Sobre la expresión de anticuerpos anti-SSA-RO/SSB-LA y su correlación clínica y serológica dentro de las enfermedades sistémicas autoinmunes

El sistema de autoanticuerpos anti-Ro y anti-La es uno de los más útiles en la práctica clínica diaria y también de los más ampliamente estudiados debido a su alta prevalencia en la población de pacientes con ERAS. A lo largo de los años se ha descrito una gran variedad asociaciones clínicas, no siempre coincidentes. No hay prácticamente estudios que incluyan todo el espectro de las ERAS, incluyendo las variantes juveniles, y en una población homogénea étnica y geográficamente. Las evidencias actuales indican que las proteínas Ro60 kDa y Ro 52 kDa no son parte de un complejo macromolecular estable y potencialmente esto se traduce en que los AAC anti-Ro 60 kDa y anti-Ro 52 kDa condicionan asociaciones clínicas diferentes. OBJETIVO: Determinar si existen patrones clínicos relacionados con la detección de AAC anti-Ro 60 kDa, anti-Ro 52 kDa y anti-La en pacientes con ERAS, independientemente del diagnóstico..

Use and management of ict for learning in the degrees of humanities, of the Pontifical Catholic University Mother and Teacher

El uso y manejo de las TIC en el aprendizaje es fundamental para brindar una formación exitosa a los estudiantes universitarios. Para ello se hace necesario la adquisición y desarrollo de las competencias digitales docentes, las cuales se fortalecen por medio de la preparación académica y la motivación positiva para brindar formación sólida a los estudiantes y futura generación. El presente estudio nace de la inquietud de la Pontificia Universidad Católica Madre y Maestra (PUCMM_CSD) por avanzar en este aspecto, estableciendo como objetivos principales de investigación precisar los dispositivos y herramientas digitales que posee la PUCMM_CSD en la titulaciones de humanidades para el proceso de enseñanza-aprendizaje; describir las competencias digitales que posee el profesorado de la PUCMM_CSD de estas titulaciones; conocer la percepción de los estudiantes de las titulaciones de humanidades, sobre la eficacia en su formación de los enfoques educativos implementados por los docentes mediados por las TIC, con la finalidad de proponer un plan de formación para la mejora de la práctica docente mediada por las TIC en la PUCMM_CSD. El estudio responde a diseño no experimental, de corte descriptico ex post facto, para el cual se adaptaron los cuestionarios de (Agrada, Hinojo y Sola 2016) y agregaron los ítems necesarios según las teorías analizadas, y para recabar información del alumnado se utilizó una adaptación del cuestionario Mengual, Roig y Blasco (2011). La población objeto de estudio fue de 92 profesores de los cuales se seleccionó una muestra de 80 de la PUCMM_CDS de Santo Domingo, República Dominicana y la muestra de estudiantes, que formó parte del grupo informante, fue de 1.137 estudiantes de la Facultad de Humanidades. Los datos obtenidos se procesaron en el programa estadístico Statictical Packge for the Social Sciences (SPSS) y, en función de los objetivos y las preguntas de investigación que vertebraron el estudio, se les aplicó un análisis descriptivo e inferencial. Es necesario fortalecer las competencias digitales del docente de la PUCMM_CSD por medio de un Plan de formación que nace de los resultados y conclusiones que se han obtenido, sobre todo hay que hacer un acercamiento a los recursos tecnológicos de la mano de las tecnologías emergentes, las aplicaciones en línea que facilitan la elaboración de materiales en línea y en entornos cooperativos, la inclusión de las Redes Sociales en el entorno educativo, lo relacionado con los gestores bibliográficos y la utilización de las funciones del aula virtual propia de la PUCMM.The use and management of ICT in learning is fundamental to providing successful training for university students. To this end, it is necessary to acquire and develop the digital teaching competencies, which are strengthened through academic preparation and positive motivation to provide solid training for students and future generation. The present study is born of the concern of the Pontifical Mother and Teacher Catholic University (PUCMM_CSD) to advance in this aspect, establishing as main objectives of research to specify the digital devices and tools that PUCSD possesses in the degrees of humanities for the teaching-learning process; Describe the digital skills that the PUCM_CSD faculty hold for these degrees; To know the students' perception of the humanities degrees, about the effectiveness in their formation of the educational approaches implemented by teachers mediated by ICT, With the aim of proposing a training plan for the improvement of ICT-mediated teaching practice in the PUCMM_CSD. The study responds to a non-experimental design, descriptive ex post facto, for which the questionnaires of (Agrega, Hinojo & Sola 2016) were adapted and the necessary items added according to the theories analyzed, and an adaptation of the questionnaire Mengal, Roig & Blasco (2011) was used to obtain information from the students. The study population was 92 teachers, from whom a sample of 80 was selected from the PUCMM CDS of Santo Domingo, Dominican Republic, and the sample of students, which was part of the reporting group, was 1,137 students from the Faculty of Humanities. The data obtained were processed in the statistical program Statistical Packge for the Social Sciences (SPSS) and, depending on the objectives and research questions that vertebrate the study, a descriptive and inferential analysis was applied. It is necessary to strengthen the digital skills of the PUCMM_CSD teacher through a Training Plan that arises from the results and conclusions that have been obtained, above all it is necessary to make an approach to technological resources with the hand of emerging technologies, online applications that facilitate the production of materials online and in cooperative environments, the inclusion of Social Networks in the educational environment, what is related to bibliographic managers and the use of the functions of the PUCMM's own virtual classroom

