour oscillations over their 1st and 2nd oscillation maxima exploring the $L/E$ behaviour, and distinguishing effects arising from $\delta_{CP}$ and matter. In this paper we show how this comprehensive physics case can be further enhanced and complemented if a neutrino beam produced at the Protvino IHEP accelerator complex, at a distance of 1160 km, and with modest power of 450 kW is aimed towards the same far detectors. We show that the coupling of two independent sub-MW conventional neutrino and antineutrino beams at different baselines from CERN and Protvino will allow to measure CP violation in the leptonic sector at a confidence level of at least $3\sigma$ for 50\% of the true values of $\delta_{CP}$ with a 20 kton detector. With a far detector of 70 kton, the combination allows a $3\sigma$ sensitivity for 75\% of the true values of $\delta_{CP}$ after 10 years of running. Running two independent neutrino beams, each at a power below 1 MW, is more within today's state of the art than the long-term operation of a new single high-energy multi-MW facility, which has several technical challenges and will likely require a learning curve.Comment: 21 pages, 12 figure