Hormonal dependence and cancer in Systemic Lupus Erythematosus

Objective: To estimate the incidence and analyze any cancer-associated factors in patients with systemic lupus erythematosus (SLE), differentiating between hormone-sensitive (HS) and non-HS cancers. Methods: This was a retrospective multicenter study of a patient cohort from the Systemic Lupus Erythematosus Registry of the Spanish Society of Rheumatology. Included were the first cancer post-SLE diagnosis, clinical and sociodemographic information, cumulative damage, severity, comorbidities, treatments, and refractoriness. Cancers were classified as HS (prostate, breast, endometrium, and ovarian) and non-HS (the remainder). The standardized incidence ratio (SIR) was calculated and logistic regression models were built. Results: A total of 3,539 patients (90.4% women) were included, 154 of whom had cancer (91% female), and 44 had HS cancer (100% female). The cancer SIR was 1.37 (95% confidence interval [95% CI] 1.15-1.59), with higher values in women age <65 years (SIR 2.38 [95% CI 1.84-2.91]). The SIR in women with HS versus non-HS cancer was 1.02 (95% CI 0.13-1.91) and 1.93 (95% CI 0.98-2.89). In HS versus non-HS cancers, SLE diagnostic age (odds ratio [OR] 1.04 [P = 0.002] versus 1.04 [P = 0.019]), and period of disease evolution (OR 1.01 [P < 0.001] versus 1.00 [P = 0.029]) were associated with cancer. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (OR 1.27 [P = 0.022]) and angiotensin-converting enzyme (ACE) inhibitor prescriptions (OR 2.87 [P = 0.048]) were associated with non-HS cancers. Conclusion: Cancer incidence in patients with SLE was higher than in the Spanish population, particularly among young women. This increase might be due to non-HS cancers, which would be associated with SLE involving greater cumulative damage where more ACE inhibitors are prescribed.The RELESSER Registry was partially funded by GSK, Roche, UCB, Lilly and Novartis. The sponsors had no role in the study design, data collection, analysis or interpretation, in writing the report, or in the decision to submit the article for publication. Dr. Pego-Reigosa is supported by grant 316265 (BIOCAPS) from the European Union 7th Framework Program (FP7/REGPOT-2012- 2013.1). The FIS Grant PI11/02857 (Instituto Carlos III, Fondos FEDER) supported this study

Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER).

Objective: To assess the incidence of serious infection (SI) and associated factors in a large juvenile-onset systemic lupus erythematosus (jSLE) retrospective cohort. Methods: All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet =4 ACR-97 SLE criteria and disease onset <18 years old (jSLE), were retrospectively investigated for SI (defined as either the need for hospitalization with antibacterial therapy for a potentially fatal infection or death caused by the infection). Standardized SI rate was calculated per 100 patient years. Patients with and without SI were compared. Bivariate and multivariate logistic and Cox regression models were built to calculate associated factors to SI and relative risks. Results: A total of 353 jSLE patients were included: 88.7% female, 14.3 years (± 2.9) of age at diagnosis, 16.0 years (± 9.3) of disease duration and 31.5 years (±10.5) at end of follow-up. A total of 104 (29.5%) patients suffered 205 SI (1, 55.8%; 2-5, 38.4%; and =6, 5.8%). Incidence rate was 3.7 (95%CI: 3.2–4.2) SI per 100 patient years. Respiratory location and bacterial infections were the most frequent. Higher number of SLE classification criteria, SLICC/ACR DI score and immunosuppressants use were associated to the presence of SI. Associated factors to shorter time to first infection were higher number of SLE criteria, splenectomy and immunosuppressants use. Conclusions: The risk of SI in jSLE patients is significant and higher than aSLE. It is associated to higher number of SLE criteria, damage accrual, some immunosuppressants and splenectomy

Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. METHODS: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil =4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. RESULTS: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. CONCLUSION: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage. © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology

Caracterización de la investigación, el desarrollo tecnológico y la innovación en el sector productivo de la región fronteriza colombo venezolana

En el libro se presenta la recopilación de proyectos de Investigación e Innovación tecnológica como resultado del desarrollo de actividades investigativas, donde se involucran grupos de investigación y semilleros, instructores investigadores, docentes universitarios, administrativos, aprendices, estudiantes universitarios y empresarios del ámbito regional, nacional e internacional, quienes motivados por su espíritu emprendedor e innovador le apostaron a involucrarse en proyectos desde las áreas de automatización, electrónica y telecomunicaciones, gestión de hábitat , Diseño e implementación de soluciones en TIC, Gestión del negocio emprendimiento y empresarismo, innovación educativa y diseño de vestuario.The book presents the compilation of Research and Technological Innovation projects as a result of the development of research activities, where research groups and seedbeds, research instructors, university teachers, administrative staff, apprentices, university students and entrepreneurs from the regional, national level are involved. and international, who, motivated by his entrepreneurial and innovative spirit, bet him to get involved in projects from the areas of automation, electronics and telecommunications, habitat management, Design and implementation of ICT solutions, Business management, entrepreneurship and entrepreneurship, educational innovation and design. wardrobe.Caracterización de la investigación, el desarrollo tecnológico y la innovación en el sector productivo de la región fronteriza colombo venezolana -- Modelo de un sistema hidráulico controlado por redes neuronales – Sistema de gestión y monitoreo de consumo de servicios domiciliarios fomentando la “sostenibilidad inductiva” -- Cálculo de los parámetros hidráulicos y mecánicos de un prototipo robótico para la fumigación de cultivos de media y baja altura -- Manipulador robótico en el sistema integrado por computadora plataforma Cim-C -- Planificación multinivel y conflictos generados por la transformación de los espacios agrarios en el sector periurbano fronterizo de los trapiches, villa del rosario. -- Herramienta tecnológica para la vinculación del aprendiz sena del programa de articulación media con el sector productivo de la ciudad de bucaramanga -- Global kids máquina de intercambio financiero Global Kids financial Exchange machine – Desarrollo de aplicación móvil para la enseñanza e instrucción del área de documentación y gestión administrativa -- Diseño de una aplicación informática on-line para optimizar la gestión de los procesos, tramites e informes de los materiales de formación del sena centro cies regional norte de santander -- creación sala hub de consultoría estratégica mipymes norte de santander -- Diseño recorrido virtual de gestión documental Regional Norte de Santander: SENA -- Factores de riesgo provocadas por el incremento de estrés en las empresas industriales mexicanas -- Logística de la comercialización del plátano procedente de los municipios buenavista, córdoba y pijao -- Sistema de información móvil integrador de procesos formativos del sena con la comunidad educativa -- Sistematización de la información contable y financiera de los proyectos de aula en la media técnica -- BANKIDS juego didáctico y financiero -- Causas que originan la mala ortografía en los aprendices de la red de gestión administrativa y servicios financieros -- Informe sobre la deserción de aprendices de gestión administrativa y servicios financieros -- uso de las ntic desde el semillero de investigación e innovación virtual e-innovacmm centro metalmecánicona207 página

XVI International Congress of Control Electronics and Telecommunications: "Techno-scientific considerations for a post-pandemic world intensive in knowledge, innovation and sustainable local development"

Este título, sugestivo por los impactos durante la situación de la Covid 19 en el mundo, y que en Colombia lastimosamente han sido muy críticos, permiten asumir la obligada superación de tensiones sociales, políticas, y económicas; pero sobre todo científicas y tecnológicas. Inicialmente, esto supone la existencia de una capacidad de la sociedad colombiana por recuperar su estado inicial después de que haya cesado la perturbación a la que fue sometida por la catastrófica pandemia, y superar ese anterior estado de cosas ya que se encontraban -y aún se encuentran- muchos problemas locales mal resueltos, medianamente resueltos, y muchos sin resolver: es decir, habrá que rediseñar y fortalecer una probada resiliencia social existente - producto del prolongado conflicto social colombiano superado parcialmente por un proceso de paz exitoso - desde la tecnociencia local; como lo indicaba Markus Brunnermeier - economista alemán y catedrático de economía de la Universidad de Princeton- en su libro The Resilient Society…La cuestión no es preveerlo todo sino poder reaccionar…aprender a recuperarse rápido.This title, suggestive of the impacts during the Covid 19 situation in the world, and which have unfortunately been very critical in Colombia, allows us to assume the obligatory overcoming of social, political, and economic tensions; but above all scientific and technological. Initially, this supposes the existence of a capacity of Colombian society to recover its initial state after the disturbance to which it was subjected by the catastrophic pandemic has ceased, and to overcome that previous state of affairs since it was found -and still is find - many local problems poorly resolved, moderately resolved, and many unresolved: that is, an existing social resilience test will have to be redesigned and strengthened - product of the prolonged Colombian social conflict partially overcome by a successful peace process - from local technoscience; As Markus Brunnermeier - German economist and professor of economics at Princeton University - indicates in his book The Resilient Society...The question is not to foresee everything but to be able to react...learn to recover quickly.Bogot

Atitudes dos professores face à utilização e manejo das TIC na formação eficiente

The teacher’s attitude in the use and management of ICT is essential to provide successful training to their students; it must be strengthened through academic preparation and positive motivation to provide a solid education to students and the future generation. The main objective of this article is to describe the attitude of teachers in the use and management of ICTs, the design of the study is non-experimental, descriptive ex post facto, we adapted the Agrada, Hinojo and Sola questionnaires to which we added the necessary items according to the theory analyzed. The population is ninety-two professors, of which we apply the questionnaire to a sample of eighty professors from the Faculty of Humanities of the Pontificia Universidad Católica Madre y Maestra de Santo Domingo, Dominican Republic. The information obtained was processed in the statistical program Statistical Package for the Social Sciences (SPSS), then we proceeded to extract the information for analysis and discussion. Finally, we present the conclusions of interest that show the fundamental attitudes in university teachers to ensure that their students acquire educational knowledge that allows them to be successful in learning processes and be successful professionals in society.La actitud del docente en el uso y manejo de las tecnologías de la información y las comunicaciones (TIC) es fundamental para brindar una formación exitosa en sus estudiantes; la misma debe fortalecerse por medio de una preparación académica y una motivación positiva que brinde una formación sólida a los estudiantes y a las futuras generaciones. El objetivo principal de este artículo es “describir la actitud de los docentes en el uso y manejo de las TIC”. Para alcanzar este objetivo optamos por una investigación no experimental,de corte descriptico ex post facto, y adaptamos los cuestionarios de Agrada, Hinojo y Sola (2016), a los cuales incorporamos los ítems necesarios según la teoría analizada. La población es de noventa y dos profesores, de los cuales aplicamos el cuestionario a una muestra de ochenta docentes de la Facultad de Humanidades de la Pontificia Universidad Católica Madre y Maestra (PUCMM) (Santo Domingo, República Dominicana). La información obtenida fue procesada en el programa estadístico Statictical Packge for the Social Sciences (SPSS); luego procedimos a extraer la información para su análisis y discusión; finalmente presentamos las conclusiones de interés, las cuales muestran las actitudes fundamentales en los docentes universitarios para lograr que sus estudiantes adquieran conocimientoseducativos que les permita ser exitosos en los procesos de aprendizaje y ser profesionales exitosos en la sociedad.A atitude do professor no uso e manejo das tecnologias da informação e comunicações é de fundamental importância para oferecer uma formação bem-sucedida aos seus alunos; esta deve ser fortalecida por meio de uma preparação académica e uma motivação positiva que proporcione uma formação sólida aos estudantes e as futuras gerações. O objetivo principal desse artigo é “descobrir a atitude dos docentes face a utilização e o manejo das TIC”. Para alcançar o objetivo optamos por estudo não experimental, descritivo ex post facto, e nos adaptamos os questionários de Agrada, Hinojo e Sola (2016), aos quais incorporamos os itens necessários de acordo com a teoria analisada. O total de professores é de noventa e dois, dos quais o questionário foi aplicado a oitenta profissionais docentes da Faculdade de Ciências Humanas da Pontifícia Universidade Católica Madre e Mestra (PUCMM) (Santo Domingo, República Dominicana). A informação obtida foi processada no programa estadístico Statictical Packge for the Social Sciences (SPSS); depois prosseguimos a tirar a informação para a sua análise e discussão; finalmente apresentamos as conclusões, as quais mostram as atitudes fundamentais nos professores universitários para conseguir que seus estudantes adquiram conhecimentos educativos que lhes permita ser bem sucedidos nos processos de aprendizagem e ser profissionais bem reconhecidos na sociedade

MODELAJE DE LA VARIABILIDAD ESPACIAL EN DELINEACIONES DE MAPAS DE SUELO USANDO SISTEMAS DE INFORMACIÓN GEOGRÁFICA

Los mapas de suelo suponen que las unidades cartogr&aacute;ficas son internamente homog&eacute;neas. Sin embargo, existe una variabilidad interna en la unidades de mapeo, que se constituye en una de las principales limitaciones para hacer predicciones acerca de la potencialidad del suelo. El objetivo de este estudio fue modelar la variabilidad espacial del % de arcilla y del pH en el horizonte A de dos delineaciones de la unidad A3 del mapa de suelos del Sector R&iacute;o Orituco-Chaguaramas, localizado en el Estado Gu&aacute;rico, Venezuela. Las delineaciones fueron denominadas A3-1 (144 ha) y A3-2 (339 ha). Las propiedades de suelo (% de arcilla y pH) fueron analizadas para establecer las zonas con texturas medias (arcilla entre 18 y 35%) y pH neutro (pH entre 6.1 y 7.3) dentro de cada una de las delineaciones estudiadas. Adicionalmente, el &aacute;rea de suelos que cumpl&iacute;a con esta condici&oacute;n fue representada en un mapa y calculada mediante un Sistema de Informaci&oacute;n Geogr&aacute;fica. En los mapas resultantes de la superposici&oacute;n de la informaci&oacute;n de % de arcilla y pH, se apreci&oacute; como para la delineaci&oacute;n A3-1, el 62% (89.5 ha) presentaron suelos de texturas medias y pH neutro; mientras que para la delineaci&oacute;n A3-2, solo 85 ha (25%) cumplieron con esa condici&oacute;n en sus suelos superficiales, de un total de la delineaci&oacute;n de 339 ha. A pesar de que las zonas muestreadas son delineaciones de una misma unidad cartogr&aacute;fica, las proporciones de suelos superficiales con texturas medias y pH neutro son distintas, esto enfatiza la necesidad de conocer la variaci&oacute;n interna de atributos de suelo dentro de las delineaciones, sobre todo en el horizonte superficial.Palabras Claves: Variabilidad espacial de suelos, sistemas de informaci&oacute;n geogr&aacute;fica, modelaje espacial, ma&iacute;z, Gu&aacute;rico.&nbsp;Abstract&nbsp;Soil map units are supposed to be internally homogeneous. However, there is a within mapping unit variability that remains as one of the main constraints to reliable soil interpretation, and it is a limiting factor for making accurate predictions of soil performance at any particular position on the landscape. The objective of this study was to model the spatial variability of clay percentage and pH from the A horizon, in two delineations of the unit A3 from the soil map of Rio Orituco-Chaguaramas sector, located in Gu&aacute;rico State - Venezuela. The delineations were denominated A3-1 (144 ha) and A3-2 (339 ha). Soil properties (clay % and pH) were analyzed to establish areas with medium textures (clay between 18 and 35 percent) and a neutral pH (pH between 6.1 and 7.3). Additionally, the soil area that fulfilled this condition was represented in a map and calculated by means of a Geographical Information System. Thereby, the delineation A3-1 (144 ha), had 62% (89.5 ha) of medium textures and a neutral pH soils. The delineation A3-2 (339 ha), had 85 ha (25%) of superficial soils that fulfilled this condition. Although the sampling areas were delineations of the same mapping unit (A3), the proportions of superficial soils with medium textures and a neutral pH were different. This emphasizes the necessity to know the internal variation of soil attributes inside the delineations, especially in the superficial horizon.Key Words: Soil spatial variability, geographical information systems, spatial modeling, corn, Gu&aacute;rico